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Subiculum network model with dynamic chloride/potassium homeostasis (Buchin et al 2016)
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Model Information
Model File
Accession:
206365
This is the code implementing the single neuron and spiking neural network dynamics. The network has the dynamic ion concentrations of extracellular potassium and intracellular chloride. The code contains multiple parameter variations to study various mechanisms of the neural excitability in the context of chloride homeostasis.
Reference:
1 .
Buchin A, Chizhov A, Huberfeld G, Miles R, Gutkin BS (2016) Reduced Efficacy of the KCC2 Cotransporter Promotes Epileptic Oscillations in a Subiculum Network Model.
J Neurosci
36
:11619-11633
[
PubMed
]
Citations
Citation Browser
Model Information
(Click on a link to find other models with that property)
Model Type:
Synapse;
Extracellular;
Dendrite;
Realistic Network;
Glia;
Brain Region(s)/Organism:
Hippocampus;
Cell Type(s):
Hippocampus CA1 pyramidal GLU cell;
Hodgkin-Huxley neuron;
Hippocampus CA1 PV+ fast-firing interneuron;
Channel(s):
KCC2;
I Sodium;
I Potassium;
Na/K pump;
I Calcium;
I Chloride;
I Cl, leak;
I M;
I Na, leak;
I K,leak;
I_HCO3;
I Na,p;
Gap Junctions:
Receptor(s):
NMDA;
AMPA;
GabaA;
Gene(s):
Transmitter(s):
Ions;
Gaba;
Glutamate;
Simulation Environment:
MATLAB;
XPPAUT;
Model Concept(s):
Bursting;
Epilepsy;
Chloride regulation;
Activity Patterns;
Oscillations;
Homeostasis;
Potassium buffering;
Brain Rhythms;
Extracellular Fields;
Implementer(s):
Buchin, Anatoly [anat.buchin at gmail.com];
Search NeuronDB
for information about:
Hippocampus CA1 pyramidal GLU cell
;
GabaA
;
AMPA
;
NMDA
;
I Chloride
;
I Na,p
;
I K,leak
;
I M
;
I Sodium
;
I Calcium
;
I Potassium
;
Na/K pump
;
I Cl, leak
;
I Na, leak
;
KCC2
;
I_HCO3
;
Gaba
;
Glutamate
;
Ions
;
/
BuchinEtAl2016KCC2
.git
hooks
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Optimal synaptic assignment for locomotory behavior in C. elegans (Rakowski & Karbowski 2017)
Optimal synaptic assignment for locomotory behavior in C. elegans (Rakowski & Karbowski 2017)
Optimal synaptic assignment for locomotory behavior in C. elegans (Rakowski & Karbowski 2017)
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Recurrent amplification of grid-cell activity (D'Albis and Kempter 2020)
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Theory and simulation of integrate-and-fire neurons driven by shot noise (Droste & Lindner 2017)
Theory and simulation of integrate-and-fire neurons driven by shot noise (Droste & Lindner 2017)
Theory and simulation of integrate-and-fire neurons driven by shot noise (Droste & Lindner 2017)
Theory and simulation of integrate-and-fire neurons driven by shot noise (Droste & Lindner 2017)
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prepare-commit-msg.sample
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Optimal synaptic assignment for locomotory behavior in C. elegans (Rakowski & Karbowski 2017)
Optimal synaptic assignment for locomotory behavior in C. elegans (Rakowski & Karbowski 2017)
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Rat LGN Thalamocortical Neuron (Connelly et al 2015, 2016)
Recurrent amplification of grid-cell activity (D'Albis and Kempter 2020)
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Theory and simulation of integrate-and-fire neurons driven by shot noise (Droste & Lindner 2017)
Theory and simulation of integrate-and-fire neurons driven by shot noise (Droste & Lindner 2017)
Theory and simulation of integrate-and-fire neurons driven by shot noise (Droste & Lindner 2017)
Theory and simulation of integrate-and-fire neurons driven by shot noise (Droste & Lindner 2017)
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pre-push.sample
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Optimal synaptic assignment for locomotory behavior in C. elegans (Rakowski & Karbowski 2017)
Optimal synaptic assignment for locomotory behavior in C. elegans (Rakowski & Karbowski 2017)
Optimal synaptic assignment for locomotory behavior in C. elegans (Rakowski & Karbowski 2017)
Rat LGN Thalamocortical Neuron (Connelly et al 2015, 2016)
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Optimal synaptic assignment for locomotory behavior in C. elegans (Rakowski & Karbowski 2017)
Optimal synaptic assignment for locomotory behavior in C. elegans (Rakowski & Karbowski 2017)
Optimal synaptic assignment for locomotory behavior in C. elegans (Rakowski & Karbowski 2017)
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update.sample
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Optimal synaptic assignment for locomotory behavior in C. elegans (Rakowski & Karbowski 2017)
Optimal synaptic assignment for locomotory behavior in C. elegans (Rakowski & Karbowski 2017)
Optimal synaptic assignment for locomotory behavior in C. elegans (Rakowski & Karbowski 2017)
Rat LGN Thalamocortical Neuron (Connelly et al 2015, 2016)
Recurrent amplification of grid-cell activity (D'Albis and Kempter 2020)
Striatal Spiny Projection Neuron, inhibition enhances spatial specificity (Dorman et al 2018)
Vibration-sensitive Honeybee interneurons (Ai et al 2017)
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