Advanced search
User account
Login
Register
Find models by
Model name
First author
Each author
Find models for
Brain region
Concept
Find models of
Realistic Microcircuits
Connectionist Networks
The origin of different spike and wave-like events (Hall et al 2017)
Download zip file
Help downloading and running models
Model Information
Model File
Accession:
235561
Acute In vitro models have revealed a great deal of information about mechanisms underlying many types of epileptiform activity. However, few examples exist that shed light on spike and wave (SpW) patterns of pathological activity. SpW are seen in many epilepsy syndromes, both generalised and focal, and manifest across the entire age spectrum. They are heterogeneous in terms of their severity, symptom burden and apparent anatomical origin (thalamic, neocortical or both), but any relationship between this heterogeneity and underlying pathology remains elusive. Here we demonstrate that physiological delta frequency rhythms act as an effective substrate to permit modelling of SpW of cortical origin and may help to address this issue. ..."
Reference:
1 .
Hall SP, Traub RD, Adams NE, Cunningham MO, Schofield I, Jenkins AJ, Whittington MA (2018) Enhanced interlaminar excitation or reduced superficial layer inhibition in neocortex generates different spike-and-wave-like electrographic events in vitro.
J Neurophysiol
119
:49-61
[
PubMed
]
Citations
Citation Browser
Model Information
(Click on a link to find other models with that property)
Model Type:
Realistic Network;
Brain Region(s)/Organism:
Neocortex;
Thalamus;
Cell Type(s):
Thalamus geniculate nucleus/lateral principal GLU cell;
Thalamus reticular nucleus GABA cell;
Neocortex U1 L6 pyramidal corticalthalamic GLU cell;
Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell;
Neocortex fast spiking (FS) interneuron;
Neocortex spiking regular (RS) neuron;
Neocortex spiking low threshold (LTS) neuron;
Channel(s):
I Na,p;
I Na,t;
I L high threshold;
I T low threshold;
I A;
I K;
I M;
I h;
I K,Ca;
I Calcium;
I A, slow;
Gap Junctions:
Gap junctions;
Receptor(s):
GabaA;
AMPA;
NMDA;
Gene(s):
Transmitter(s):
Simulation Environment:
FORTRAN;
Model Concept(s):
Epilepsy;
Implementer(s):
Traub, Roger D [rtraub at us.ibm.com];
Search NeuronDB
for information about:
Thalamus geniculate nucleus/lateral principal GLU cell
;
Thalamus reticular nucleus GABA cell
;
Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell
;
Neocortex U1 L6 pyramidal corticalthalamic GLU cell
;
GabaA
;
AMPA
;
NMDA
;
I Na,p
;
I Na,t
;
I L high threshold
;
I T low threshold
;
I A
;
I K
;
I M
;
I h
;
I K,Ca
;
I Calcium
;
I A, slow
;
/
HallEtAl2017
readme.txt
dexptablebig_setup.f
*
Other models using dexptablebig_setup.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
Unbalanced peptidergic inhibition in superficial cortex underlies seizure activity (Hall et al 2015)
dexptablesmall_setup.f
*
Other models using dexptablesmall_setup.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
Unbalanced peptidergic inhibition in superficial cortex underlies seizure activity (Hall et al 2015)
fnmda.f
*
Other models using fnmda.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
Unbalanced peptidergic inhibition in superficial cortex underlies seizure activity (Hall et al 2015)
groucho_gapbld.f
*
Other models using groucho_gapbld.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
Unbalanced peptidergic inhibition in superficial cortex underlies seizure activity (Hall et al 2015)
groucho_gapbld_mix.f
*
Other models using groucho_gapbld_mix.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
Unbalanced peptidergic inhibition in superficial cortex underlies seizure activity (Hall et al 2015)
integrate_deepaxaxx.f
*
Other models using integrate_deepaxaxx.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
Unbalanced peptidergic inhibition in superficial cortex underlies seizure activity (Hall et al 2015)
integrate_deepbaskx.f
*
Other models using integrate_deepbaskx.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
Unbalanced peptidergic inhibition in superficial cortex underlies seizure activity (Hall et al 2015)
integrate_deepLTSx.f
*
Other models using integrate_deepLTSx.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
Unbalanced peptidergic inhibition in superficial cortex underlies seizure activity (Hall et al 2015)
integrate_deepng.f
*
Other models using integrate_deepng.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
Unbalanced peptidergic inhibition in superficial cortex underlies seizure activity (Hall et al 2015)
integrate_nontuftRSXXB.f
*
Other models using integrate_nontuftRSXXB.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
Unbalanced peptidergic inhibition in superficial cortex underlies seizure activity (Hall et al 2015)
integrate_nrtxB.f
*
Other models using integrate_nrtxB.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
Unbalanced peptidergic inhibition in superficial cortex underlies seizure activity (Hall et al 2015)
integrate_spinstelldiegoxB.f
*
Other models using integrate_spinstelldiegoxB.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
Unbalanced peptidergic inhibition in superficial cortex underlies seizure activity (Hall et al 2015)
integrate_supaxaxx.f
*
Other models using integrate_supaxaxx.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
Unbalanced peptidergic inhibition in superficial cortex underlies seizure activity (Hall et al 2015)
integrate_supbaskx.f
*
Other models using integrate_supbaskx.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
Unbalanced peptidergic inhibition in superficial cortex underlies seizure activity (Hall et al 2015)
integrate_supLTSX.f
*
Other models using integrate_supLTSX.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
Unbalanced peptidergic inhibition in superficial cortex underlies seizure activity (Hall et al 2015)
integrate_supng.f
*
Other models using integrate_supng.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
Unbalanced peptidergic inhibition in superficial cortex underlies seizure activity (Hall et al 2015)
integrate_suppyrFRBxPB.f
*
Other models using integrate_suppyrFRBxPB.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
Unbalanced peptidergic inhibition in superficial cortex underlies seizure activity (Hall et al 2015)
integrate_suppyrRS.f
*
Other models using integrate_suppyrRS.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
Unbalanced peptidergic inhibition in superficial cortex underlies seizure activity (Hall et al 2015)
Unbalanced peptidergic inhibition in superficial cortex underlies seizure activity (Hall et al 2015)
integrate_suppyrRSXPB.f
*
Other models using integrate_suppyrRSXPB.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
Unbalanced peptidergic inhibition in superficial cortex underlies seizure activity (Hall et al 2015)
integrate_tcrxB.f
*
Other models using integrate_tcrxB.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
Unbalanced peptidergic inhibition in superficial cortex underlies seizure activity (Hall et al 2015)
integrate_tuftIBVx3B.f
*
Other models using integrate_tuftIBVx3B.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
Unbalanced peptidergic inhibition in superficial cortex underlies seizure activity (Hall et al 2015)
integrate_tuftRSXXB.f
*
Other models using integrate_tuftRSXXB.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
Unbalanced peptidergic inhibition in superficial cortex underlies seizure activity (Hall et al 2015)
makefile
*
Other models using makefile:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
Unbalanced peptidergic inhibition in superficial cortex underlies seizure activity (Hall et al 2015)
otis_table_setup.f
*
Other models using otis_table_setup.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
Unbalanced peptidergic inhibition in superficial cortex underlies seizure activity (Hall et al 2015)
spikewaveS96.f
spikewaveS96.pdf
synaptic_map_construct.f
*
Other models using synaptic_map_construct.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
Unbalanced peptidergic inhibition in superficial cortex underlies seizure activity (Hall et al 2015)
File not selected
<- Select file from this column.
