Mechanisms of fast rhythmic bursting in a layer 2/3 cortical neuron (Traub et al 2003)

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Accession:20756
This simulation is based on the reference paper listed below. This port was made by Roger D Traub and Maciej T Lazarewicz (mlazarew at seas.upenn.edu) Thanks to Ashlen P Reid for help with porting a morphology of the cell.
Reference:
1 . Traub RD, Buhl EH, Gloveli T, Whittington MA (2003) Fast rhythmic bursting can be induced in layer 2/3 cortical neurons by enhancing persistent Na+ conductance or by blocking BK channels. J Neurophysiol 89:909-21 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex L2/3 pyramidal GLU cell;
Channel(s): I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I h; I K,Ca; I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Bursting; Active Dendrites; Detailed Neuronal Models; Axonal Action Potentials; Calcium dynamics;
Implementer(s): Lazarewicz, Maciej [mlazarew at gmu.edu]; Traub, Roger D [rtraub at us.ibm.com];
Search NeuronDB for information about:  Neocortex L2/3 pyramidal GLU cell; I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I h; I K,Ca; I Sodium; I Calcium; I Potassium; 
This port was made from the FORTRAN code into the NEURON enviroment based on 

	Traub RD, Buhl EH, Gloveli T, Whittington MA. 
	Fast Rhythmic Bursting Can Be Induced in Layer 2/3 Cortical Neurons by 
	Enhancing Persistent Na(+) Conductance or by Blocking BK Channels.
	J Neurophysiol. 2003 Feb; 89(2):909-21

This port was made by Roger D Traub and Maciej Lazarewicz (mlazarew@seas.upenn.edu)

Thanks to Ashlen P Reid for help with porting a morphology of the cell.

This port is reproducing figures 2, 4, 5, 6 and 7.

Under unix systems:
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to compile the mod files use the command

 nrnivmod

and run the simulation hoc file with the command

 nrngui pyr3.hoc


Under Windows systems:
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to compile the mod files use the "mknrndll" command.
A double click on the simulation file

 pyr3.hoc

will open the simulation window.

Questions on how to use this port should be directed to mlazarew@seas.upenn.edu