Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:244262
"... High frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) suppresses parkinsonian motor symptoms and modulates cortical activity. ... Cortical evoked potentials (cEP) generated by STN DBS reflect the response of cortex to subcortical stimulation, and the goal was to determine the neural origin of cEP using a two-step approach. First, we recorded cEP over ipsilateral primary motor cortex during different frequencies of STN DBS in awake healthy and unilateral 6-OHDA lesioned parkinsonian rats. Second, we used a biophysically-based model of the thalamocortical network to deconstruct the neural origin of the cEP. The in vivo cEP included short (R1), intermediate (R2) and long-latency (R3) responses. Model-based cortical responses to simulated STN DBS matched remarkably well the in vivo responses. R1 was generated by antidromic activation of layer 5 pyramidal neurons, while recurrent activation of layer 5 pyramidal neurons via excitatory axon collaterals reproduced R2. R3 was generated by polysynaptic activation of layer 2/3 pyramidal neurons via the cortico-thalamic-cortical pathway. Antidromic activation of the hyperdirect pathway and subsequent intracortical and cortico-thalamo-cortical synaptic interactions were sufficient to generate cEP by STN DBS, and orthodromic activation through basal ganglia-thalamus-cortex pathways was not required. These results demonstrate the utility of cEP to determine the neural elements activated by STN DBS that might modulate cortical activity and contribute to the suppression of parkinsonian symptoms."
Reference:
1 . Kumaravelu K, Oza CS, Behrend CE, Grill WM (2018) Model-based deconstruction of cortical evoked potentials generated by subthalamic nucleus deep brain stimulation. J Neurophysiol 120:662-680 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Neocortex; Thalamus;
Cell Type(s): Neocortex M1 L6 pyramidal corticothalamic GLU cell; Neocortex M1 L5B pyramidal pyramidal tract GLU cell; Neocortex M1 L4 stellate GLU cell; Hodgkin-Huxley neuron; Neocortex layer 4 neuron; Neocortex fast spiking (FS) interneuron; Neocortex primary motor area pyramidal layer 5 corticospinal cell;
Channel(s): I Na,p; I K; I Sodium; I_KD; I Calcium; I T low threshold; I L high threshold; I_AHP;
Gap Junctions: Gap junctions;
Receptor(s): AMPA; Gaba; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Deep brain stimulation; Evoked LFP;
Implementer(s): Kumaravelu, Karthik [kk192 at duke.edu];
Search NeuronDB for information about:  Neocortex M1 L6 pyramidal corticothalamic GLU cell; Neocortex M1 L5B pyramidal pyramidal tract GLU cell; Neocortex M1 L4 stellate GLU cell; AMPA; NMDA; Gaba; I Na,p; I L high threshold; I T low threshold; I K; I Sodium; I Calcium; I_AHP; I_KD; Gaba; Glutamate;
/
cEP_stndbs_4.5hz
dat
deepaxax_v_F.dat *
deepbask_v_F.dat *
deepLTS_v_F.dat *
nointeraction.spk *
nontuftRS_v_F.dat *
nrntest.spk *
nRT_v_F.dat *
p2ctest.spk *
spinstell_v_F.dat *
supaxax_v_F.dat *
supbask_v_F.dat *
supLTS_v_F.dat *
suppyrFRB_v_F.dat *
suppyrRS_v_F.dat *
TCR_v_F.dat *
tuftIB_v_F.dat *
tuftRS_v_F.dat *
                            
    0.1000  -69.9081
    0.2000  -69.6263
    0.3000  -69.2717
    0.4000  -68.8987
    0.5000  -68.5270
    0.6000  -68.1633
    0.7000  -67.8104
    0.8000  -67.4675
    0.9000  -67.1345
    1.0000  -66.8096
    1.1000  -66.4908
    1.2000  -66.1773
    1.3000  -65.8678
    1.4000  -65.5600
    1.5000  -65.2527
    1.6000  -64.9450
    1.7000  -64.6365
    1.8000  -64.3254
    1.9000  -64.0094
    2.0000  -63.6888
    2.1000  -63.3629
    2.2000  -63.0284
    2.3000  -62.6844
    2.4000  -62.3312
    2.5000  -61.9629
    2.6000  -61.5815
    2.7000  -61.1795
    2.8000  -60.7563
    2.9000  -60.3050
    3.0000  -59.8181
    3.1000  -59.2859
    3.2000  -58.6946
    3.3000  -58.0214
    3.4000  -57.2294
    3.5000  -56.2546
    3.6000  -54.9656
    3.7000  -53.0392
    3.8000  -49.4142
    3.9000  -36.9921
    4.0000   41.8657
    4.1000   27.0505
    4.2000   -6.3156
    4.3000  -27.5695
    4.4000  -61.5176
    4.5000  -74.6318
    4.6000  -72.1396
    4.7000  -67.6748
    4.8000  -64.7205
    4.9000  -63.7585
    5.0000  -63.7353
    5.1000  -63.9266
    5.2000  -64.0247
    5.3000  -63.9698
    5.4000  -63.7674
    5.5000  -63.4333
    5.6000  -62.9954
    5.7000  -62.4807
    5.8000  -61.9117
    5.9000  -61.3023
    6.0000  -60.6536
    6.1000  -59.9578
    6.2000  -59.1918
    6.3000  -58.3189
    6.4000  -57.2681
    6.5000  -55.9029
    6.6000  -53.9087
    6.7000  -50.2593
    6.8000  -38.4633
    6.9000   40.5095
    7.0000   27.1365
    7.1000   -6.4377
    7.2000  -27.7854
    7.3000  -63.3289
    7.4000  -75.9712
    7.5000  -72.7635
    7.6000  -68.3802
    7.7000  -66.0654
    7.8000  -65.4750
    7.9000  -65.5859
    8.0000  -65.7736
    8.1000  -65.8062
    8.2000  -65.6131
    8.3000  -65.1783
    8.4000  -64.5081
    8.5000  -63.6044
    8.6000  -62.4418
    8.7000  -60.9316
    8.8000  -58.8192
    8.9000  -55.2111
    9.0000  -44.4323
    9.1000   38.0886
    9.2000   31.6037
    9.3000   -2.7626
    9.4000  -24.7384
    9.5000  -62.3598
    9.6000  -79.1090
    9.7000  -76.9647
    9.8000  -74.0814
    9.9000  -72.0074
   10.0000  -70.5479
   10.1000  -69.4336
   10.2000  -68.4816
   10.3000  -67.5824
   10.4000  -66.6767
   10.5000  -65.7308
   10.6000  -64.7179
   10.7000  -63.6045
   10.8000  -62.3354
   10.9000  -60.8010
   11.0000  -58.7375
   11.1000  -55.2769
   11.2000  -44.8907
   11.3000   37.4785
   11.4000   32.3230
   11.5000   -1.9350
   11.6000  -23.8920
   11.7000  -60.4053
   11.8000  -79.2224
   11.9000  -77.0190
   12.0000  -74.2100
   12.1000  -72.4302
   12.2000  -71.3502
   12.3000  -70.6162
   12.4000  -70.0418
   12.5000  -69.5120
   12.6000  -68.9660
   12.7000  -68.3802
   12.8000  -67.7494
   12.9000  -67.0750
   13.0000  -66.3579
   13.1000  -65.5959
   13.2000  -64.7823
   13.3000  -63.9035
   13.4000  -62.9374
   13.5000  -61.8459
   13.6000  -60.5560
   13.7000  -58.9093
   13.8000  -56.4582
   13.9000  -51.2275
   14.0000  -23.8733
   14.1000   44.4789
   14.2000   12.6097
   14.3000  -12.9340
   14.4000  -35.3234
   14.5000  -76.1568
   14.6000  -78.0744
   14.7000  -74.1559
   14.8000  -71.7337
   14.9000  -70.8742
   15.0000  -70.7422
   15.1000  -70.7837
   15.2000  -70.8188
   15.3000  -70.7957
   15.4000  -70.6835
   15.5000  -70.4750
   15.6000  -70.1816
   15.7000  -69.8226
   15.8000  -69.4175
   15.9000  -68.9835
   16.0000  -68.5339
   16.1000  -68.0798
   16.2000  -67.6296
   16.3000  -67.1911
   16.4000  -66.7725
   16.5000  -66.3817
   16.6000  -66.0290
   16.7000  -65.7268
   16.8000  -65.4861
   16.9000  -65.3144
   17.0000  -65.2210
   17.1000  -65.2068
   17.2000  -65.2615
   17.3000  -65.3757
   17.4000  -65.5477
   17.5000  -65.7538
   17.6000  -65.9792
   17.7000  -66.2101
   17.8000  -66.4354
   17.9000  -66.6483
   18.0000  -66.8458
   18.1000  -67.0265
   18.2000  -67.1909
   18.3000  -67.3439
   18.4000  -67.4884
   18.5000  -67.6277
   18.6000  -67.7697
   18.7000  -67.9141
   18.8000  -68.0692
   18.9000  -68.2362
   19.0000  -68.4186
   19.1000  -68.6205
   19.2000  -68.8442
   19.3000  -69.0923
   19.4000  -69.3674
   19.5000  -69.6715
   19.6000  -70.0060
   19.7000  -70.3703
   19.8000  -70.7640
   19.9000  -71.1852
   20.0000  -71.6324
   20.1000  -72.1033
   20.2000  -72.5960
   20.3000  -73.1082
   20.4000  -73.6373
   20.5000  -74.1802
   20.6000  -74.7335
   20.7000  -75.2931
   20.8000  -75.8548
   20.9000  -76.4140
   21.0000  -76.9661
   21.1000  -77.5064
   21.2000  -78.0305
   21.3000  -78.5345
   21.4000  -79.0150
   21.5000  -79.4692
   21.6000  -79.8951
   21.7000  -80.2917
   21.8000  -80.6583
   21.9000  -80.9951
   22.0000  -81.3027
   22.1000  -81.5820
   22.2000  -81.8343
   22.3000  -82.0612
   22.4000  -82.2643
   22.5000  -82.4453
   22.6000  -82.6058
   22.7000  -82.7477
   22.8000  -82.8723
   22.9000  -82.9814
   23.0000  -83.0763
   23.1000  -83.1585
   23.2000  -83.2291
   23.3000  -83.2894
   23.4000  -83.3402
   23.5000  -83.3828
   23.6000  -83.4179
   23.7000  -83.4462
   23.8000  -83.4685
   23.9000  -83.4854
   24.0000  -83.4975
   24.1000  -83.5052
   24.2000  -83.5091
   24.3000  -83.5095
   24.4000  -83.5068
   24.5000  -83.5014
   24.6000  -83.4935
   24.7000  -83.4833
   24.8000  -83.4711
   24.9000  -83.4571
   25.0000  -83.4414
   25.1000  -83.4242
   25.2000  -83.4057
   25.3000  -83.3860
   25.4000  -83.3652
   25.5000  -83.3433
   25.6000  -83.3206
   25.7000  -83.2971
   25.8000  -83.2728
   25.9000  -83.2479
   26.0000  -83.2223
   26.1000  -83.1961
   26.2000  -83.1694
   26.3000  -83.1422
   26.4000  -83.1144
   26.5000  -83.0862
   26.6000  -83.0577
   26.7000  -83.0288
   26.8000  -82.9997
   26.9000  -82.9703
   27.0000  -82.9406
   27.1000  -82.9106
   27.2000  -82.8803
   27.3000  -82.8496
   27.4000  -82.8188
   27.5000  -82.7878
   27.6000  -82.7567
   27.7000  -82.7254
   27.8000  -82.6940
   27.9000  -82.6624
   28.0000  -82.6306
   28.1000  -82.5985
   28.2000  -82.5664
   28.3000  -82.5342
   28.4000  -82.5018
   28.5000  -82.4695
   28.6000  -82.4369
   28.7000  -82.4043
   28.8000  -82.3715
   28.9000  -82.3385
   29.0000  -82.3055
   29.1000  -82.2725
   29.2000  -82.2394
   29.3000  -82.2062
   29.4000  -82.1729
   29.5000  -82.1395
   29.6000  -82.1060
   29.7000  -82.0724
   29.8000  -82.0388
   29.9000  -82.0052
   30.0000  -81.9715
   30.1000  -81.9377
   30.2000  -81.9038
   30.3000  -81.8700
   30.4000  -81.8360
   30.5000  -81.8019
   30.6000  -81.7678
   30.7000  -81.7336
   30.8000  -81.6995
   30.9000  -81.6653
   31.0000  -81.6311
   31.1000  -81.5968
   31.2000  -81.5623
   31.3000  -81.5278
   31.4000  -81.4933
   31.5000  -81.4589
   31.6000  -81.4244
   31.7000  -81.3899
   31.8000  -81.3553
   31.9000  -81.3205
   32.0000  -81.2857
   32.1000  -81.2510
   32.2000  -81.2163
   32.3000  -81.1816
   32.4000  -81.1468
   32.5000  -81.1120
   32.6000  -81.0769
   32.7000  -81.0419
   32.8000  -81.0070
   32.9000  -80.9721
   33.0000  -80.9372
   33.1000  -80.9022
   33.2000  -80.8672
   33.3000  -80.8319
   33.4000  -80.7968
   33.5000  -80.7617
   33.6000  -80.7266
   33.7000  -80.6915
   33.8000  -80.6564
   33.9000  -80.6213
   34.0000  -80.5859
   34.1000  -80.5507
   34.2000  -80.5154
   34.3000  -80.4802
   34.4000  -80.4450
   34.5000  -80.4099
   34.6000  -80.3747
   34.7000  -80.3392
   34.8000  -80.3038
   34.9000  -80.2685
   35.0000  -80.2333
   35.1000  -80.1981
   35.2000  -80.1629
   35.3000  -80.1276
   35.4000  -80.0921
   35.5000  -80.0567
   35.6000  -80.0215
   35.7000  -79.9863
   35.8000  -79.9510
   35.9000  -79.9158
   36.0000  -79.8806
   36.1000  -79.8452
   36.2000  -79.8099
   36.3000  -79.7746
   36.4000  -79.7394
   36.5000  -79.7043
   36.6000  -79.6692
   36.7000  -79.6341
   36.8000  -79.5988
   36.9000  -79.5635
   37.0000  -79.5284
   37.1000  -79.4933
   37.2000  -79.4584
   37.3000  -79.4234
   37.4000  -79.3884
   37.5000  -79.3533
   37.6000  -79.3182
   37.7000  -79.2832
   37.8000  -79.2484
   37.9000  -79.2137
   38.0000  -79.1789
   38.1000  -79.1440
   38.2000  -79.1092
   38.3000  -79.0744
   38.4000  -79.0397
   38.5000  -79.0051
   38.6000  -78.9706
   38.7000  -78.9360
   38.8000  -78.9015
   38.9000  -78.8671
   39.0000  -78.8325
   39.1000  -78.7981
   39.2000  -78.7638
   39.3000  -78.7295
   39.4000  -78.6953
   39.5000  -78.6613
   39.6000  -78.6272
   39.7000  -78.5930
   39.8000  -78.5589
   39.9000  -78.5250
   40.0000  -78.4912
   40.1000  -78.4573
   40.2000  -78.4236
   40.3000  -78.3900
   40.4000  -78.3564
   40.5000  -78.3227
   40.6000  -78.2892
   40.7000  -78.2558
   40.8000  -78.2223
   40.9000  -78.1891
   41.0000  -78.1560
   41.1000  -78.1231
   41.2000  -78.0898
   41.3000  -78.0567
   41.4000  -78.0237
   41.5000  -77.9909
   41.6000  -77.9582
   41.7000  -77.9257
   41.8000  -77.8933
   41.9000  -77.8608
   42.0000  -77.8281
   42.1000  -77.7957
   42.2000  -77.7634
   42.3000  -77.7313
   42.4000  -77.6993
   42.5000  -77.6674
   42.6000  -77.6357
   42.7000  -77.6038
   42.8000  -77.5720
   42.9000  -77.5402
   43.0000  -77.5086
   43.1000  -77.4772
   43.2000  -77.4460
   43.3000  -77.4150
   43.4000  -77.3841
   43.5000  -77.3530
   43.6000  -77.3218
   43.7000  -77.2907
   43.8000  -77.2600
   43.9000  -77.2294
   44.0000  -77.1991
   44.1000  -77.1689
   44.2000  -77.1388
   44.3000  -77.1085
   44.4000  -77.0781
   44.5000  -77.0479
   44.6000  -77.0180
   44.7000  -76.9883
   44.8000  -76.9588
   44.9000  -76.9294
   45.0000  -76.9002
   45.1000  -76.8711
   45.2000  -76.8415
   45.3000  -76.8121
   45.4000  -76.7830
   45.5000  -76.7542
   45.6000  -76.7255
   45.7000  -76.6971
   45.8000  -76.6689
   45.9000  -76.6408
   46.0000  -76.6125
   46.1000  -76.5837
   46.2000  -76.5554
   46.3000  -76.5275
   46.4000  -76.4998
   46.5000  -76.4723
   46.6000  -76.4450
   46.7000  -76.4179
   46.8000  -76.3908
   46.9000  -76.3634
   47.0000  -76.3358
   47.1000  -76.3086
   47.2000  -76.2818
   47.3000  -76.2553
   47.4000  -76.2290
   47.5000  -76.2028
   47.6000  -76.1767
   47.7000  -76.1506
   47.8000  -76.1246
   47.9000  -76.0981
   48.0000  -76.0721
   48.1000  -76.0464
   48.2000  -76.0209
   48.3000  -75.9957
   48.4000  -75.9706
   48.5000  -75.9457
   48.6000  -75.9208
   48.7000  -75.8960
   48.8000  -75.8713
   48.9000  -75.8461
   49.0000  -75.8213
   49.1000  -75.7969
   49.2000  -75.7727
   49.3000  -75.7488
   49.4000  -75.7251
   49.5000  -75.7015
   49.6000  -75.6779
   49.7000  -75.6543
   49.8000  -75.6309
   49.9000  -75.6072