Specific inhibition of dendritic plateau potential in striatal projection neurons (Du et al 2017)

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Accession:231416
We explored dendritic plateau potentials in a biophysically detailed SPN model. We coupled the dendritic plateaus to different types of inhibitions (dendritic fast and slow inhibitions, perisomatic inhibition from FS interneurons , etc.) We found the inhibition provides precise control over the plateau potential, and thus the spiking output of SPNs.
Reference:
1 . Du K, Wu YW, Lindroos R, Liu Y, Rózsa B, Katona G, Ding JB, Kotaleski JH (2017) Cell-type-specific inhibition of the dendritic plateau potential in striatal spiny projection neurons. Proc Natl Acad Sci U S A 114:E7612-E7621 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Dendrite; Channel/Receptor;
Brain Region(s)/Organism: Striatum;
Cell Type(s): Neostriatum spiny neuron;
Channel(s): I A; I A, slow; Kir; I Calcium; I K,Ca; I L high threshold; I Na,p; I Na,t; I Q; I R; I K;
Gap Junctions:
Receptor(s): AMPA; GabaA; NMDA;
Gene(s): Cav3.2 CACNA1H;
Transmitter(s): Glutamate; Gaba;
Simulation Environment: GENESIS;
Model Concept(s):
Implementer(s): Du, Kai [kai.du at ki.se];
Search NeuronDB for information about:  GabaA; AMPA; NMDA; I Na,p; I Na,t; I L high threshold; I A; I K; I K,Ca; I Calcium; I A, slow; I R; I Q; Kir; Gaba; Glutamate;
%close all
 clear all
 
 KAsX=load('KAsXtable.txt');
 KAsY=load('KAsYtable.txt');
%  kafX=load('kaFXtable.txt');
%  kafY=load('kaFYtable.txt');

 
 
 KAsXA=KAsX(:,1);
 KAsXB=KAsX(:,2);
 KAsYA=KAsY(:,1);
 KAsYB=KAsY(:,2);
%  kafXA=kafX(:,1);
%  kafXB=kafX(:,2);
%  kafYA=kafY(:,1);
%  kafYB=kafY(:,2); 
 
 n =length(KAsXA(:))
 dv = 150/3000; %(mV)
 n=(-100:dv:50);
 
 figure(1)
hold on
 subplot(2,2,1)
 plot(n,KAsXA,'b--')
 title('mtau of KAs')
 hold on

 subplot(2,2,2)
 plot(n,KAsXB,'r--')
 title('minf of KAs')
 hold on
 
 subplot(2,2,3)
  plot(n,KAsYA,'b--')
 title('htau of KAs')
 hold on
 
 subplot(2,2,4)
  plot(n,KAsYB,'r--')
 title('hinf of KAs')
 hold on
%   subplot(2,2,5)
%  plot(n,kafXA,'b--')
%  title('mtau of kaf')
 
%  subplot(2,2,6)
%  plot(n,kafXB,'r--')
%  title('minf of kaf')
% 
%  subplot(2,2,7)
%   plot(n,kafYA,'b--')
%  title('htau of kaf')
% 
%  subplot(2,2,8)
%   plot(n,kafYB,'r--')
%  title('hinf of kaf')