//genesis
//gaba_channel.g
function make_GABA_channel
str chanpath = "GABA_channel"
// From Galarreta and Hestrin 1997 (used in Wolfs model)
float tau1 = 0.25e-3 //
float tau2 = 3.75e-3 //
float gmax = 750e-12 //Modified Koos 2004 (Wolf uses 435e-12)
echo "XXXXXXXXXXXXXXX make_GABA_channel XXXXXXXXXXXXXXXX"
echo "XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX"
echo "XXXXXXXXXXXXXXX make_GABA_channel XXXXXXXXXXXXXXXX"
create synchan {chanpath}
setfield {chanpath} tau1 {tau1} \
tau2 {tau2}\
gmax {gmax}\
Ek {Egaba}
end
function make_GABA2_channel
//"A Novel Functionally Distinct Subtype of Striatal Neuropeptide Y Interneuron", Tepper 2011, J. Neurosci.
// slow GABAA inhibition from NPY-NGF to MSN
str chanpath = "NPY_NGF_GABA_channel"
float tau1 = 10e-3
float tau2 = 80e-3 //150
float gmax = 900e-12 //
echo "XXXXXXXXXXXXXXX make_GABA2_channel XXXXXXXXXXXXXXXX"
echo "XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX"
echo "XXXXXXXXXXXXXXX make_GABA2_channel XXXXXXXXXXXXXXXX"
create synchan {chanpath}
setfield {chanpath} tau1 {tau1} \
tau2 {tau2}\
gmax {gmax}\
Ek {Egaba}
end
function make_GABA3_channel
//"Recurrent Collateral Connections of Striatal Medium Spiny Neurons Are Disrupted in Models of Parkinson’s Disease"
//Stefano Taverna, et.al. 2008 J.Neurosci.
str chanpath = "MSN_GABA_channel"
float tau1 = 1e-3
float tau2 = 10e-3 // fig2.
float gmax = 700e-12 //
echo "XXXXXXXXXXXXXXX make_GABA3_channel XXXXXXXXXXXXXXXX"
echo "XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX"
echo "XXXXXXXXXXXXXXX make_GABA3_channel XXXXXXXXXXXXXXXX"
create synchan {chanpath}
setfield {chanpath} tau1 {tau1} \
tau2 {tau2}\
gmax {gmax}\
Ek {Egaba}
end
// the pseudoGABA has a fixed driving force of 20 mV ( Ek - V )
// by default, "synchan" set voltage "V" = 0
// Note we DO NOT make the pseudoGABA communicate with its parent compartment
function make_pseudoGABA_channel(tau1,tau2,Ek_pseudoGABA)
str chanpath = "pseudoGABA_channel"
float tau1
float tau2
float Ek_pesudoGABA
float gmax = 700e-12 //
echo "XXXXXXXXXXXXXXX make_pseudoGABA_channel XXXXXXXXXXXXXXXX"
echo "XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX"
echo "XXXXXXXXXXXXXXX make_pseudoGABA_channel XXXXXXXXXXXXXXXX"
create synchan {chanpath}
setfield {chanpath} tau1 {tau1} \
tau2 {tau2}\
gmax {gmax}\
Ek {Ek_pseudoGABA}
end
//an AMPA like channel
function make_AMPA2_channel
str chanpath = "AMPA2_channel"
// From Galarreta and Hestrin 1997 (used in Wolfs model)
float tau1 = 1.9e-3
float tau2 = 4.8e-3
float gmax = 750e-12 //Modified Koos 2004 (Wolf uses 435e-12)
create synchan {chanpath}
setfield {chanpath} tau1 {tau1} \
tau2 {tau2}\
gmax {gmax}\
Ek 0
end
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