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Striatal Spiny Projection Neuron, inhibition enhances spatial specificity (Dorman et al 2018)
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Accession:
245411
We use a computational model of a striatal spiny projection neuron to investigate dendritic spine calcium dynamics in response to spatiotemporal patterns of synaptic inputs. We show that spine calcium elevation is stimulus-specific, with supralinear calcium elevation in cooperatively stimulated spines. Intermediate calcium elevation occurs in neighboring non-stimulated dendritic spines, predicting heterosynaptic effects. Inhibitory synaptic inputs enhance the difference between peak calcium in stimulated spines, and peak calcium in non-stimulated spines, thereby enhancing stimulus specificity.
Reference:
1 .
Dorman DB, Jedrzejewska-Szmek J, Blackwell KT (2018) Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model.
Elife
, Kennedy, Mary B, ed.
[
PubMed
]
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Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Basal ganglia;
Cell Type(s):
Neostriatum spiny neuron;
Channel(s):
Ca pump;
Kir;
I A;
I A, slow;
I CAN;
I K,Ca;
I Krp;
I Na,t;
I L high threshold;
I R;
I T low threshold;
IK Bkca;
IK Skca;
Na/Ca exchanger;
Gap Junctions:
Receptor(s):
AMPA;
NMDA;
GabaA;
Gene(s):
Cav3.2 CACNA1H;
Cav3.3 CACNA1I;
Cav1.2 CACNA1C;
Cav1.3 CACNA1D;
Cav2.2 CACNA1B;
Kv4.2 KCND2;
Kir2.1 KCNJ2;
Kv2.1 KCNB1;
Transmitter(s):
Gaba;
Glutamate;
Simulation Environment:
GENESIS;
Model Concept(s):
Calcium dynamics;
Detailed Neuronal Models;
Synaptic Integration;
Synaptic Plasticity;
Implementer(s):
Dorman, Daniel B ;
Search NeuronDB
for information about:
GabaA
;
AMPA
;
NMDA
;
I Na,t
;
I L high threshold
;
I T low threshold
;
I A
;
I K,Ca
;
I CAN
;
I A, slow
;
Na/Ca exchanger
;
I Krp
;
I R
;
Ca pump
;
Kir
;
IK Bkca
;
IK Skca
;
Gaba
;
Glutamate
;
Download the displayed file
/
modelDB_eLife2018
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COMMIT_EDITMSG
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description
*
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HEAD
*
Other models using HEAD:
A general model of hippocampal and dorsal striatal learning and decision making (Geerts et al 2020)
Adaptive dual control of deep brain stimulation in Parkinsons disease simulations (Grado et al 2018)
Current Dipole in Laminar Neocortex (Lee et al. 2013)
Dendritic Discrimination of Temporal Input Sequences (Branco et al. 2010)
Distributed computing tool for NEURON, NEURONPM (screensaver) (Calin-Jageman and Katz 2006)
Inverse stochastic resonance of cerebellar Purkinje cell (Buchin et al. 2016)
Olfactory Bulb mitral-granule network generates beta oscillations (Osinski & Kay 2016)
Optimal synaptic assignment for locomotory behavior in C. elegans (Rakowski & Karbowski 2017)
Optimal synaptic assignment for locomotory behavior in C. elegans (Rakowski & Karbowski 2017)
Optimal synaptic assignment for locomotory behavior in C. elegans (Rakowski & Karbowski 2017)
Rat LGN Thalamocortical Neuron (Connelly et al 2015, 2016)
Recurrent amplification of grid-cell activity (D'Albis and Kempter 2020)
Robust transmission in the inhibitory Purkinje Cell to Cerebellar Nuclei pathway (Abbasi et al 2017)
Subiculum network model with dynamic chloride/potassium homeostasis (Buchin et al 2016)
Theory and simulation of integrate-and-fire neurons driven by shot noise (Droste & Lindner 2017)
Theory and simulation of integrate-and-fire neurons driven by shot noise (Droste & Lindner 2017)
Theory and simulation of integrate-and-fire neurons driven by shot noise (Droste & Lindner 2017)
Theory and simulation of integrate-and-fire neurons driven by shot noise (Droste & Lindner 2017)
Theory and simulation of integrate-and-fire neurons driven by shot noise (Droste & Lindner 2017)
Vibration-sensitive Honeybee interneurons (Ai et al 2017)
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Unnamed repository; edit this file 'description' to name the repository.
