CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)

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In our experimental study, we combined paired patch-clamp recordings and two-photon Ca2+ imaging to quantify inhibition exerted by individual GABAergic contacts on hippocampal pyramidal cell dendrites. We observed that Ca2+ transients from back-propagating action potentials were significantly reduced during simultaneous activation of individual nearby GABAergic synapses. To simulate dendritic Ca2+ inhibition by individual GABAergic synapses, we employed a multi-compartmental CA1 pyramidal cell model with detailed morphology, voltage-gated channel distributions, and calcium dynamics, based with modifications on the model of Poirazi et al., 2003, modelDB accession # 20212.
1 . Müllner FE, Wierenga CJ, Bonhoeffer T (2015) Precision of Inhibition: Dendritic Inhibition by Individual GABAergic Synapses on Hippocampal Pyramidal Cells Is Confined in Space and Time. Neuron 87:576-89 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Calcium; I Sodium; I Potassium; I h;
Gap Junctions:
Transmitter(s): Gaba;
Simulation Environment: NEURON;
Model Concept(s): Action Potentials; Dendritic Action Potentials; Active Dendrites; Calcium dynamics;
Implementer(s): Muellner, Fiona E [fiona.muellner at];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; I h; I Sodium; I Calcium; I Potassium; Gaba;
apical-non-trunk-list.hoc *
apical-tip-list.hoc *
apical-tip-list-addendum.hoc *
apical-trunk-list.hoc *
axon-sec-list.hoc *
basal-paths.hoc *
basal-tree-list.hoc *
cell.hoc *
cell-analysis.hoc *
n123.hoc *
peri-trunk-list.hoc *
soma-list.hoc *
// This function makes a list with oblique branches in addition to 
// the primary list in apical-tip-list.hoc 
// written by Yiota Poirazi, July 2001,

objref apical_tip_list_addendum
apical_tip_list_addendum=new SectionList()

//    SISTER of apical_dendrite[3]   is apical_dendrite[2]    
//    SISTER of apical_dendrite[34]  is apical_dendrite[33]   
//    SISTER of apical_dendrite[37]  is apical_dendrite[36]   
//    SISTER of apical_dendrite[40]  is apical_dendrite[39]
//    SISTER of apical_dendrite[45]  is apical_dendrite[44]
//    SISTER of apical_dendrite[54]  is apical_dendrite[53] 
//    SISTER of apical_dendrite[68]  is apical_dendrite[67] 
//    SISTER of apical_dendrite[111] is apical_dendrite[110] 
//    SISTER of apical_dendrite[115] is apical_dendrite[114] 
//    SISTER of apical_dendrite[118] is apical_dendrite[117] 

  apical_dendrite[2]    apical_tip_list_addendum.append()  // 1 degree      69.9821  microns from soma
  apical_dendrite[33]   apical_tip_list_addendum.append()  // 2 degrees    177.4831 (vertical distance)
  apical_dendrite[36]   apical_tip_list_addendum.append()  // 2 degree     189.0447 
  apical_dendrite[37]   apical_tip_list_addendum.append()  // 2 degrees    180.5792 
  apical_dendrite[39]   apical_tip_list_addendum.append()  // 1 degree      83.7030
  apical_dendrite[40]   apical_tip_list_addendum.append()  // 1 degreee    102.6654
  apical_dendrite[44]   apical_tip_list_addendum.append()  // 0 degree     172.7760 
  apical_dendrite[47]   apical_tip_list_addendum.append()  // 0 degree.    177.4980
  apical_dendrite[53]   apical_tip_list_addendum.append()  // 3 degrees    202.8910
  apical_dendrite[54]   apical_tip_list_addendum.append()  // 3 degrees    190.3009
  apical_dendrite[67]   apical_tip_list_addendum.append()  // 2 degrees    289.5367   
  apical_dendrite[110]  apical_tip_list_addendum.append()  // 1 degree      98.7392
  apical_dendrite[114]  apical_tip_list_addendum.append()  // 1 degree     123.9962
  apical_dendrite[117]  apical_tip_list_addendum.append()  // 0 degree      67.6363

//  forsec apical_tip_list_addendum {
//    apical_tip_list.append()
//  }

/* Make a shape graph with the additional oblique branches

objref apical_tip_list_addendum_shape
color_index = 3
apical_tip_list_addendum_shape=new Shape()