// genesis
/*********************************************************************
** The current equations themselves
*********************************************************************/
float offset = 0.01
function make_Granule_KA
int i, cdivs
float zinf, ztau, c, dc, cmin, cmax
float x, dx, y
float a, b
/* The folowing variables are temporary (not temperature) variables
used to speed up computations */
float mintau
float max
float tau
float temp1
float temp2
/* K A-current fast transient potassium channel, following Bardoni and Belluzzi 1993 */
create tabchannel Gran_KA
setfield Gran_KA Ek {EK} Gbar 3.67 Ik 0 Gk 0 Xpower 3 Ypower 1 \
Zpower 0
call Gran_KA TABCREATE X {tab_xdivs} {tab_xmin} {tab_xmax}
x = {tab_xmin} - {offset}
dx = ({tab_xmax} - {tab_xmin})/{tab_xdivs}
openfile KA_a_max.test w
openfile KA_a_tau.test w
for (i = 0; i <= ({tab_xdivs}); i = i + 1)
tau = 0.410 * ({exp {(- (x * 1e3 + 43.5) / 42.8)}}) + 0.167
max = 1 / (1 + {exp {((-46.7 - x * 1e3) / 19.8)}})
setfield Gran_KA X_A->table[{i}] {tau * 0.001} // 0.005}
setfield Gran_KA X_B->table[{i}] {max}
writefile KA_a_max.test {x} {getfield Gran_KA X_B->table[{i}]}
writefile KA_a_tau.test {x} {getfield Gran_KA X_A->table[{i}]}
x = x + dx
end
tweaktau Gran_KA X
setfield Gran_KA X_A->calc_mode 1 X_B->calc_mode 1
closefile KA_a_max.test
closefile KA_a_tau.test
call Gran_KA TABCREATE Y {tab_xdivs} {tab_xmin} {tab_xmax}
x = {tab_xmin} - {offset}
openfile KA_i_max.test w
openfile KA_i_tau.test w
for (i = 0; i <= ({tab_xdivs}); i = i + 1)
tau = 10.8 + 30 * x + \
1 / (57.9 * {exp {x * 127}} + 134e-6 * {exp {- x * 59}})
max = 1 / (1 + {exp {((x * 1e3 + 78.8) / 8.4)}})
setfield Gran_KA Y_A->table[{i}] {tau * 0.001} // 0.0002} // correction for sec and for 37 deg C
setfield Gran_KA Y_B->table[{i}] {max}
writefile KA_i_max.test {x} {getfield Gran_KA Y_B->table[{i}]}
writefile KA_i_tau.test {x} {getfield Gran_KA Y_A->table[{i}]}
x = x + dx
end
tweaktau Gran_KA Y
setfield Gran_KA Y_A->calc_mode 1 Y_B->calc_mode 1
closefile KA_i_max.test
closefile KA_i_tau.test
// call Gran_KA TABSAVE tabKA37.data
end
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