/*
Template file for a single compartment model of a thalamocortical neuron modified from the model described by Destexhe et al, 1995.
Destexhe, A., Bal, T., McCormick, D.A. and Sejnowski, T.J.
Ionic mechanisms underlying synchronized oscillations and propagating
waves in a model of ferret thalamic slices. Journal of Neurophysiology
76: 2049-2070, 1996.
See also http://www.cnl.salk.edu/~alain , http://cns.fmed.ulaval.ca
*/
begintemplate sTC // create a new template object
public soma , kl
create soma[1] // one compartment of about 29000 um2
soma {
nseg = 1
diam = 96
L = 96
cm = 1
}
objectvar kl
proc init() { local v_potassium, v_sodium
objectvar kl
kl = new kleak()
v_potassium = -100 // potassium reversal potential
v_sodium = 50 // sodium reversal potential
soma {
diam = 96 // geometry
L = 96 // so that area is about 29000 um2
nseg = 1
Ra = 100
insert pas // leak current
e_pas = -70 // from Rinzel
g_pas = 1e-5
kl.loc(0.5) // K-leak
Erev_kleak = v_potassium
kl.gmax = 0.004 // (uS)
// conversion: x(uS) = x(mS/cm2)*29000e-8*1e3
// = x(mS/cm2) * 0.29
insert hh2 // Hodgin-Huxley INa and IK
ek = v_potassium
ena = v_sodium
vtraub_hh2 = -25 // High threshold to simulated IA
gnabar_hh2 = 0.09
gkbar_hh2 = 0.01
insert hcn2 // model for HCN2 current
gbar_hcn2 = 0.01 // maximal conductance
a_hcn2 = 40e-9 // cAMP concentration
gca_hcn2 = 1 // relative conductance of the bound state
shift_hcn2 = 48 // shift in voltage dependence
}
}
endtemplate sTC
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