/*--------------------------------------------------------------
TEMPLATE FILE FOR LTS CORTICAL PYRAMIDAL CELL
---------------------------------------------
One compartment model and currents derived from:
Pospischil, M., Toledo-Rodriguez, M., Monier, C., Piwkowska, Z.,
Bal, T., Fregnac, Y., Markram, H. and Destexhe, A.
Minimal Hodgkin-Huxley type models for different classes of
cortical and thalamic neurons.
Biological Cybernetics 99: 427-441, 2008.
Model taken from:
Destexhe, A. Contreras, D. and Steriade, M. LTS cells in cerebral
cortex and their role in generating spike-and-wave oscillations.
Neurocomputing 38: 555-563 (2001).
- one compartment model
- passive
- HH Traub
- IM
- T-type calcium current
Alain Destexhe, CNRS, 2008
--------------------------------------------------------------*/
print " "
print " << defining template for one-compartment sPYr cell >> "
print " "
begintemplate sPYr // create a new template object
public soma
create soma[1]
proc init() { local v_potassium, v_sodium
v_potassium = -100 // potassium reversal potential
v_sodium = 50 // sodium reversal potential
soma {
Ra = 100 // geometry
nseg = 1
diam = 96
L = 96 // so that area is about 29000 um2
cm = 1
insert pas // leak current
e_pas = -70
g_pas = 1e-5 // idem TC cell
// conversion with McC units:
// g(S/cm2) = g(nS)*1e-9/29000e-8
// = g(nS) * 3.45e-6
insert hh2 // Hodgin-Huxley INa and IK
ek = v_potassium
ena = v_sodium
vtraub_hh2 = -55 // Resting Vm, BJ was -55
gnabar_hh2 = 0.05 // McCormick=15 muS, thal was 0.09
gkbar_hh2 = 0.005 // spike duration of pyr cells
insert im // M current
taumax_im = 1000
gkbar_im = 3e-5 // specific to LTS pyr cell
insert cad // calcium decay
depth_cad = 1 // McCormick= 0.1 um
taur_cad = 5 // McCormick=1 ms !!!
cainf_cad = 2.4e-4 // McCormick=0
kt_cad = 0 // no pump
insert it // IT current
cai = 2.4e-4
cao = 2
eca = 120
gcabar_it = 0.001 // specific to LTS pyr cell
}
print " "
print "<< sPYr: passive, INa, IK, Ca++, IT inserted >>"
print " "
}
endtemplate sPYr
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