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Multitarget pharmacology for Dystonia in M1 (Neymotin et al 2016)
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Model Information
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Accession:
189154
" ... We developed a multiscale model of primary motor cortex, ranging from molecular, up to cellular, and network levels, containing 1715 compartmental model neurons with multiple ion channels and intracellular molecular dynamics. We wired the model based on electrophysiological data obtained from mouse motor cortex circuit mapping experiments. We used the model to reproduce patterns of heightened activity seen in dystonia by applying independent random variations in parameters to identify pathological parameter sets. ..."
Reference:
1 .
Neymotin SA, Dura-Bernal S, Lakatos P, Sanger TD, Lytton WW (2016) Multitarget Multiscale Simulation for Pharmacological Treatment of Dystonia in Motor Cortex.
Front Pharmacol
7
:157
[
PubMed
]
Citations
Citation Browser
Model Information
(Click on a link to find other models with that property)
Model Type:
Realistic Network;
Molecular Network;
Brain Region(s)/Organism:
Neocortex;
Cell Type(s):
Neocortex L5/6 pyramidal GLU cell;
Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell;
Neocortex V1 interneuron basket PV GABA cell;
Neocortex fast spiking (FS) interneuron;
Neocortex spiking regular (RS) neuron;
Neocortex spiking low threshold (LTS) neuron;
Neocortex layer 4 neuron;
Neocortex layer 2-3 interneuron;
Neocortex layer 4 interneuron;
Neocortex layer 5 interneuron;
Neocortex layer 6a interneuron;
Channel(s):
I A;
I h;
I_SERCA;
Ca pump;
I K,Ca;
I Calcium;
I L high threshold;
I T low threshold;
I N;
I_KD;
I M;
I Na,t;
Gap Junctions:
Receptor(s):
GabaA;
GabaB;
AMPA;
mGluR;
Gene(s):
HCN1;
Transmitter(s):
Gaba;
Glutamate;
Simulation Environment:
NEURON;
Python;
Model Concept(s):
Oscillations;
Activity Patterns;
Beta oscillations;
Reaction-diffusion;
Calcium dynamics;
Pathophysiology;
Multiscale;
Implementer(s):
Neymotin, Sam [Samuel.Neymotin at nki.rfmh.org];
Dura-Bernal, Salvador [salvadordura at gmail.com];
Search NeuronDB
for information about:
Neocortex L5/6 pyramidal GLU cell
;
Neocortex V1 interneuron basket PV GABA cell
;
Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell
;
GabaA
;
GabaB
;
AMPA
;
mGluR
;
I Na,t
;
I L high threshold
;
I N
;
I T low threshold
;
I A
;
I M
;
I h
;
I K,Ca
;
I Calcium
;
I_SERCA
;
I_KD
;
Ca pump
;
Gaba
;
Glutamate
;
/
dystdemo
readme.txt
cagk.mod
*
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Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
cal.mod
*
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Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
calts.mod
*
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Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
can.mod
*
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Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
cat.mod
*
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Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
gabab.mod
h_winograd.mod
HCN1.mod
IC.mod
*
Other models using IC.mod:
Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
icalts.mod
*
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Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
ihlts.mod
*
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Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
kap.mod
kcalts.mod
*
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Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
kdmc.mod
kdr.mod
km.mod
*
Other models using km.mod:
Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
mglur.mod
*
Other models using mglur.mod:
Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
misc.mod
*
Other models using misc.mod:
Computer models of corticospinal neurons replicate in vitro dynamics (Neymotin et al. 2017)
Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
Neuronal dendrite calcium wave model (Neymotin et al, 2015)
MyExp2SynBB.mod
*
Other models using MyExp2SynBB.mod:
CA3 Network Model of Epileptic Activity (Sanjay et. al, 2015)
Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
Ketamine disrupts theta modulation of gamma in a computer model of hippocampus (Neymotin et al 2011)
MyExp2SynNMDABB.mod
nax.mod
stats.mod
*
Other models using stats.mod:
Cortical model with reinforcement learning drives realistic virtual arm (Dura-Bernal et al 2015)
Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
Neuronal dendrite calcium wave model (Neymotin et al, 2015)
Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013)
vecst.mod
*
Other models using vecst.mod:
Boolean network-based analysis of the apoptosis network (Mai and Liu 2009)
Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
Computational Surgery (Lytton et al. 2011)
Computer models of corticospinal neurons replicate in vitro dynamics (Neymotin et al. 2017)
Cortical model with reinforcement learning drives realistic virtual arm (Dura-Bernal et al 2015)
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Neuronal dendrite calcium wave model (Neymotin et al, 2015)
Prosthetic electrostimulation for information flow repair in a neocortical simulation (Kerr 2012)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013)
Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
aux_fun.inc
*
Other models using aux_fun.inc:
CA3 Network Model of Epileptic Activity (Sanjay et. al, 2015)
Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
Ketamine disrupts theta modulation of gamma in a computer model of hippocampus (Neymotin et al 2011)
conf.py
declist.hoc
*
Other models using declist.hoc:
Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
Cortical model with reinforcement learning drives realistic virtual arm (Dura-Bernal et al 2015)
In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
decnqs.hoc
*
Other models using decnqs.hoc:
Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
Cortical model with reinforcement learning drives realistic virtual arm (Dura-Bernal et al 2015)
In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
decvec.hoc
*
Other models using decvec.hoc:
Boolean network-based analysis of the apoptosis network (Mai and Liu 2009)
Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
Cortical model with reinforcement learning drives realistic virtual arm (Dura-Bernal et al 2015)
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013)
Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
default.hoc
*
Other models using default.hoc:
Boolean network-based analysis of the apoptosis network (Mai and Liu 2009)
CA3 Network Model of Epileptic Activity (Sanjay et. al, 2015)
Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
Computational Surgery (Lytton et al. 2011)
Cortical model with reinforcement learning drives realistic virtual arm (Dura-Bernal et al 2015)
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Emergence of physiological oscillation frequencies in neocortex simulations (Neymotin et al. 2011)
Hopfield and Brody model (Hopfield, Brody 2000) (NEURON+python)
Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
Ketamine disrupts theta modulation of gamma in a computer model of hippocampus (Neymotin et al 2011)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Prosthetic electrostimulation for information flow repair in a neocortical simulation (Kerr 2012)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013)
Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
drline.hoc
*
Other models using drline.hoc:
Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
Cortical model with reinforcement learning drives realistic virtual arm (Dura-Bernal et al 2015)
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Prosthetic electrostimulation for information flow repair in a neocortical simulation (Kerr 2012)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013)
Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
geom.py
ghk.inc
*
Other models using ghk.inc:
Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
grvec.hoc
*
Other models using grvec.hoc:
In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
init.hoc
labels.hoc
*
Other models using labels.hoc:
In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
labels.py
*
Other models using labels.py:
Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
local.hoc
*
Other models using local.hoc:
Boolean network-based analysis of the apoptosis network (Mai and Liu 2009)
CA3 Network Model of Epileptic Activity (Sanjay et. al, 2015)
Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
Computational Surgery (Lytton et al. 2011)
Cortical model with reinforcement learning drives realistic virtual arm (Dura-Bernal et al 2015)
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Emergence of physiological oscillation frequencies in neocortex simulations (Neymotin et al. 2011)
Hopfield and Brody model (Hopfield, Brody 2000) (NEURON+python)
Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
Ketamine disrupts theta modulation of gamma in a computer model of hippocampus (Neymotin et al 2011)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Prosthetic electrostimulation for information flow repair in a neocortical simulation (Kerr 2012)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
misc.h
mpisim.py
netcfg.cfg
nqs.hoc
*
Other models using nqs.hoc:
Cortical model with reinforcement learning drives realistic virtual arm (Dura-Bernal et al 2015)
In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
nqs.py
nrnoc.hoc
*
Other models using nrnoc.hoc:
Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
pyinit.py
*
Other models using pyinit.py:
Boolean network-based analysis of the apoptosis network (Mai and Liu 2009)
Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
python.hoc
*
Other models using python.hoc:
Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
pywrap.hoc
*
Other models using pywrap.hoc:
Boolean network-based analysis of the apoptosis network (Mai and Liu 2009)
Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
Cortical model with reinforcement learning drives realistic virtual arm (Dura-Bernal et al 2015)
In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013)
simctrl.hoc
*
Other models using simctrl.hoc:
Boolean network-based analysis of the apoptosis network (Mai and Liu 2009)
CA3 Network Model of Epileptic Activity (Sanjay et. al, 2015)
Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
Computational Surgery (Lytton et al. 2011)
Computer model of clonazepam`s effect in thalamic slice (Lytton 1997)
Cortical model with reinforcement learning drives realistic virtual arm (Dura-Bernal et al 2015)
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Emergence of physiological oscillation frequencies in neocortex simulations (Neymotin et al. 2011)
Feedforward heteroassociative network with HH dynamics (Lytton 1998)
Hippocampus temporo-septal engram shift model (Lytton 1999)
Hopfield and Brody model (Hopfield, Brody 2000) (NEURON+python)
Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
Ketamine disrupts theta modulation of gamma in a computer model of hippocampus (Neymotin et al 2011)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Prosthetic electrostimulation for information flow repair in a neocortical simulation (Kerr 2012)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013)
Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
Thalamic quiescence of spike and wave seizures (Lytton et al 1997)
simdat.py
syn.py
syncode.hoc
*
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Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
Cortical model with reinforcement learning drives realistic virtual arm (Dura-Bernal et al 2015)
Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013)
vector.py
*
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Neuronal dendrite calcium wave model (Neymotin et al, 2015)
xgetargs.hoc
*
Other models using xgetargs.hoc:
Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
Cortical model with reinforcement learning drives realistic virtual arm (Dura-Bernal et al 2015)
In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
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