CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)

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Accession:206244
In our experimental study, we combined paired patch-clamp recordings and two-photon Ca2+ imaging to quantify inhibition exerted by individual GABAergic contacts on hippocampal pyramidal cell dendrites. We observed that Ca2+ transients from back-propagating action potentials were significantly reduced during simultaneous activation of individual nearby GABAergic synapses. To simulate dendritic Ca2+ inhibition by individual GABAergic synapses, we employed a multi-compartmental CA1 pyramidal cell model with detailed morphology, voltage-gated channel distributions, and calcium dynamics, based with modifications on the model of Poirazi et al., 2003, modelDB accession # 20212.
Reference:
1 . Müllner FE, Wierenga CJ, Bonhoeffer T (2015) Precision of Inhibition: Dendritic Inhibition by Individual GABAergic Synapses on Hippocampal Pyramidal Cells Is Confined in Space and Time. Neuron 87:576-89 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Calcium; I Sodium; I Potassium; I h;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s): Gaba;
Simulation Environment: NEURON;
Model Concept(s): Action Potentials; Dendritic Action Potentials; Active Dendrites; Calcium dynamics;
Implementer(s): Muellner, Fiona E [fiona.muellner at gmail.com];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; I h; I Sodium; I Calcium; I Potassium; Gaba;
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CA1_multi
morphology
n123
apical-non-trunk-list.hoc *
apical-tip-list.hoc *
apical-tip-list-addendum.hoc *
apical-trunk-list.hoc *
axon-sec-list.hoc *
basal-paths.hoc *
basal-tree-list.hoc *
cell.hoc *
cell_+spine.hoc
cell_+spine_multi.hoc
cell_div2.hoc
cell_mul2.hoc
cell-analysis.hoc *
cell-analysis_div2.hoc
cell-analysis_mul2.hoc
n123.hoc *
oblique-paths.hoc
peri-trunk-list.hoc *
soma-list.hoc *
                            
// This function makes a list with primary oblique dendrites
// written by Yiota Poirazi, July 2001, poirazi@LNC.usc.edu

objref apical_tip_list
apical_tip_list=new SectionList()

// List of obliques located at distances approximatelly less than 300 microns from the soma

proc proximals() {

  apical_dendrite[3]    apical_tip_list.append()   // 1 degree                 74.4  microns from soma
  apical_dendrite[5]    apical_tip_list.append()   // 0 degree                 57.46 (vertical distance)
  apical_dendrite[24]   apical_tip_list.append()   // 0 degree                 92.05
  apical_dendrite[30]   apical_tip_list.append()   // 0 degree  (essentially) 153.44
  apical_dendrite[34]   apical_tip_list.append()   // 2 degrees (ignore 3rd)  215.06
  apical_dendrite[45]   apical_tip_list.append()   // 0 degree. (essentially) 170.32
  apical_dendrite[51]   apical_tip_list.append()   // 2 degrees               210.93
  apical_dendrite[59]   apical_tip_list.append()   //                         189.34
  apical_dendrite[61]   apical_tip_list.append()   //                         221.55
  apical_dendrite[63]   apical_tip_list.append()   //                         231.58
  apical_dendrite[68]   apical_tip_list.append()   // 2 degrees               277.48
  apical_dendrite[70]   apical_tip_list.append()   // 0 degree                300.94
  apical_dendrite[106]  apical_tip_list.append()   // 0 degree                258.05
  apical_dendrite[107]  apical_tip_list.append()   // 0 degree                159.55      
  apical_dendrite[111]  apical_tip_list.append()   // 1 degree                106.30
  apical_dendrite[112]  apical_tip_list.append()   // 0 degree                 88.52
  apical_dendrite[115]  apical_tip_list.append()   // 1 degree                117.79
  apical_dendrite[118]  apical_tip_list.append()   // 0 degree                 81.66
}

// List of obliques located beyond 300 microns from the soma

proc distals() {    
  apical_dendrite[73]   apical_tip_list.append()   // 0 degree                334.84 
  apical_dendrite[82]   apical_tip_list.append()   // 0 degree                360.28
  apical_dendrite[86]   apical_tip_list.append()   // 0 degree                419.68
  apical_dendrite[93]   apical_tip_list.append()   // 0 degree                468.60
  apical_dendrite[97]   apical_tip_list.append()   // 0 degree                445.90
  apical_dendrite[105]  apical_tip_list.append()   // 0 degree                425.58
}

proximals()
distals()

/* Make a shape graph with apical oblique dendrites
objref apical_tip_list_shape
color_index = 2
apical_tip_list_shape=new Shape()
apical_tip_list_shape.color_list(apical_tip_list,color_index)
apical_tip_list_shape.action("secname()")
apical_tip_list_shape.printfile("apical-tip-list.eps")
*/