MicrocircuitDB: Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites (Bloss et al 2018)

Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites (Bloss et al 2018)

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Accession:237728

" ... Here we show that single presynaptic axons form multiple, spatially clustered inputs onto the distal, but not proximal, dendrites of CA1 pyramidal neurons. These compound connections exhibit ultrastructural features indicative of strong synapses and occur much more commonly in entorhinal than in thalamic afferents. Computational simulations revealed that compound connections depolarize dendrites in a biophysically efficient manner, owing to their inherent spatiotemporal clustering. ..."
Reference:
1 . Bloss EB, Cembrowski MS, Karsh B, Colonell J, Fetter RD, Spruston N (2018) Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites. Nat Neurosci 21:353-363 [PubMed]

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Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):	Hippocampus CA1 pyramidal GLU cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	NEURON;
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channelParameters.hoc *

initializationAndRun.hoc

v_init=-65
global_ra=150
Cm=1.0
Rm=40000
Vleak=-65

proc initChannels(){
	forall {
		insert pas  g_pas=1/(Rm)  Ra=global_ra  e_pas=Vleak
	}
}