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Pleiotropic effects of SCZ-associated genes (Mäki-Marttunen et al. 2017)
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Model File
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Accession:
187615
Python and MATLAB scripts for studying the dual effects of SCZ-related genes on layer 5 pyramidal cell firing and sinoatrial node cell pacemaking properties. The study is based on two L5PC models (Hay et al. 2011, Almog & Korngreen 2014) and SANC models (Kharche et al. 2011, Severi et al. 2012).
Reference:
1 .
Mäki-Marttunen T, Lines GT, Edwards AG, Tveito A, Dale AM, Einevoll GT, Andreassen OA (2017) Pleiotropic effects of schizophrenia-associated genetic variants in neuron firing and cardiac pacemaking revealed by computational modeling.
Transl Psychiatry
7
:5
[
PubMed
]
Citations
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Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Neocortex L5/6 pyramidal GLU cell;
Cardiac atrial cell;
Channel(s):
I Na,p;
I Na,t;
I L high threshold;
I T low threshold;
I A;
I K;
I M;
I h;
I K,Ca;
I Sodium;
I Calcium;
I Potassium;
I A, slow;
Na/Ca exchanger;
I_SERCA;
Na/K pump;
Kir;
Gap Junctions:
Receptor(s):
Gene(s):
Nav1.1 SCN1A;
Cav3.3 CACNA1I;
Cav1.3 CACNA1D;
Cav1.2 CACNA1C;
Transmitter(s):
Simulation Environment:
NEURON;
MATLAB;
Python;
Model Concept(s):
Schizophrenia;
Implementer(s):
Maki-Marttunen, Tuomo [tuomomm at uio.no];
Search NeuronDB
for information about:
Neocortex L5/6 pyramidal GLU cell
;
I Na,p
;
I Na,t
;
I L high threshold
;
I T low threshold
;
I A
;
I K
;
I M
;
I h
;
I K,Ca
;
I Sodium
;
I Calcium
;
I Potassium
;
I A, slow
;
Na/Ca exchanger
;
I_SERCA
;
Na/K pump
;
Kir
;
Download the displayed file
/
pleiotropy
almog
cells
BK.mod
*
Other models using BK.mod:
Layer V pyramidal cell functions and schizophrenia genetics (Mäki-Marttunen et al 2019)
ca_h.mod
ca_r.mod
cad.mod
*
Other models using cad.mod:
Layer V pyramidal cell functions and schizophrenia genetics (Mäki-Marttunen et al 2019)
epsp.mod
*
Other models using epsp.mod:
Ionic mechanisms of dendritic spikes (Almog and Korngreen 2014)
Layer V pyramidal cell functions and schizophrenia genetics (Mäki-Marttunen et al 2019)
ih.mod
*
Other models using ih.mod:
Layer V pyramidal cell functions and schizophrenia genetics (Mäki-Marttunen et al 2019)
kfast.mod
kslow.mod
na.mod
SK.mod
*
Other models using SK.mod:
Layer V pyramidal cell functions and schizophrenia genetics (Mäki-Marttunen et al 2019)
best.params
*
Other models using best.params:
Ionic mechanisms of dendritic spikes (Almog and Korngreen 2014)
Layer V pyramidal cell functions and schizophrenia genetics (Mäki-Marttunen et al 2019)
calcifcurves.py
calcsteadystate.py
cc_run.hoc
*
Other models using cc_run.hoc:
Ionic mechanisms of dendritic spikes (Almog and Korngreen 2014)
Layer V pyramidal cell functions and schizophrenia genetics (Mäki-Marttunen et al 2019)
collectfig1.py
collectfig2.py
fig1_curves.mat
fig2_curves.mat
findDCshortthreshold.py
main.hoc
*
Other models using main.hoc:
Ionic mechanisms of dendritic spikes (Almog and Korngreen 2014)
Layer V pyramidal cell functions and schizophrenia genetics (Mäki-Marttunen et al 2019)
model.hoc
*
Other models using model.hoc:
Layer V pyramidal cell functions and schizophrenia genetics (Mäki-Marttunen et al 2019)
mosinit.hoc
*
Other models using mosinit.hoc:
Ionic mechanisms of dendritic spikes (Almog and Korngreen 2014)
Layer V pyramidal cell functions and schizophrenia genetics (Mäki-Marttunen et al 2019)
mutation_stuff.py
myrun.hoc
*
Other models using myrun.hoc:
Layer V pyramidal cell functions and schizophrenia genetics (Mäki-Marttunen et al 2019)
mytools.py
*
Other models using mytools.py:
Pleiotropic effects of SCZ-associated genes (Mäki-Marttunen et al. 2017)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
params.hoc
*
Other models using params.hoc:
Ionic mechanisms of dendritic spikes (Almog and Korngreen 2014)
Layer V pyramidal cell functions and schizophrenia genetics (Mäki-Marttunen et al 2019)
runme.sh
*
Other models using runme.sh:
Pleiotropic effects of SCZ-associated genes (Mäki-Marttunen et al. 2017)
scalings.sav
load_file("nrngui.hoc") load_file("cc_run.hoc")
