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A detailed Purkinje cell model (Masoli et al 2015)
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Model Information
Model File
Accession:
229585
The Purkinje cell is one of the most complex type of neuron in the central nervous system and is well known for its massive dendritic tree. The initiation of the action potential was theorized to be due to the high calcium channels presence in the dendritic tree but, in the last years, this idea was revised. In fact, the Axon Initial Segment, the first section of the axon was seen to be critical for the spontaneous generation of action potentials. The model reproduces the behaviours linked to the presence of this fundamental sections and the interplay with the other parts of the neuron.
Reference:
1 .
Masoli S, Solinas S, D'Angelo E (2015) Action potential processing in a detailed Purkinje cell model reveals a critical role for axonal compartmentalization.
Front Cell Neurosci
9
:47
[
PubMed
]
Citations
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Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Axon;
Brain Region(s)/Organism:
Cerebellum;
Cell Type(s):
Cerebellum Purkinje GABA cell;
Channel(s):
I Sodium;
I Calcium;
I Na,t;
I K;
Gap Junctions:
Receptor(s):
Gene(s):
Cav2.1 CACNA1A;
Cav3.1 CACNA1G;
Cav3.2 CACNA1H;
Cav3.3 CACNA1I;
Nav1.6 SCN8A;
Kv1.1 KCNA1;
Kv1.5 KCNA5;
Kv3.3 KCNC3;
Kv3.4 KCNC4;
Kv4.3 KCND3;
KCa1.1 KCNMA1;
KCa2.2 KCNN2;
KCa3.1 KCNN4;
Kir2.1 KCNJ2;
HCN1;
Transmitter(s):
Simulation Environment:
NEURON;
Python;
Model Concept(s):
Bursting;
Detailed Neuronal Models;
Action Potentials;
Action Potential Initiation;
Axonal Action Potentials;
Implementer(s):
Masoli, Stefano [stefano.masoli at unipv.it];
Solinas, Sergio [solinas at unipv.it];
Search NeuronDB
for information about:
Cerebellum Purkinje GABA cell
;
I Na,t
;
I K
;
I Sodium
;
I Calcium
;
/
purkinjecell
mod_files
Cav2_1.mod
*
Other models using Cav2_1.mod:
Purkinje cell: Synaptic activation predicts voltage control of burst-pause (Masoli & D'Angelo 2017)
Cav3_1.mod
*
Other models using Cav3_1.mod:
Purkinje cell: Synaptic activation predicts voltage control of burst-pause (Masoli & D'Angelo 2017)
Cav3_2.mod
*
Other models using Cav3_2.mod:
Purkinje cell: Synaptic activation predicts voltage control of burst-pause (Masoli & D'Angelo 2017)
Cav3_3.mod
*
Other models using Cav3_3.mod:
Purkinje cell: Synaptic activation predicts voltage control of burst-pause (Masoli & D'Angelo 2017)
cdp5.mod
*
Other models using cdp5.mod:
Purkinje cell: Synaptic activation predicts voltage control of burst-pause (Masoli & D'Angelo 2017)
HCN1_Angeloetal2007.mod
*
Other models using HCN1_Angeloetal2007.mod:
Purkinje cell: Synaptic activation predicts voltage control of burst-pause (Masoli & D'Angelo 2017)
Kca11.mod
*
Other models using Kca11.mod:
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Purkinje cell: Synaptic activation predicts voltage control of burst-pause (Masoli & D'Angelo 2017)
Kca22.mod
*
Other models using Kca22.mod:
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Purkinje cell: Synaptic activation predicts voltage control of burst-pause (Masoli & D'Angelo 2017)
Kca31.mod
*
Other models using Kca31.mod:
Purkinje cell: Synaptic activation predicts voltage control of burst-pause (Masoli & D'Angelo 2017)
Kir23.mod
*
Other models using Kir23.mod:
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Purkinje cell: Synaptic activation predicts voltage control of burst-pause (Masoli & D'Angelo 2017)
Kv11.mod
*
Other models using Kv11.mod:
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Purkinje cell: Synaptic activation predicts voltage control of burst-pause (Masoli & D'Angelo 2017)
Kv15.mod
*
Other models using Kv15.mod:
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Purkinje cell: Synaptic activation predicts voltage control of burst-pause (Masoli & D'Angelo 2017)
Kv33.mod
*
Other models using Kv33.mod:
Purkinje cell: Synaptic activation predicts voltage control of burst-pause (Masoli & D'Angelo 2017)
Kv34.mod
*
Other models using Kv34.mod:
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Purkinje cell: Synaptic activation predicts voltage control of burst-pause (Masoli & D'Angelo 2017)
Kv43.mod
*
Other models using Kv43.mod:
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Purkinje cell: Synaptic activation predicts voltage control of burst-pause (Masoli & D'Angelo 2017)
Leak.mod
*
Other models using Leak.mod:
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Purkinje cell: Synaptic activation predicts voltage control of burst-pause (Masoli & D'Angelo 2017)
Nav16.mod
*
Other models using Nav16.mod:
Purkinje cell: Synaptic activation predicts voltage control of burst-pause (Masoli & D'Angelo 2017)
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