Functional properties of dendritic gap junctions in Cerebellar Golgi cells (Szoboszlay et al. 2016)

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Accession:189186
" ... We investigated the properties of gap junctions in cerebellar interneurons by combining paired somato-somatic and somato-dendritic recordings, anatomical reconstructions, immunohistochemistry, electron microscopy, and modeling. By fitting detailed compartmental models of Golgi cells to their somato-dendritic voltage responses, we determined their passive electrical properties and the mean gap junction conductance (0.9 nS). ..."
Reference:
1 . Szoboszlay M, Lorincz A, Lanore F, Vervaeke K, Silver RA, Nusser Z (2016) Functional Properties of Dendritic Gap Junctions in Cerebellar Golgi Cells. Neuron 90:1043-56 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Cerebellum golgi cell;
Channel(s):
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; neuroConstruct;
Model Concept(s):
Implementer(s): Szoboszlay, M [szoboszlay.miklos at koki.mta.hu];
/
Golgi
01_Soma-dendritic_recordings
01_Control
140311-C1
syncytium
num10
gapCond.mod *
biophys.hoc *
cellCheck.hoc *
fitting.ses
fitting.ses.fd1 *
fitting.ses.ft1
init.hoc *
init_auto_fitting.hoc *
init_fitting.hoc *
morphology_140311_C1.hoc *
nCtools.hoc *
Passive_GoC_membrane_kinetics.hoc
processes.hoc *
                            
COMMENT

   **************************************************
   File generated by: neuroConstruct v1.6.0 
   **************************************************

   This file holds the implementation in NEURON of the Cell Mechanism:
   gapCond (Type: Gap junction, Model: File Based Membrane Mechanism)

   with parameters: 

ENDCOMMENT

COMMENT

   **************************************************
   File generated by: neuroConstruct v1.6.0 
   **************************************************

   This file holds the implementation in NEURON of the Cell Mechanism:
   gapCond (Type: Gap junction, Model: File Based Membrane Mechanism)

   with parameters: 

ENDCOMMENT

COMMENT

   **************************************************
   File generated by: neuroConstruct v1.5.3 
   **************************************************

   This file holds the implementation in NEURON of the Cell Mechanism:
   GJ (Type: Gap junction, Model: File Based Membrane Mechanism)

   with parameters: 

ENDCOMMENT

COMMENT

   **************************************************
   File generated by: neuroConstruct v1.5.0 
   **************************************************


ENDCOMMENT


?  This is a NEURON mod file generated from a ChannelML file

?  Unit system of original ChannelML file: Physiological Units

COMMENT
    ChannelML file describing a single synaptic mechanism
ENDCOMMENT

? Creating synaptic mechanism for an electrical synapse
    

TITLE Channel: GapJuncCML

COMMENT
    Description of an electrical synapse at a gap junction
ENDCOMMENT


UNITS {
    (nA) = (nanoamp)
    (mV) = (millivolt)
    (uS) = (microsiemens)
}

    
NEURON {
    POINT_PROCESS gapCond
    NONSPECIFIC_CURRENT i
    RANGE g, i
    RANGE weight
    
    POINTER vgap  : Using a POINTER as opposed to RANGE for serial mode
        

}

PARAMETER {
    v (millivolt)
    vgap (millivolt)
    g = 1e-6 (microsiemens)
    weight = 1

}


ASSIGNED {
    i (nanoamp)
}

BREAKPOINT {
    i = weight * g * (v - vgap)
}