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Knox implementation of Destexhe 1998 spike and wave oscillation model (Knox et al 2018)
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Model Information
Model File
Accession:
234233
" ...The aim of this study was to use an established thalamocortical computer model to determine how T-type calcium channels work in concert with cortical excitability to contribute to pathogenesis and treatment response in CAE. METHODS: The model is comprised of cortical pyramidal, cortical inhibitory, thalamocortical relay, and thalamic reticular single-compartment neurons, implemented with Hodgkin-Huxley model ion channels and connected by AMPA, GABAA , and GABAB synapses. Network behavior was simulated for different combinations of T-type calcium channel conductance, inactivation time, steady state activation/inactivation shift, and cortical GABAA conductance. RESULTS: Decreasing cortical GABAA conductance and increasing T-type calcium channel conductance converted spindle to spike and wave oscillations; smaller changes were required if both were changed in concert. In contrast, left shift of steady state voltage activation/inactivation did not lead to spike and wave oscillations, whereas right shift reduced network propensity for oscillations of any type...."
Reference:
1 .
Knox AT, Glauser T, Tenney J, Lytton WW, Holland K (2018) Modeling pathogenesis and treatment response in childhood absence epilepsy.
Epilepsia
59
:135-145
[
PubMed
]
Citations
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Model Information
(Click on a link to find other models with that property)
Model Type:
Realistic Network;
Brain Region(s)/Organism:
Neocortex;
Thalamus;
Cell Type(s):
Thalamus reticular nucleus GABA cell;
Thalamus geniculate nucleus/lateral principal GLU cell;
Hodgkin-Huxley neuron;
Neocortex layer 4 pyramidal cell;
Neocortex fast spiking (FS) interneuron;
Channel(s):
I h;
I Na,t;
I K,leak;
I T low threshold;
I M;
Gap Junctions:
Receptor(s):
GabaA;
GabaB;
AMPA;
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Spindles;
Oscillations;
Implementer(s):
Knox, Andrew [knox at neurology.wisc.edu];
Destexhe, Alain [Destexhe at iaf.cnrs-gif.fr];
Search NeuronDB
for information about:
Thalamus geniculate nucleus/lateral principal GLU cell
;
Thalamus reticular nucleus GABA cell
;
GabaA
;
GabaB
;
AMPA
;
I Na,t
;
I T low threshold
;
I K,leak
;
I M
;
I h
;
Download the displayed file
/
KnoxEtAl2017
README.html
README_.txt
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screenshot1.png
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load_file("nrngui.hoc") load_file("rundemo.hoc")
