CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)

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In our experimental study, we combined paired patch-clamp recordings and two-photon Ca2+ imaging to quantify inhibition exerted by individual GABAergic contacts on hippocampal pyramidal cell dendrites. We observed that Ca2+ transients from back-propagating action potentials were significantly reduced during simultaneous activation of individual nearby GABAergic synapses. To simulate dendritic Ca2+ inhibition by individual GABAergic synapses, we employed a multi-compartmental CA1 pyramidal cell model with detailed morphology, voltage-gated channel distributions, and calcium dynamics, based with modifications on the model of Poirazi et al., 2003, modelDB accession # 20212.
1 . Müllner FE, Wierenga CJ, Bonhoeffer T (2015) Precision of Inhibition: Dendritic Inhibition by Individual GABAergic Synapses on Hippocampal Pyramidal Cells Is Confined in Space and Time. Neuron 87:576-89 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Calcium; I Sodium; I Potassium; I h;
Gap Junctions:
Transmitter(s): Gaba;
Simulation Environment: NEURON;
Model Concept(s): Action Potentials; Dendritic Action Potentials; Active Dendrites; Calcium dynamics;
Implementer(s): Muellner, Fiona E [fiona.muellner at];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; I h; I Sodium; I Calcium; I Potassium; Gaba;
apical-non-trunk-list.hoc *
apical-tip-list.hoc *
apical-tip-list-addendum.hoc *
apical-trunk-list.hoc *
axon-sec-list.hoc *
basal-paths.hoc *
basal-tree-list.hoc *
cell.hoc *
cell-analysis.hoc *
n123.hoc *
peri-trunk-list.hoc *
soma-list.hoc *
// This function makes a list with all dendritic sections in the apical trunk
// written by Yiota Poirazi, July 2001,

objref apical_trunk_list
apical_trunk_list=new SectionList()

apical_dendrite[0]  apical_trunk_list.append() // 13.40  microns from soma 
apical_dendrite[4]  apical_trunk_list.append() // 46.03 (vertical distance)
apical_dendrite[6]  apical_trunk_list.append() // 45.75
apical_dendrite[14] apical_trunk_list.append() // 52.53
apical_dendrite[15] apical_trunk_list.append() // 58.97
apical_dendrite[16] apical_trunk_list.append() // 70.89
apical_dendrite[22] apical_trunk_list.append() // 72.93
apical_dendrite[23] apical_trunk_list.append() // 74.48
apical_dendrite[25] apical_trunk_list.append() // 93.56
apical_dendrite[26] apical_trunk_list.append() // 98.55
apical_dendrite[27] apical_trunk_list.append() // 121.89
apical_dendrite[41] apical_trunk_list.append() // 144.46
apical_dendrite[42] apical_trunk_list.append() // 142.81
apical_dendrite[46] apical_trunk_list.append() // 156.96
apical_dendrite[48] apical_trunk_list.append() // 162.99
apical_dendrite[56] apical_trunk_list.append() // 179.58
apical_dendrite[58] apical_trunk_list.append() // 180.11
apical_dendrite[60] apical_trunk_list.append() // 210.33
apical_dendrite[62] apical_trunk_list.append() // 222.80
apical_dendrite[64] apical_trunk_list.append() // 233.67
apical_dendrite[65] apical_trunk_list.append() // 252.71
apical_dendrite[69] apical_trunk_list.append() // 292.06
apical_dendrite[71] apical_trunk_list.append() // 324.53 
apical_dendrite[81] apical_trunk_list.append() // 346.84
apical_dendrite[83] apical_trunk_list.append() // 387.00
apical_dendrite[95] apical_trunk_list.append() // 413.05
apical_dendrite[103] apical_trunk_list.append() // 417.73
apical_dendrite[104] apical_trunk_list.append() // 423.75

/* Make a shape graph with apical trunk sections

objref apical_trunk_list_shape
apical_trunk_list_shape=new Shape()