CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)

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In our experimental study, we combined paired patch-clamp recordings and two-photon Ca2+ imaging to quantify inhibition exerted by individual GABAergic contacts on hippocampal pyramidal cell dendrites. We observed that Ca2+ transients from back-propagating action potentials were significantly reduced during simultaneous activation of individual nearby GABAergic synapses. To simulate dendritic Ca2+ inhibition by individual GABAergic synapses, we employed a multi-compartmental CA1 pyramidal cell model with detailed morphology, voltage-gated channel distributions, and calcium dynamics, based with modifications on the model of Poirazi et al., 2003, modelDB accession # 20212.
1 . Müllner FE, Wierenga CJ, Bonhoeffer T (2015) Precision of Inhibition: Dendritic Inhibition by Individual GABAergic Synapses on Hippocampal Pyramidal Cells Is Confined in Space and Time. Neuron 87:576-89 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Calcium; I Sodium; I Potassium; I h;
Gap Junctions:
Transmitter(s): Gaba;
Simulation Environment: NEURON;
Model Concept(s): Action Potentials; Dendritic Action Potentials; Active Dendrites; Calcium dynamics;
Implementer(s): Muellner, Fiona E [fiona.muellner at];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; I h; I Sodium; I Calcium; I Potassium; Gaba;
apical-non-trunk-list.hoc *
apical-tip-list.hoc *
apical-tip-list-addendum.hoc *
apical-trunk-list.hoc *
axon-sec-list.hoc *
basal-paths.hoc *
basal-tree-list.hoc *
cell.hoc *
cell-analysis.hoc *
n123.hoc *
peri-trunk-list.hoc *
soma-list.hoc *
// This function makes a list with all dendritic sections directly attached to the apical trunk
// written by Terrence Brannon, modified by Yiota Poirazi, July 2001,

objref peri_trunk_list
peri_trunk_list=new SectionList()

apical_dendrite[1] peri_trunk_list.append()
apical_dendrite[5] peri_trunk_list.append()
apical_dendrite[7] peri_trunk_list.append()
apical_dendrite[17] peri_trunk_list.append()
apical_dendrite[24] peri_trunk_list.append()
apical_dendrite[28] peri_trunk_list.append()
apical_dendrite[29] peri_trunk_list.append()
apical_dendrite[30] peri_trunk_list.append()
apical_dendrite[40] peri_trunk_list.append()
apical_dendrite[43] peri_trunk_list.append()
apical_dendrite[47] peri_trunk_list.append()
apical_dendrite[49] peri_trunk_list.append()
apical_dendrite[57] peri_trunk_list.append()
apical_dendrite[59] peri_trunk_list.append()
apical_dendrite[61] peri_trunk_list.append()
apical_dendrite[63] peri_trunk_list.append()
apical_dendrite[66] peri_trunk_list.append()
apical_dendrite[70] peri_trunk_list.append()
apical_dendrite[72] peri_trunk_list.append()
apical_dendrite[96] peri_trunk_list.append()
apical_dendrite[104] peri_trunk_list.append()

objref peri_trunk_addl 
peri_trunk_addl=new SectionList()
apical_dendrite[8]   peri_trunk_addl.append()
apical_dendrite[18]  peri_trunk_addl.append()
apical_dendrite[44]  peri_trunk_addl.append()
apical_dendrite[73]  peri_trunk_addl.append()
apical_dendrite[105] peri_trunk_addl.append()