/* Created by Language version: 6.2.0 */
/* NOT VECTORIZED */
#define NRN_VECTORIZED 0
#include <stdio.h>
#include <stdlib.h>
#include <math.h>
#include "scoplib_ansi.h"
#undef PI
#define nil 0
#include "md1redef.h"
#include "section.h"
#include "nrniv_mf.h"
#include "md2redef.h"
#if METHOD3
extern int _method3;
#endif
#if !NRNGPU
#undef exp
#define exp hoc_Exp
extern double hoc_Exp(double);
#endif
#define nrn_init _nrn_init__GABAa
#define _nrn_initial _nrn_initial__GABAa
#define nrn_cur _nrn_cur__GABAa
#define _nrn_current _nrn_current__GABAa
#define nrn_jacob _nrn_jacob__GABAa
#define nrn_state _nrn_state__GABAa
#define _net_receive _net_receive__GABAa
#define release release__GABAa
#define _threadargscomma_ /**/
#define _threadargsprotocomma_ /**/
#define _threadargs_ /**/
#define _threadargsproto_ /**/
/*SUPPRESS 761*/
/*SUPPRESS 762*/
/*SUPPRESS 763*/
/*SUPPRESS 765*/
extern double *getarg();
static double *_p; static Datum *_ppvar;
#define t nrn_threads->_t
#define dt nrn_threads->_dt
#define i _p[0]
#define g _p[1]
#define gmax _p[2]
#define Ron _p[3]
#define Roff _p[4]
#define synon _p[5]
#define DRon _p[6]
#define DRoff _p[7]
#define _g _p[8]
#define _tsav _p[9]
#define _nd_area *_ppvar[0]._pval
#if MAC
#if !defined(v)
#define v _mlhv
#endif
#if !defined(h)
#define h _mlhh
#endif
#endif
#if defined(__cplusplus)
extern "C" {
#endif
static int hoc_nrnpointerindex = -1;
/* external NEURON variables */
/* declaration of user functions */
static int _mechtype;
extern void _nrn_cacheloop_reg(int, int);
extern void hoc_register_prop_size(int, int, int);
extern void hoc_register_limits(int, HocParmLimits*);
extern void hoc_register_units(int, HocParmUnits*);
extern void nrn_promote(Prop*, int, int);
extern Memb_func* memb_func;
extern Prop* nrn_point_prop_;
static int _pointtype;
static void* _hoc_create_pnt(_ho) Object* _ho; { void* create_point_process();
return create_point_process(_pointtype, _ho);
}
static void _hoc_destroy_pnt();
static double _hoc_loc_pnt(_vptr) void* _vptr; {double loc_point_process();
return loc_point_process(_pointtype, _vptr);
}
static double _hoc_has_loc(_vptr) void* _vptr; {double has_loc_point();
return has_loc_point(_vptr);
}
static double _hoc_get_loc_pnt(_vptr)void* _vptr; {
double get_loc_point_process(); return (get_loc_point_process(_vptr));
}
extern void _nrn_setdata_reg(int, void(*)(Prop*));
static void _setdata(Prop* _prop) {
_p = _prop->param; _ppvar = _prop->dparam;
}
static void _hoc_setdata(void* _vptr) { Prop* _prop;
_prop = ((Point_process*)_vptr)->_prop;
_setdata(_prop);
}
/* connect user functions to hoc names */
static VoidFunc hoc_intfunc[] = {
0,0
};
static Member_func _member_func[] = {
"loc", _hoc_loc_pnt,
"has_loc", _hoc_has_loc,
"get_loc", _hoc_get_loc_pnt,
0, 0
};
/* declare global and static user variables */
#define Alpha Alpha_GABAa
double Alpha = 5;
#define Beta Beta_GABAa
double Beta = 0.18;
#define Cdur Cdur_GABAa
double Cdur = 1;
#define Cmax Cmax_GABAa
double Cmax = 1;
#define Erev Erev_GABAa
double Erev = -80;
#define Rtau Rtau_GABAa
double Rtau = 0;
#define Rinf Rinf_GABAa
double Rinf = 0;
/* some parameters have upper and lower limits */
static HocParmLimits _hoc_parm_limits[] = {
0,0,0
};
static HocParmUnits _hoc_parm_units[] = {
"Cmax_GABAa", "mM",
"Cdur_GABAa", "ms",
"Alpha_GABAa", "/ms",
"Beta_GABAa", "/ms",
"Erev_GABAa", "mV",
"Rtau_GABAa", "ms",
"i", "nA",
"g", "umho",
0,0
};
static double Roff0 = 0;
static double Ron0 = 0;
static double delta_t = 0.01;
static double v = 0;
/* connect global user variables to hoc */
static DoubScal hoc_scdoub[] = {
"Cmax_GABAa", &Cmax_GABAa,
"Cdur_GABAa", &Cdur_GABAa,
"Alpha_GABAa", &Alpha_GABAa,
"Beta_GABAa", &Beta_GABAa,
"Erev_GABAa", &Erev_GABAa,
"Rinf_GABAa", &Rinf_GABAa,
"Rtau_GABAa", &Rtau_GABAa,
0,0
};
static DoubVec hoc_vdoub[] = {
0,0,0
};
static double _sav_indep;
static void nrn_alloc(Prop*);
static void nrn_init(_NrnThread*, _Memb_list*, int);
static void nrn_state(_NrnThread*, _Memb_list*, int);
static void nrn_cur(_NrnThread*, _Memb_list*, int);
static void nrn_jacob(_NrnThread*, _Memb_list*, int);
static void _hoc_destroy_pnt(_vptr) void* _vptr; {
destroy_point_process(_vptr);
}
static int _ode_count(int);
static void _ode_map(int, double**, double**, double*, Datum*, double*, int);
static void _ode_spec(_NrnThread*, _Memb_list*, int);
static void _ode_matsol(_NrnThread*, _Memb_list*, int);
#define _cvode_ieq _ppvar[3]._i
static void _ode_matsol_instance1(_threadargsproto_);
/* connect range variables in _p that hoc is supposed to know about */
static const char *_mechanism[] = {
"6.2.0",
"GABAa",
0,
"i",
"g",
"gmax",
0,
"Ron",
"Roff",
0,
0};
extern Prop* need_memb(Symbol*);
static void nrn_alloc(Prop* _prop) {
Prop *prop_ion;
double *_p; Datum *_ppvar;
if (nrn_point_prop_) {
_prop->_alloc_seq = nrn_point_prop_->_alloc_seq;
_p = nrn_point_prop_->param;
_ppvar = nrn_point_prop_->dparam;
}else{
_p = nrn_prop_data_alloc(_mechtype, 10, _prop);
/*initialize range parameters*/
}
_prop->param = _p;
_prop->param_size = 10;
if (!nrn_point_prop_) {
_ppvar = nrn_prop_datum_alloc(_mechtype, 4, _prop);
}
_prop->dparam = _ppvar;
/*connect ionic variables to this model*/
}
static void _initlists();
/* some states have an absolute tolerance */
static Symbol** _atollist;
static HocStateTolerance _hoc_state_tol[] = {
0,0
};
#define _tqitem &(_ppvar[2]._pvoid)
static void _net_receive(Point_process*, double*, double);
extern Symbol* hoc_lookup(const char*);
extern void _nrn_thread_reg(int, int, void(*)(Datum*));
extern void _nrn_thread_table_reg(int, void(*)(double*, Datum*, Datum*, _NrnThread*, int));
extern void hoc_register_tolerance(int, HocStateTolerance*, Symbol***);
extern void _cvode_abstol( Symbol**, double*, int);
void _gabaa_reg() {
int _vectorized = 0;
_initlists();
_pointtype = point_register_mech(_mechanism,
nrn_alloc,nrn_cur, nrn_jacob, nrn_state, nrn_init,
hoc_nrnpointerindex, 0,
_hoc_create_pnt, _hoc_destroy_pnt, _member_func);
_mechtype = nrn_get_mechtype(_mechanism[1]);
_nrn_setdata_reg(_mechtype, _setdata);
hoc_register_prop_size(_mechtype, 10, 4);
hoc_register_dparam_semantics(_mechtype, 0, "area");
hoc_register_dparam_semantics(_mechtype, 1, "pntproc");
hoc_register_dparam_semantics(_mechtype, 2, "netsend");
hoc_register_dparam_semantics(_mechtype, 3, "cvodeieq");
hoc_register_cvode(_mechtype, _ode_count, _ode_map, _ode_spec, _ode_matsol);
hoc_register_tolerance(_mechtype, _hoc_state_tol, &_atollist);
pnt_receive[_mechtype] = _net_receive;
pnt_receive_size[_mechtype] = 5;
hoc_register_var(hoc_scdoub, hoc_vdoub, hoc_intfunc);
ivoc_help("help ?1 GABAa /home/cluster/aleka/MainPath/Desktop/FSBC_model/Multicompartmental_Biophysical_models/mechanism/x86_64/gabaa.mod\n");
hoc_register_limits(_mechtype, _hoc_parm_limits);
hoc_register_units(_mechtype, _hoc_parm_units);
}
static int _reset;
static char *modelname = "minimal model of GABAa receptors";
static int error;
static int _ninits = 0;
static int _match_recurse=1;
static void _modl_cleanup(){ _match_recurse=1;}
static int _ode_spec1(_threadargsproto_);
/*static int _ode_matsol1(_threadargsproto_);*/
static int _slist1[2], _dlist1[2];
static int release(_threadargsproto_);
/*CVODE*/
static int _ode_spec1 () {_reset=0;
{
DRon = ( synon * Rinf - Ron ) / Rtau ;
DRoff = - Beta * Roff ;
}
return _reset;
}
static int _ode_matsol1 () {
DRon = DRon / (1. - dt*( ( ( ( - 1.0 ) ) ) / Rtau )) ;
DRoff = DRoff / (1. - dt*( ( - Beta )*( 1.0 ) )) ;
return 0;
}
/*END CVODE*/
static int release () {_reset=0;
{
Ron = Ron + (1. - exp(dt*(( ( ( - 1.0 ) ) ) / Rtau)))*(- ( ( ( ( synon )*( Rinf ) ) ) / Rtau ) / ( ( ( ( - 1.0 ) ) ) / Rtau ) - Ron) ;
Roff = Roff + (1. - exp(dt*(( - Beta )*( 1.0 ))))*(- ( 0.0 ) / ( ( - Beta )*( 1.0 ) ) - Roff) ;
}
return 0;
}
static void _net_receive (_pnt, _args, _lflag) Point_process* _pnt; double* _args; double _lflag;
{ _p = _pnt->_prop->param; _ppvar = _pnt->_prop->dparam;
if (_tsav > t){ extern char* hoc_object_name(); hoc_execerror(hoc_object_name(_pnt->ob), ":Event arrived out of order. Must call ParallelContext.set_maxstep AFTER assigning minimum NetCon.delay");}
_tsav = t; if (_lflag == 1. ) {*(_tqitem) = 0;}
{
if ( _lflag == 0.0 ) {
_args[2] = _args[2] + 1.0 ;
if ( ! _args[1] ) {
_args[3] = _args[3] * exp ( - Beta * ( t - _args[4] ) ) ;
_args[4] = t ;
_args[1] = 1.0 ;
synon = synon + _args[0] ;
if (nrn_netrec_state_adjust && !cvode_active_){
/* discon state adjustment for cnexp case (rate uses no local variable) */
double __state = Ron;
double __primary = (Ron + _args[3] ) - __state;
__primary += ( 1. - exp( 0.5*dt*( ( ( ( - 1.0 ) ) ) / Rtau ) ) )*( - ( ( ( ( synon )*( Rinf ) ) ) / Rtau ) / ( ( ( ( - 1.0 ) ) ) / Rtau ) - __primary );
Ron += __primary;
} else {
Ron = Ron + _args[3] ;
}
if (nrn_netrec_state_adjust && !cvode_active_){
/* discon state adjustment for cnexp case (rate uses no local variable) */
double __state = Roff;
double __primary = (Roff - _args[3] ) - __state;
__primary += ( 1. - exp( 0.5*dt*( ( - Beta )*( 1.0 ) ) ) )*( - ( 0.0 ) / ( ( - Beta )*( 1.0 ) ) - __primary );
Roff += __primary;
} else {
Roff = Roff - _args[3] ;
}
}
net_send ( _tqitem, _args, _pnt, t + Cdur , _args[2] ) ;
}
if ( _lflag == _args[2] ) {
_args[3] = _args[0] * Rinf + ( _args[3] - _args[0] * Rinf ) * exp ( - ( t - _args[4] ) / Rtau ) ;
_args[4] = t ;
synon = synon - _args[0] ;
if (nrn_netrec_state_adjust && !cvode_active_){
/* discon state adjustment for cnexp case (rate uses no local variable) */
double __state = Ron;
double __primary = (Ron - _args[3] ) - __state;
__primary += ( 1. - exp( 0.5*dt*( ( ( ( - 1.0 ) ) ) / Rtau ) ) )*( - ( ( ( ( synon )*( Rinf ) ) ) / Rtau ) / ( ( ( ( - 1.0 ) ) ) / Rtau ) - __primary );
Ron += __primary;
} else {
Ron = Ron - _args[3] ;
}
if (nrn_netrec_state_adjust && !cvode_active_){
/* discon state adjustment for cnexp case (rate uses no local variable) */
double __state = Roff;
double __primary = (Roff + _args[3] ) - __state;
__primary += ( 1. - exp( 0.5*dt*( ( - Beta )*( 1.0 ) ) ) )*( - ( 0.0 ) / ( ( - Beta )*( 1.0 ) ) - __primary );
Roff += __primary;
} else {
Roff = Roff + _args[3] ;
}
_args[1] = 0.0 ;
}
gmax = _args[0] ;
} }
static int _ode_count(int _type){ return 2;}
static void _ode_spec(_NrnThread* _nt, _Memb_list* _ml, int _type) {
Datum* _thread;
Node* _nd; double _v; int _iml, _cntml;
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
v = NODEV(_nd);
_ode_spec1 ();
}}
static void _ode_map(int _ieq, double** _pv, double** _pvdot, double* _pp, Datum* _ppd, double* _atol, int _type) {
int _i; _p = _pp; _ppvar = _ppd;
_cvode_ieq = _ieq;
for (_i=0; _i < 2; ++_i) {
_pv[_i] = _pp + _slist1[_i]; _pvdot[_i] = _pp + _dlist1[_i];
_cvode_abstol(_atollist, _atol, _i);
}
}
static void _ode_matsol_instance1(_threadargsproto_) {
_ode_matsol1 ();
}
static void _ode_matsol(_NrnThread* _nt, _Memb_list* _ml, int _type) {
Datum* _thread;
Node* _nd; double _v; int _iml, _cntml;
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
v = NODEV(_nd);
_ode_matsol_instance1(_threadargs_);
}}
static void initmodel() {
int _i; double _save;_ninits++;
_save = t;
t = 0.0;
{
Roff = Roff0;
Ron = Ron0;
{
Rinf = Cmax * Alpha / ( Cmax * Alpha + Beta ) ;
Rtau = 1.0 / ( ( Alpha * Cmax ) + Beta ) ;
synon = 0.0 ;
}
_sav_indep = t; t = _save;
}
}
static void nrn_init(_NrnThread* _nt, _Memb_list* _ml, int _type){
Node *_nd; double _v; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_tsav = -1e20;
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
v = _v;
initmodel();
}}
static double _nrn_current(double _v){double _current=0.;v=_v;{ {
g = ( Ron + Roff ) * 1.0 ;
i = g * ( v - Erev ) ;
}
_current += i;
} return _current;
}
static void nrn_cur(_NrnThread* _nt, _Memb_list* _ml, int _type){
Node *_nd; int* _ni; double _rhs, _v; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
_g = _nrn_current(_v + .001);
{ _rhs = _nrn_current(_v);
}
_g = (_g - _rhs)/.001;
_g *= 1.e2/(_nd_area);
_rhs *= 1.e2/(_nd_area);
#if CACHEVEC
if (use_cachevec) {
VEC_RHS(_ni[_iml]) -= _rhs;
}else
#endif
{
NODERHS(_nd) -= _rhs;
}
}}
static void nrn_jacob(_NrnThread* _nt, _Memb_list* _ml, int _type){
Node *_nd; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml];
#if CACHEVEC
if (use_cachevec) {
VEC_D(_ni[_iml]) += _g;
}else
#endif
{
_nd = _ml->_nodelist[_iml];
NODED(_nd) += _g;
}
}}
static void nrn_state(_NrnThread* _nt, _Memb_list* _ml, int _type){
Node *_nd; double _v = 0.0; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
v=_v;
{
{ error = release();
if(error){fprintf(stderr,"at line 109 in file gabaa.mod:\n SOLVE release METHOD cnexp\n"); nrn_complain(_p); abort_run(error);}
}}}
}
static void terminal(){}
static void _initlists() {
int _i; static int _first = 1;
if (!_first) return;
_slist1[0] = &(Ron) - _p; _dlist1[0] = &(DRon) - _p;
_slist1[1] = &(Roff) - _p; _dlist1[1] = &(DRoff) - _p;
_first = 0;
}
