Striatal Spiny Projection Neuron (SPN) plasticity rule (Jedrzejewska-Szmek et al 2016)

 Download zip file 
Help downloading and running models
Accession:189153

Reference:
1 . Jedrzejewska-Szmek J, Damodaran S, Dorman DB, Blackwell KT (2017) Calcium dynamics predict direction of synaptic plasticity in striatal spiny projection neurons. Eur J Neurosci 45:1044-1056 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Dendrite;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s): AMPA; NMDA; GabaA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Calcium dynamics; Synaptic Plasticity;
Implementer(s): Jedrzejewska-Szmek, Joanna ; Damodaran, Sriraman ; Dorman, Daniel B ; Blackwell, Avrama [avrama at gmu.edu];
Search NeuronDB for information about:  GabaA; AMPA; NMDA; Glutamate;
//spineParams.g

       // for spine neck:
float   len_neck=0.5e-6                               //0.16-2.13
float   dia_neck=0.12e-6                             //(0.038-0.46)e-6
       // for spine head:
float   dia_head=0.5e-6                              //adopt common size, no exact data are available now
float   len_head=0.5e-6
      
str spcomp1="head"  //label or name of head compartment in spine
str spcomp2=""  //no separate name/label for neck compartment

int neckSlabs=3
int headSlabs=3
float head_thickness_inc=2.0
float neck_thickness_inc=1.0
float PSD_thick=0.07e-6

float spineRA = RA// SpineHEAD
float neckRA = 11.3// Results in spine neck Ra = .5 Gohm
//float spineRa=0.5e9 //DBD: changed from spineRA=4*RA to spineRa .5e9 based on IV/IF tuning
float spineRM=RM
float spineCM=CM

float spineStart=26.1e-6
float spineEnd=300e-6
float spineDensity=0.8//0.3 //in units of per micron

int addCa2Spine = 1		// 0, no VDCC in spine, 
					//1, yes VDCC in spine (non-synaptic)

int spinecalcium = 0   // We have two types of caclium:
                   // 0 : detailed multi-shell model, using "difshell" object
                   // 1 : simple calcium pool adopted from Sabatini's 2001, 2004
if ({spinecalcium<calciumtype})
	echo "bad idea; use difshells for spine or single for dendrites"
end

//for calcium and buffer diffusion messages between spine neck and dendrite.  
str upperShell = {CalciumName} @ 1

//  define spine specific calcium values here, and use them in spines.g

float gCaL12spine       =      {getglobal gCaL12dend_{DA}} //3.35e-7
float gCaL13spine       =      {getglobal gCaL13dend_{DA}} //4.25e-7
float gCaRspine         =      {gCaRdend}   //13e-7
float gCaTspine         =      {gCaTdist}   //0.235e-7

float kcatSpine =  1e-8 //75e-8
float kcatSpineNCX = 8e-8  //300e-8