Subiculum network model with dynamic chloride/potassium homeostasis (Buchin et al 2016)

 Download zip file 
Help downloading and running models
Accession:206365
This is the code implementing the single neuron and spiking neural network dynamics. The network has the dynamic ion concentrations of extracellular potassium and intracellular chloride. The code contains multiple parameter variations to study various mechanisms of the neural excitability in the context of chloride homeostasis.
Reference:
1 . Buchin A, Chizhov A, Huberfeld G, Miles R, Gutkin BS (2016) Reduced Efficacy of the KCC2 Cotransporter Promotes Epileptic Oscillations in a Subiculum Network Model. J Neurosci 36:11619-11633 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Extracellular; Dendrite; Realistic Network; Glia;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell; Hodgkin-Huxley neuron; Hippocampus CA1 PV+ fast-firing interneuron;
Channel(s): KCC2; I Sodium; I Potassium; Na/K pump; I Calcium; I Chloride; I Cl, leak; I M; I Na, leak; I K,leak; I_HCO3; I Na,p;
Gap Junctions:
Receptor(s): NMDA; AMPA; GabaA;
Gene(s):
Transmitter(s): Ions; Gaba; Glutamate;
Simulation Environment: MATLAB; XPPAUT;
Model Concept(s): Bursting; Epilepsy; Chloride regulation; Activity Patterns; Oscillations; Homeostasis; Potassium buffering; Brain Rhythms; Extracellular Fields;
Implementer(s): Buchin, Anatoly [anat.buchin at gmail.com];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; GabaA; AMPA; NMDA; I Chloride; I Na,p; I K,leak; I M; I Sodium; I Calcium; I Potassium; Na/K pump; I Cl, leak; I Na, leak; KCC2; I_HCO3; Gaba; Glutamate; Ions;
/
BuchinEtAl2016KCC2
.git
hooks
applypatch-msg.sample *
commit-msg.sample *
post-update.sample *
pre-applypatch.sample *
pre-commit.sample *
prepare-commit-msg.sample *
pre-push.sample *
pre-rebase.sample *
update.sample *
                            
#!/bin/sh
#
# An example hook script to check the commit log message taken by
# applypatch from an e-mail message.
#
# The hook should exit with non-zero status after issuing an
# appropriate message if it wants to stop the commit.  The hook is
# allowed to edit the commit message file.
#
# To enable this hook, rename this file to "applypatch-msg".

. git-sh-setup
commitmsg="$(git rev-parse --git-path hooks/commit-msg)"
test -x "$commitmsg" && exec "$commitmsg" ${1+"$@"}
: