Subiculum network model with dynamic chloride/potassium homeostasis (Buchin et al 2016)

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Accession:206365
This is the code implementing the single neuron and spiking neural network dynamics. The network has the dynamic ion concentrations of extracellular potassium and intracellular chloride. The code contains multiple parameter variations to study various mechanisms of the neural excitability in the context of chloride homeostasis.
Reference:
1 . Buchin A, Chizhov A, Huberfeld G, Miles R, Gutkin BS (2016) Reduced Efficacy of the KCC2 Cotransporter Promotes Epileptic Oscillations in a Subiculum Network Model. J Neurosci 36:11619-11633 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Extracellular; Dendrite; Realistic Network; Glia;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell; Hodgkin-Huxley neuron; Hippocampus CA1 PV+ fast-firing interneuron;
Channel(s): KCC2; I Sodium; I Potassium; Na/K pump; I Calcium; I Chloride; I Cl, leak; I M; I Na, leak; I K,leak; I_HCO3; I Na,p;
Gap Junctions:
Receptor(s): NMDA; AMPA; GabaA;
Gene(s):
Transmitter(s): Ions; Gaba; Glutamate;
Simulation Environment: MATLAB; XPPAUT;
Model Concept(s): Bursting; Epilepsy; Chloride regulation; Activity Patterns; Oscillations; Homeostasis; Potassium buffering; Brain Rhythms; Extracellular Fields;
Implementer(s): Buchin, Anatoly [anat.buchin at gmail.com];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; GabaA; AMPA; NMDA; I Chloride; I Na,p; I K,leak; I M; I Sodium; I Calcium; I Potassium; Na/K pump; I Cl, leak; I Na, leak; KCC2; I_HCO3; Gaba; Glutamate; Ions;
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BuchinEtAl2016KCC2
.git
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applypatch-msg.sample *
commit-msg.sample *
post-update.sample *
pre-applypatch.sample *
pre-commit.sample *
prepare-commit-msg.sample *
pre-push.sample *
pre-rebase.sample *
update.sample *
                            
#!/bin/sh
#
# An example hook script to check the commit log message.
# Called by "git commit" with one argument, the name of the file
# that has the commit message.  The hook should exit with non-zero
# status after issuing an appropriate message if it wants to stop the
# commit.  The hook is allowed to edit the commit message file.
#
# To enable this hook, rename this file to "commit-msg".

# Uncomment the below to add a Signed-off-by line to the message.
# Doing this in a hook is a bad idea in general, but the prepare-commit-msg
# hook is more suited to it.
#
# SOB=$(git var GIT_AUTHOR_IDENT | sed -n 's/^\(.*>\).*$/Signed-off-by: \1/p')
# grep -qs "^$SOB" "$1" || echo "$SOB" >> "$1"

# This example catches duplicate Signed-off-by lines.

test "" = "$(grep '^Signed-off-by: ' "$1" |
	 sort | uniq -c | sed -e '/^[ 	]*1[ 	]/d')" || {
	echo >&2 Duplicate Signed-off-by lines.
	exit 1
}