CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)

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Accession:206244
In our experimental study, we combined paired patch-clamp recordings and two-photon Ca2+ imaging to quantify inhibition exerted by individual GABAergic contacts on hippocampal pyramidal cell dendrites. We observed that Ca2+ transients from back-propagating action potentials were significantly reduced during simultaneous activation of individual nearby GABAergic synapses. To simulate dendritic Ca2+ inhibition by individual GABAergic synapses, we employed a multi-compartmental CA1 pyramidal cell model with detailed morphology, voltage-gated channel distributions, and calcium dynamics, based with modifications on the model of Poirazi et al., 2003, modelDB accession # 20212.
Reference:
1 . Müllner FE, Wierenga CJ, Bonhoeffer T (2015) Precision of Inhibition: Dendritic Inhibition by Individual GABAergic Synapses on Hippocampal Pyramidal Cells Is Confined in Space and Time. Neuron 87:576-89 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Calcium; I Sodium; I Potassium; I h;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s): Gaba;
Simulation Environment: NEURON;
Model Concept(s): Action Potentials; Dendritic Action Potentials; Active Dendrites; Calcium dynamics;
Implementer(s): Muellner, Fiona E [fiona.muellner at gmail.com];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; I h; I Sodium; I Calcium; I Potassium; Gaba; 
% Compare temporal profiles of simulated Ca2+-inhibition
% ---
% Fiona Müllner, MPI Neurobiology
% Email: fiona.muellner at gmail.com

clearvars -except rootfolder
cd(sprintf('%s\\CA1_multi\\experiment\\regular',rootfolder))
TemporalProfile
xdata=-1:0.1:5;
gmax = 1;
onset = -1;
tau = 1;
alphasynapse = max(0,gmax * (xdata - onset)/tau .* exp(-(xdata - onset - tau)/tau));
plot(xdata(end:-1:1)-4,alphasynapse,'k','Linewidth',3)
title('1x APs with tau = 1, compared to flipped conductance')
xlabel('time [ms]')
ylabel('Ca2+ inhibition')

cd(sprintf('%s\\CA1_multi\\experiment\\triple',rootfolder))
TemporalProfile
title('3x APs with tau = 1ms')
xlabel('time [ms]')
ylabel('Ca2+ inhibition')

cd(sprintf('%s\\CA1_multi\\experiment\\triple_tau3',rootfolder))
TemporalProfile
title('3x APs with tau = 3ms')
xlabel('time [ms]')
ylabel('Ca2+ inhibition')