Optimal synaptic assignment for locomotory behavior in C. elegans (Rakowski & Karbowski 2017)


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Accession:238985
"The detailed knowledge of C. elegans connectome for 3 decades has not contributed dramatically to our understanding of worm’s behavior. One of main reasons for this situation has been the lack of data on the type of synaptic signaling between particular neurons in the worm’s connectome. The aim of this study was to determine synaptic polarities for each connection in a small pre-motor circuit controlling locomotion. Even in this compact network of just 7 neurons the space of all possible patterns of connection types (excitation vs. inhibition) is huge. To deal effectively with this combinatorial problem we devised a novel and relatively fast technique based on genetic algorithms and large-scale parallel computations, which we combined with detailed neurophysiological modeling of interneuron dynamics and compared the theory to the available behavioral data. As a result of these massive computations, we found that the optimal connectivity pattern that matches the best locomotory data is the one in which all interneuron connections are inhibitory, even those terminating on motor neurons. ..."
Reference:
1 . Rakowski F, Karbowski J (2017) Optimal synaptic signaling connectome for locomotory behavior in Caenorhabditis elegans: Design minimizing energy cost. PLoS Comput Biol 13:e1005834 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s): Acetylcholine;
Simulation Environment: Java (web link to model); Mathematica (web link to model);
Model Concept(s): Invertebrate;
Implementer(s): Rakowski, Franciszek ;
Search NeuronDB for information about:  Acetylcholine;
(located via links below)
#!/bin/sh

# An example hook script to verify what is about to be pushed.  Called by "git
# push" after it has checked the remote status, but before anything has been
# pushed.  If this script exits with a non-zero status nothing will be pushed.
#
# This hook is called with the following parameters:
#
# $1 -- Name of the remote to which the push is being done
# $2 -- URL to which the push is being done
#
# If pushing without using a named remote those arguments will be equal.
#
# Information about the commits which are being pushed is supplied as lines to
# the standard input in the form:
#
#   <local ref> <local sha1> <remote ref> <remote sha1>
#
# This sample shows how to prevent push of commits where the log message starts
# with "WIP" (work in progress).

remote="$1"
url="$2"

z40=0000000000000000000000000000000000000000

while read local_ref local_sha remote_ref remote_sha
do
	if [ "$local_sha" = $z40 ]
	then
		# Handle delete
		:
	else
		if [ "$remote_sha" = $z40 ]
		then
			# New branch, examine all commits
			range="$local_sha"
		else
			# Update to existing branch, examine new commits
			range="$remote_sha..$local_sha"
		fi

		# Check for WIP commit
		commit=`git rev-list -n 1 --grep '^WIP' "$range"`
		if [ -n "$commit" ]
		then
			echo >&2 "Found WIP commit in $local_ref, not pushing"
			exit 1
		fi
	fi
done

exit 0