MicrocircuitDB: Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)

Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)

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Model Information
Model File

Accession:223955

Model of pyramidal neurons that either hyper or hypo excitable due to SCN2A mutations. Mutations are taken from patients with ASD or Epilepsy
Reference:
1 . Ben-Shalom R, Keeshen CM, Berrios KN, An JY, Sanders SJ, Bender KJ (2017) Opposing Effects on NaV1.2 Function Underlie Differences Between SCN2A Variants Observed in Individuals With Autism Spectrum Disorder or Infantile Seizures. Biol Psychiatry 82:224-232 [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):	Neocortex L5/6 pyramidal GLU cell;
Channel(s):	I Na,t; I Sodium; I K;
Gap Junctions:
Receptor(s):
Gene(s):	Nav1.2 SCN2A;
Transmitter(s):
Simulation Environment:	NEURON; MATLAB;
Model Concept(s):	Epilepsy; Autism spectrum disorder;
Implementer(s):	Ben-Shalom, Roy [rbenshalom at ucdavis.edu];