Specific inhibition of dendritic plateau potential in striatal projection neurons (Du et al 2017)

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Accession:231416
We explored dendritic plateau potentials in a biophysically detailed SPN model. We coupled the dendritic plateaus to different types of inhibitions (dendritic fast and slow inhibitions, perisomatic inhibition from FS interneurons , etc.) We found the inhibition provides precise control over the plateau potential, and thus the spiking output of SPNs.
Reference:
1 . Du K, Wu YW, Lindroos R, Liu Y, Rózsa B, Katona G, Ding JB, Kotaleski JH (2017) Cell-type-specific inhibition of the dendritic plateau potential in striatal spiny projection neurons. Proc Natl Acad Sci U S A 114:E7612-E7621 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Dendrite; Channel/Receptor;
Brain Region(s)/Organism: Striatum;
Cell Type(s): Neostriatum spiny neuron;
Channel(s): I A; I A, slow; Kir; I Calcium; I K,Ca; I L high threshold; I Na,p; I Na,t; I Q; I R; I K;
Gap Junctions:
Receptor(s): AMPA; GabaA; NMDA;
Gene(s): Cav3.2 CACNA1H;
Transmitter(s): Glutamate; Gaba;
Simulation Environment: GENESIS;
Model Concept(s):
Implementer(s): Du, Kai [kai.du at ki.se];
Search NeuronDB for information about:  GabaA; AMPA; NMDA; I Na,p; I Na,t; I L high threshold; I A; I K; I K,Ca; I Calcium; I A, slow; I R; I Q; Kir; Gaba; Glutamate;
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MSN
MScell
channels
.directory
.goutputstream-A48NIW
.goutputstream-JLG4IW
ampa_channel.g *
BKKchannel.g
CaL12inact_channel.g
CaL13_channel.g
CaNinact_channel.g
CaR_channel.g
CaT_channel.g
gaba_channel.g
K_DR_channel.g
kAf_chanRE.g
kAs_chanKD.g
kAs_chanRE.g
kIR_chanKD.g
naF_chanOg.g
NaP_channel.g
nmda_channel.g *
SKchannelCaDep.g *
synaptic_channel.g *
tabchanforms.g *
                            
//genesis


function make_BKK_channel
    float EK=-0.09  // V
  //  int xdivs = 299
    int xdivs = 299
    int ydivs = {xdivs}
    float xmin, xmax, ymin, ymax
    xmin = -0.1; xmax = 0.05; ymin = 0.0; ymax = 0.005 // x = Vm, y = [Ca],mM
    int i, j
    float x, dx, y, dy, a, b
    float Temp = 35
    float ZFbyRT = 23210/(273.15 + Temp)
    if (!({exists BKK_channel}))
        create tab2Dchannel BKK_channel
        setfield BKK_channel Ek {EK} Gbar 0.0  \
            Xindex {VOLT_C1_INDEX} Xpower 1 Ypower 0 Zpower 0
        call BKK_channel TABCREATE X {xdivs} {xmin} {xmax} \
            {ydivs} {ymin} {ymax}
    end
    dx = (xmax - xmin)/xdivs
    dy = (ymax - ymin)/ydivs
    x = xmin
    for (i = 0; i <= xdivs; i = i + 1)
        y = ymin
        for (j = 0; j <= ydivs; j = j + 1)
            a = 480*y/(y + 0.180*{exp {-0.84*ZFbyRT*x}})
            b = 280/(1 + y/(0.011*{exp {-1.00*ZFbyRT*x}}))
            setfield BKK_channel X_A->table[{i}][{j}] {a}
            setfield BKK_channel X_B->table[{i}][{j}] {a + b}
            y = y + dy
        end
        x = x + dx
    end
    setfield BKK_channel X_A->calc_mode {LIN_INTERP}
    setfield BKK_channel X_B->calc_mode {LIN_INTERP}

end