MicrocircuitDB: Distance-dependent synaptic strength in CA1 pyramidal neurons (Menon et al. 2013)

Distance-dependent synaptic strength in CA1 pyramidal neurons (Menon et al. 2013)

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Accession:222726

Menon et al. (2013) describes the experimentally-observed variation in synaptic AMPA and NMDA conductance as a function of distance from the soma. This model explores the effect of this variation on somatic EPSPs and dendritic spike initiation, as compared to the case of uniform AMPA and NMDA conductance.
Reference:
1 . Menon V, Musial TF, Liu A, Katz Y, Kath WL, Spruston N, Nicholson DA (2013) Balanced synaptic impact via distance-dependent synapse distribution and complementary expression of AMPARs and NMDARs in hippocampal dendrites. Neuron 80:1451-63 [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell; Synapse;
Brain Region(s)/Organism:	Hippocampus;
Cell Type(s):	Hippocampus CA1 pyramidal GLU cell;
Channel(s):	I A; I K; I Na, slow inactivation;
Gap Junctions:
Receptor(s):	AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment:	NEURON;
Model Concept(s):	Synaptic Integration;
Implementer(s):	Menon, Vilas [vilasmenon2008 at u dot northwestern dot edu];