CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)

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We developed a CA1 pyramidal cell model calibrated with a broad spectrum of in vitro data. Using simultaneous dendritic and somatic recordings, and combining results for two different response measures (peak vs. mean EPSP), two different stimulus formats (single shock vs. 50 Hz trains), and two different spatial integration conditions (within vs. between-branch summation), we found the cell's subthreshold responses to paired inputs are best described as a sum of nonlinear subunit responses, where the subunits correspond to different dendritic branches. In addition to suggesting a new type of experiment and providing testable predictions, our model shows how conclusions regarding synaptic arithmetic can be influenced by an array of seemingly innocuous experimental design choices.
1 . Poirazi P, Brannon T, Mel BW (2003) Arithmetic of subthreshold synaptic summation in a model CA1 pyramidal cell. Neuron 37:977-87 [PubMed]
2 . Poirazi P, Brannon T, Mel BW (2003) Pyramidal neuron as two-layer neural network. Neuron 37:989-99 [PubMed]
3 . Poirazi P, Brannon T, Mel BW (2003ab-sup) Online Supplement: About the Model Neuron 37 Online:1-20
4 . Polsky A, Mel BW, Schiller J (2004) Computational subunits in thin dendrites of pyramidal cells. Nat Neurosci 7:621-7 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I K,Ca; I Calcium;
Gap Junctions:
Receptor(s): GabaA; GabaB; NMDA; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Activity Patterns; Dendritic Action Potentials; Active Dendrites; Influence of Dendritic Geometry; Detailed Neuronal Models; Action Potentials; Depression; Delay;
Implementer(s): Poirazi, Panayiota [poirazi at];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; GabaA; GabaB; NMDA; Glutamate; I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I K,Ca; I Calcium;
apical-non-trunk-list.hoc *
apical-tip-list.hoc *
apical-tip-list-addendum.hoc *
apical-trunk-list.hoc *
axon-sec-list.hoc *
basal-paths.hoc *
basal-tree-list.hoc *
cell.hoc *
cell-analysis.hoc *
gabab-gabaa-uniform-ratio.hoc *
n123.hoc *
nmda-ampa-ratio.hoc *
oblique-paths.hoc *
peri-trunk-list.hoc *
soma-list.hoc *
// This function makes a list with primary oblique dendrites
// written by Yiota Poirazi, July 2001,

objref apical_tip_list
apical_tip_list=new SectionList()

// List of obliques located at distances approximatelly less than 300 microns from the soma

proc proximals() {

  apical_dendrite[3]    apical_tip_list.append()   // 1 degree                 74.4  microns from soma
  apical_dendrite[5]    apical_tip_list.append()   // 0 degree                 57.46 (vertical distance)
  apical_dendrite[24]   apical_tip_list.append()   // 0 degree                 92.05
  apical_dendrite[30]   apical_tip_list.append()   // 0 degree  (essentially) 153.44
  apical_dendrite[34]   apical_tip_list.append()   // 2 degrees (ignore 3rd)  215.06
  apical_dendrite[45]   apical_tip_list.append()   // 0 degree. (essentially) 170.32
  apical_dendrite[51]   apical_tip_list.append()   // 2 degrees               210.93
  apical_dendrite[59]   apical_tip_list.append()   //                         189.34
  apical_dendrite[61]   apical_tip_list.append()   //                         221.55
  apical_dendrite[63]   apical_tip_list.append()   //                         231.58
  apical_dendrite[68]   apical_tip_list.append()   // 2 degrees               277.48
  apical_dendrite[70]   apical_tip_list.append()   // 0 degree                300.94
  apical_dendrite[106]  apical_tip_list.append()   // 0 degree                258.05
  apical_dendrite[107]  apical_tip_list.append()   // 0 degree                159.55      
  apical_dendrite[111]  apical_tip_list.append()   // 1 degree                106.30
  apical_dendrite[112]  apical_tip_list.append()   // 0 degree                 88.52
  apical_dendrite[115]  apical_tip_list.append()   // 1 degree                117.79
  apical_dendrite[118]  apical_tip_list.append()   // 0 degree                 81.66

// List of obliques located beyond 300 microns from the soma

proc distals() {    
  apical_dendrite[73]   apical_tip_list.append()   // 0 degree                334.84 
  apical_dendrite[82]   apical_tip_list.append()   // 0 degree                360.28
  apical_dendrite[86]   apical_tip_list.append()   // 0 degree                419.68
  apical_dendrite[93]   apical_tip_list.append()   // 0 degree                468.60
  apical_dendrite[97]   apical_tip_list.append()   // 0 degree                445.90
  apical_dendrite[105]  apical_tip_list.append()   // 0 degree                425.58


/* Make a shape graph with apical oblique dendrites
objref apical_tip_list_shape
color_index = 2
apical_tip_list_shape=new Shape()