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Pleiotropic effects of SCZ-associated genes (Mäki-Marttunen et al. 2017)
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Model File
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Accession:
187615
Python and MATLAB scripts for studying the dual effects of SCZ-related genes on layer 5 pyramidal cell firing and sinoatrial node cell pacemaking properties. The study is based on two L5PC models (Hay et al. 2011, Almog & Korngreen 2014) and SANC models (Kharche et al. 2011, Severi et al. 2012).
Reference:
1 .
Mäki-Marttunen T, Lines GT, Edwards AG, Tveito A, Dale AM, Einevoll GT, Andreassen OA (2017) Pleiotropic effects of schizophrenia-associated genetic variants in neuron firing and cardiac pacemaking revealed by computational modeling.
Transl Psychiatry
7
:5
[
PubMed
]
Citations
Citation Browser
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Neocortex L5/6 pyramidal GLU cell;
Cardiac atrial cell;
Channel(s):
I Na,p;
I Na,t;
I L high threshold;
I T low threshold;
I A;
I K;
I M;
I h;
I K,Ca;
I Sodium;
I Calcium;
I Potassium;
I A, slow;
Na/Ca exchanger;
I_SERCA;
Na/K pump;
Kir;
Gap Junctions:
Receptor(s):
Gene(s):
Nav1.1 SCN1A;
Cav3.3 CACNA1I;
Cav1.3 CACNA1D;
Cav1.2 CACNA1C;
Transmitter(s):
Simulation Environment:
NEURON;
MATLAB;
Python;
Model Concept(s):
Schizophrenia;
Implementer(s):
Maki-Marttunen, Tuomo [tuomomm at uio.no];
Search NeuronDB
for information about:
Neocortex L5/6 pyramidal GLU cell
;
I Na,p
;
I Na,t
;
I L high threshold
;
I T low threshold
;
I A
;
I K
;
I M
;
I h
;
I K,Ca
;
I Sodium
;
I Calcium
;
I Potassium
;
I A, slow
;
Na/Ca exchanger
;
I_SERCA
;
Na/K pump
;
Kir
;
Download the displayed file
/
pleiotropy
hay
models
morphologies
Ca_HVA.mod
*
Other models using Ca_HVA.mod:
Layer V pyramidal cell functions and schizophrenia genetics (Mäki-Marttunen et al 2019)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
Schiz.-linked gene effects on intrinsic single-neuron excitability (Maki-Marttunen et al. 2016)
Ca_LVAst.mod
*
Other models using Ca_LVAst.mod:
Layer V pyramidal cell functions and schizophrenia genetics (Mäki-Marttunen et al 2019)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
Schiz.-linked gene effects on intrinsic single-neuron excitability (Maki-Marttunen et al. 2016)
CaDynamics_E2.mod
*
Other models using CaDynamics_E2.mod:
Layer V pyramidal cell functions and schizophrenia genetics (Mäki-Marttunen et al 2019)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
Schiz.-linked gene effects on intrinsic single-neuron excitability (Maki-Marttunen et al. 2016)
epsp.mod
*
Other models using epsp.mod:
Biochemically detailed model of LTP and LTD in a cortical spine (Maki-Marttunen et al 2020)
Biochemically detailed model of LTP and LTD in a cortical spine (Maki-Marttunen et al 2020)
Biochemically detailed model of LTP and LTD in a cortical spine (Maki-Marttunen et al 2020)
Biochemically detailed model of LTP and LTD in a cortical spine (Maki-Marttunen et al 2020)
Biochemically detailed model of LTP and LTD in a cortical spine (Maki-Marttunen et al 2020)
Biochemically detailed model of LTP and LTD in a cortical spine (Maki-Marttunen et al 2020)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Glutamate mediated dendritic and somatic plateau potentials in cortical L5 pyr cells (Gao et al '20)
Impedance spectrum in cortical tissue: implications for LFP signal propagation (Miceli et al. 2017)
L5b PC model constrained for BAC firing and perisomatic current step firing (Hay et al., 2011)
Layer 5 Pyramidal Neuron (Shai et al., 2015)
Layer 5 Pyramidal Neuron (Shai et al., 2015)
Layer V pyramidal cell functions and schizophrenia genetics (Mäki-Marttunen et al 2019)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
Schiz.-linked gene effects on intrinsic single-neuron excitability (Maki-Marttunen et al. 2016)
Sensory-evoked responses of L5 pyramidal tract neurons (Egger et al 2020)
Ih.mod
*
Other models using Ih.mod:
Layer V pyramidal cell functions and schizophrenia genetics (Mäki-Marttunen et al 2019)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
Schiz.-linked gene effects on intrinsic single-neuron excitability (Maki-Marttunen et al. 2016)
Im.mod
*
Other models using Im.mod:
Layer V pyramidal cell functions and schizophrenia genetics (Mäki-Marttunen et al 2019)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
Schiz.-linked gene effects on intrinsic single-neuron excitability (Maki-Marttunen et al. 2016)
K_Pst.mod
*
Other models using K_Pst.mod:
Layer V pyramidal cell functions and schizophrenia genetics (Mäki-Marttunen et al 2019)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
Schiz.-linked gene effects on intrinsic single-neuron excitability (Maki-Marttunen et al. 2016)
K_Tst.mod
*
Other models using K_Tst.mod:
Layer V pyramidal cell functions and schizophrenia genetics (Mäki-Marttunen et al 2019)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
Schiz.-linked gene effects on intrinsic single-neuron excitability (Maki-Marttunen et al. 2016)
Nap_Et2.mod
*
Other models using Nap_Et2.mod:
Layer V pyramidal cell functions and schizophrenia genetics (Mäki-Marttunen et al 2019)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
NaTa_t.mod
*
Other models using NaTa_t.mod:
Layer V pyramidal cell functions and schizophrenia genetics (Mäki-Marttunen et al 2019)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
NaTs2_t.mod
*
Other models using NaTs2_t.mod:
Biochemically detailed model of LTP and LTD in a cortical spine (Maki-Marttunen et al 2020)
Biochemically detailed model of LTP and LTD in a cortical spine (Maki-Marttunen et al 2020)
Biochemically detailed model of LTP and LTD in a cortical spine (Maki-Marttunen et al 2020)
Biochemically detailed model of LTP and LTD in a cortical spine (Maki-Marttunen et al 2020)
Biochemically detailed model of LTP and LTD in a cortical spine (Maki-Marttunen et al 2020)
Biochemically detailed model of LTP and LTD in a cortical spine (Maki-Marttunen et al 2020)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Cortical Layer 5b pyr. cell with [Na+]i mechanisms, from Hay et al 2011 (Zylbertal et al 2017)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Four-pathway phenomenological synaptic plasticity model (Ebner et al. 2019)
Glutamate mediated dendritic and somatic plateau potentials in cortical L5 pyr cells (Gao et al '20)
Human Cortical L5 Pyramidal Cell (Rich et al. 2021)
Hyperexcitability from Nav1.2 channel loss in neocortical pyramidal cells (Spratt et al accepted)
Hyperexcitability from Nav1.2 channel loss in neocortical pyramidal cells (Spratt et al accepted)
L5b PC model constrained for BAC firing and perisomatic current step firing (Hay et al., 2011)
Layer 5 Pyramidal Neuron (Shai et al., 2015)
Layer 5 Pyramidal Neuron (Shai et al., 2015)
Mice Somatosensory L2/3 Pyramidal cells (Iascone et al 2020)
Microcircuits of L5 thick tufted pyramidal cells (Hay & Segev 2015)
Mirror Neuron (Antunes et al 2017)
Sensory-evoked responses of L5 pyramidal tract neurons (Egger et al 2020)
Shaping NMDA spikes by timed synaptic inhibition on L5PC (Doron et al. 2017)
SK_E2.mod
*
Other models using SK_E2.mod:
Layer V pyramidal cell functions and schizophrenia genetics (Mäki-Marttunen et al 2019)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
Schiz.-linked gene effects on intrinsic single-neuron excitability (Maki-Marttunen et al. 2016)
SKv3_1.mod
*
Other models using SKv3_1.mod:
Layer V pyramidal cell functions and schizophrenia genetics (Mäki-Marttunen et al 2019)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
Schiz.-linked gene effects on intrinsic single-neuron excitability (Maki-Marttunen et al. 2016)
calcifcurves.py
calcsteadystate.py
collectfig1.py
collectfig2.py
fig1_curves.mat
fig2_curves.mat
findDCshortthreshold.py
mutation_stuff.py
*
Other models using mutation_stuff.py:
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
mytools.py
*
Other models using mytools.py:
Pleiotropic effects of SCZ-associated genes (Mäki-Marttunen et al. 2017)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
runme.sh
*
Other models using runme.sh:
Pleiotropic effects of SCZ-associated genes (Mäki-Marttunen et al. 2017)
scalings_cs.sav
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