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Pleiotropic effects of SCZ-associated genes (Mäki-Marttunen et al. 2017)
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Python and MATLAB scripts for studying the dual effects of SCZ-related genes on layer 5 pyramidal cell firing and sinoatrial node cell pacemaking properties. The study is based on two L5PC models (Hay et al. 2011, Almog & Korngreen 2014) and SANC models (Kharche et al. 2011, Severi et al. 2012).
Mäki-Marttunen T, Lines GT, Edwards AG, Tveito A, Dale AM, Einevoll GT, Andreassen OA (2017) Pleiotropic effects of schizophrenia-associated genetic variants in neuron firing and cardiac pacemaking revealed by computational modeling.
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Neuron or other electrically excitable cell;
Neocortex L5/6 pyramidal GLU cell;
Cardiac atrial cell;
I L high threshold;
I T low threshold;
I A, slow;
Maki-Marttunen, Tuomo [tuomo.maki-marttunen at tut.fi];
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Neocortex L5/6 pyramidal GLU cell
I L high threshold
I T low threshold
I A, slow
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