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Fast Spiking Basket cells (Tzilivaki et al 2019)
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Model Information
Model File
Accession:
237595
"Interneurons are critical for the proper functioning of neural circuits. While often morphologically complex, dendritic integration and its role in neuronal output have been ignored for decades, treating interneurons as linear point neurons. Exciting new findings suggest that interneuron dendrites support complex, nonlinear computations: sublinear integration of EPSPs in the cerebellum, coupled to supralinear calcium accumulations and supralinear voltage integration in the hippocampus. These findings challenge the point neuron dogma and call for a new theory of interneuron arithmetic. Using detailed, biophysically constrained models, we predict that dendrites of FS basket cells in both hippocampus and mPFC come in two flavors: supralinear, supporting local sodium spikes within large-volume branches and sublinear, in small-volume branches. Synaptic activation of varying sets of these dendrites leads to somatic firing variability that cannot be explained by the point neuron reduction. Instead, a 2-stage Artificial Neural Network (ANN), with both sub- and supralinear hidden nodes, captures most of the variance. We propose that FS basket cells have substantially expanded computational capabilities sub-served by their non-linear dendrites and act as a 2-layer ANN."
Reference:
1 .
Tzilivaki A, Kastellakis G, Poirazi P (2019) Challenging the point neuron dogma: FS basket cells as 2-stage nonlinear integrators
Nature Communications
10(1)
:3664
[
PubMed
]
Citations
Citation Browser
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Hippocampus;
Prefrontal cortex (PFC);
Cell Type(s):
Hippocampus CA3 interneuron basket GABA cell;
Neocortex layer 5 interneuron;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
MATLAB;
Python;
Model Concept(s):
Active Dendrites;
Detailed Neuronal Models;
Implementer(s):
Tzilivaki, Alexandra [alexandra.tzilivaki at charite.de];
Kastellakis, George [gkastel at gmail.com];
Search NeuronDB
for information about:
Hippocampus CA3 interneuron basket GABA cell
;
/
TzilivakiEtal_FSBCs_model
Multicompartmental_Biophysical_models
mechanism
x86_64
.libs
ampa.mod
*
Other models using ampa.mod:
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
ampain.mod
*
Other models using ampain.mod:
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
cadyn.mod
*
Other models using cadyn.mod:
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
cadynin.mod
*
Other models using cadynin.mod:
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
cal.mod
*
Other models using cal.mod:
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
calc.mod
*
Other models using calc.mod:
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
calcb.mod
*
Other models using calcb.mod:
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
can.mod
*
Other models using can.mod:
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
cancr.mod
*
Other models using cancr.mod:
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
canin.mod
*
Other models using canin.mod:
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
car.mod
*
Other models using car.mod:
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
cat.mod
*
Other models using cat.mod:
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
catcb.mod
*
Other models using catcb.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
cpampain.mod
*
Other models using cpampain.mod:
Fast Spiking Basket cells (Tzilivaki et al 2019)
gabaa.mod
*
Other models using gabaa.mod:
Fast Spiking Basket cells (Tzilivaki et al 2019)
L5 PFC microcircuit used to study persistent activity (Papoutsi et al. 2014, 2013)
L5 PFC pyramidal neurons (Papoutsi et al. 2017)
Layer V PFC pyramidal neuron used to study persistent activity (Sidiropoulou & Poirazi 2012)
Linear vs non-linear integration in CA1 oblique dendrites (Gómez González et al. 2011)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
gabaain.mod
*
Other models using gabaain.mod:
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
gabab.mod
*
Other models using gabab.mod:
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
h.mod
*
Other models using h.mod:
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
hcb.mod
*
Other models using hcb.mod:
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
hin.mod
*
Other models using hin.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
ican.mod
*
Other models using ican.mod:
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
iccb.mod
*
Other models using iccb.mod:
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
iccr.mod
*
Other models using iccr.mod:
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
icin.mod
*
Other models using icin.mod:
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
iks.mod
*
Other models using iks.mod:
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
ikscb.mod
*
Other models using ikscb.mod:
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
ikscr.mod
*
Other models using ikscr.mod:
CA1 network model for place cell dynamics (Turi et al 2019)
CA1 network model: interneuron contributions to epileptic deficits (Shuman et al 2019)
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
iksin.mod
*
Other models using iksin.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
kadist.mod
*
Other models using kadist.mod:
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
kadistcr.mod
*
Other models using kadistcr.mod:
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
kadistin.mod
*
Other models using kadistin.mod:
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
kaprox.mod
*
Other models using kaprox.mod:
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
kaproxcb.mod
*
Other models using kaproxcb.mod:
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
kaproxin.mod
*
Other models using kaproxin.mod:
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
kca.mod
*
Other models using kca.mod:
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
kcain.mod
*
Other models using kcain.mod:
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
kct.mod
*
Other models using kct.mod:
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
kctin.mod
*
Other models using kctin.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
kdr.mod
*
Other models using kdr.mod:
Fast Spiking Basket cells (Tzilivaki et al 2019)
L5 PFC microcircuit used to study persistent activity (Papoutsi et al. 2014, 2013)
Neocortical pyramidal neuron: deep; effects of dopamine (Durstewitz et al 2000)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
kdrcb.mod
*
Other models using kdrcb.mod:
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
kdrcr.mod
*
Other models using kdrcr.mod:
CA1 network model for place cell dynamics (Turi et al 2019)
CA1 network model: interneuron contributions to epileptic deficits (Shuman et al 2019)
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
kdrin.mod
*
Other models using kdrin.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
naf.mod
*
Other models using naf.mod:
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
nafcb.mod
*
Other models using nafcb.mod:
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
nafcr.mod
*
Other models using nafcr.mod:
CA1 network model for place cell dynamics (Turi et al 2019)
CA1 network model: interneuron contributions to epileptic deficits (Shuman et al 2019)
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
nafin.mod
*
Other models using nafin.mod:
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
nafx.mod
*
Other models using nafx.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
nap.mod
*
Other models using nap.mod:
Fast Spiking Basket cells (Tzilivaki et al 2019)
Neocortical pyramidal neuron: deep; effects of dopamine (Durstewitz et al 2000)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
netstim.mod
*
Other models using netstim.mod:
Fast Spiking Basket cells (Tzilivaki et al 2019)
L5 PFC microcircuit used to study persistent activity (Papoutsi et al. 2014, 2013)
Linear vs non-linear integration in CA1 oblique dendrites (Gómez González et al. 2011)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
NMDA.mod
*
Other models using NMDA.mod:
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
NMDAIN.mod
*
Other models using NMDAIN.mod:
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
sinclamp.mod
*
Other models using sinclamp.mod:
Fast Spiking Basket cells (Tzilivaki et al 2019)
L5 PFC microcircuit used to study persistent activity (Papoutsi et al. 2014, 2013)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
vecstim.mod
*
Other models using vecstim.mod:
CA1 network model for place cell dynamics (Turi et al 2019)
CA1 network model: interneuron contributions to epileptic deficits (Shuman et al 2019)
Fast Spiking Basket cells (Tzilivaki et al 2019)
L5 PFC microcircuit used to study persistent activity (Papoutsi et al. 2014, 2013)
ampa.c
ampa.lo
ampain.c
ampain.lo
cadyn.c
cadyn.lo
cadynin.c
cadynin.lo
cal.c
cal.lo
calc.c
calc.lo
calcb.c
calcb.lo
can.c
can.lo
cancr.c
cancr.lo
canin.c
canin.lo
car.c
car.lo
cat.c
cat.lo
catcb.c
catcb.lo
cpampain.c
cpampain.lo
gabaa.c
gabaa.lo
gabaain.c
gabaain.lo
gabab.c
gabab.lo
h.c
h.lo
hcb.c
hcb.lo
hin.c
hin.lo
ican.c
ican.lo
iccb.c
iccb.lo
iccr.c
iccr.lo
icin.c
icin.lo
iks.c
iks.lo
ikscb.c
ikscb.lo
ikscr.c
ikscr.lo
iksin.c
iksin.lo
kadist.c
kadist.lo
kadistcr.c
kadistcr.lo
kadistin.c
kadistin.lo
kaprox.c
kaprox.lo
kaproxcb.c
kaproxcb.lo
kaproxin.c
kaproxin.lo
kca.c
kca.lo
kcain.c
kcain.lo
kct.c
kct.lo
kctin.c
kctin.lo
kdr.c
kdr.lo
kdrcb.c
kdrcb.lo
kdrcr.c
kdrcr.lo
kdrin.c
kdrin.lo
libnrnmech.la
*
Other models using libnrnmech.la:
Fast Spiking Basket cells (Tzilivaki et al 2019)
mod_func.c
mod_func.lo
*
Other models using mod_func.lo:
Model of peripheral nerve with ephaptic coupling (Capllonch-Juan & Sepulveda 2020)
Model of peripheral nerve with ephaptic coupling (Capllonch-Juan & Sepulveda 2020)
Model of peripheral nerve with ephaptic coupling (Capllonch-Juan & Sepulveda 2020)
Model of peripheral nerve with ephaptic coupling (Capllonch-Juan & Sepulveda 2020)
Model of peripheral nerve with ephaptic coupling (Capllonch-Juan & Sepulveda 2020)
Model of peripheral nerve with ephaptic coupling (Capllonch-Juan & Sepulveda 2020)
Model of peripheral nerve with ephaptic coupling (Capllonch-Juan & Sepulveda 2020)
naf.c
naf.lo
nafcb.c
nafcb.lo
nafcr.c
nafcr.lo
nafin.c
nafin.lo
nafx.c
nafx.lo
nap.c
nap.lo
netstim.c
netstim.lo
NMDA.c
NMDA.lo
NMDAIN.c
NMDAIN.lo
sinclamp.c
sinclamp.lo
special
vecstim.c
vecstim.lo
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