Find models by
Find models for
Find models of
Knox implementation of Destexhe 1998 spike and wave oscillation model (Knox et al 2018)
Download zip file
Help downloading and running models
" ...The aim of this study was to use an established thalamocortical computer model to determine how T-type calcium channels work in concert with cortical excitability to contribute to pathogenesis and treatment response in CAE. METHODS: The model is comprised of cortical pyramidal, cortical inhibitory, thalamocortical relay, and thalamic reticular single-compartment neurons, implemented with Hodgkin-Huxley model ion channels and connected by AMPA, GABAA , and GABAB synapses. Network behavior was simulated for different combinations of T-type calcium channel conductance, inactivation time, steady state activation/inactivation shift, and cortical GABAA conductance. RESULTS: Decreasing cortical GABAA conductance and increasing T-type calcium channel conductance converted spindle to spike and wave oscillations; smaller changes were required if both were changed in concert. In contrast, left shift of steady state voltage activation/inactivation did not lead to spike and wave oscillations, whereas right shift reduced network propensity for oscillations of any type...."
Knox AT, Glauser T, Tenney J, Lytton WW, Holland K (2018) Modeling pathogenesis and treatment response in childhood absence epilepsy.
(Click on a link to find other models with that property)
Thalamus reticular nucleus GABA cell;
Thalamus geniculate nucleus/lateral principal GLU cell;
Neocortex layer 4 pyramidal cell;
Neocortex fast spiking (FS) interneuron;
I T low threshold;
Knox, Andrew [knox at neurology.wisc.edu];
Destexhe, Alain [Destexhe at iaf.cnrs-gif.fr];
for information about:
Thalamus geniculate nucleus/lateral principal GLU cell
Thalamus reticular nucleus GABA cell
I T low threshold
File not selected
<- Select file from this column.