Functional properties of dendritic gap junctions in Cerebellar Golgi cells (Szoboszlay et al. 2016)

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Accession:189186
" ... We investigated the properties of gap junctions in cerebellar interneurons by combining paired somato-somatic and somato-dendritic recordings, anatomical reconstructions, immunohistochemistry, electron microscopy, and modeling. By fitting detailed compartmental models of Golgi cells to their somato-dendritic voltage responses, we determined their passive electrical properties and the mean gap junction conductance (0.9 nS). ..."
Reference:
1 . Szoboszlay M, Lorincz A, Lanore F, Vervaeke K, Silver RA, Nusser Z (2016) Functional Properties of Dendritic Gap Junctions in Cerebellar Golgi Cells. Neuron 90:1043-56 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Cerebellum golgi cell;
Channel(s):
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; neuroConstruct;
Model Concept(s):
Implementer(s): Szoboszlay, M [szoboszlay.miklos at koki.mta.hu];
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Golgi
02_Somatic_paired_recordings
140624-C0
gapCond.mod *
auto_fitting.ses
auto_fitting.ses.fd1
auto_fitting.ses.fd2
auto_fitting.ses.ft1
auto_fitting.ses.ft2
biophys.hoc *
cellCheck.hoc *
init.hoc *
init_auto_fitting.hoc
morphology_140624_C0_blue.hoc
morphology_140624_C0_blue_noDL.hoc
morphology_140624_C0_red.hoc
morphology_140624_C0_red_noDL.hoc
nCtools.hoc *
parameters.hoc
Passive_GoC_membrane_kinetics_1.hoc
Passive_GoC_membrane_kinetics_10.hoc
Passive_GoC_membrane_kinetics_2.hoc
Passive_GoC_membrane_kinetics_3.hoc
Passive_GoC_membrane_kinetics_4.hoc
Passive_GoC_membrane_kinetics_5.hoc
Passive_GoC_membrane_kinetics_6.hoc
Passive_GoC_membrane_kinetics_7.hoc
Passive_GoC_membrane_kinetics_8.hoc
Passive_GoC_membrane_kinetics_9.hoc
processes.hoc *
                            
celsius = 23
gapWeight = 1000

user_Rm_b = 1e4		// Ohm*cm2
user_Rm_r = 1e4		// Ohm*cm2

user_e_pas = 0		// mV
user_cm_b = 1		// uF/cm2
user_cm_r = 1		// uF/cm2

user_Ra_b = 92		//Ohm*cm
user_Ra_r = 92		//Ohm*cm

tstop = 700			// ms

isCVodeAct = 1
isStim1 = 1
isStim2 = 0

//IC into the soma and dendrites
objref stim1, stim2, stim3, stim4

morphology_140624_C0_blue[0].soma_b stim1 = new IClamp(0.5)

stim1.amp = 0.2		// nA
stim1.dur = 2		// ms
stim1.del = 20		// ms

morphology_140624_C0_blue[0].soma_b stim2 = new IClamp(0.5)

stim2.amp = 0.05	// nA
stim2.dur = 400		// ms
stim2.del = 100		// ms

morphology_140624_C0_red[0].soma_r stim3 = new IClamp(0.5)

stim3.amp = 0.2		// nA
stim3.dur = 2		// ms
stim3.del = 20		// ms

morphology_140624_C0_red[0].soma_r stim4 = new IClamp(0.5)

stim4.amp = 0.05	// nA
stim4.dur = 400		// ms
stim4.del = 100		// ms