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Striatal Spiny Projection Neuron, inhibition enhances spatial specificity (Dorman et al 2018)
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Accession:
245411
We use a computational model of a striatal spiny projection neuron to investigate dendritic spine calcium dynamics in response to spatiotemporal patterns of synaptic inputs. We show that spine calcium elevation is stimulus-specific, with supralinear calcium elevation in cooperatively stimulated spines. Intermediate calcium elevation occurs in neighboring non-stimulated dendritic spines, predicting heterosynaptic effects. Inhibitory synaptic inputs enhance the difference between peak calcium in stimulated spines, and peak calcium in non-stimulated spines, thereby enhancing stimulus specificity.
Reference:
1 .
Dorman DB, Jedrzejewska-Szmek J, Blackwell KT (2018) Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model.
Elife
, Kennedy, Mary B, ed.
[
PubMed
]
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Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Basal ganglia;
Cell Type(s):
Neostriatum spiny neuron;
Channel(s):
Ca pump;
Kir;
I A;
I A, slow;
I CAN;
I K,Ca;
I Krp;
I Na,t;
I L high threshold;
I R;
I T low threshold;
IK Bkca;
IK Skca;
Na/Ca exchanger;
Gap Junctions:
Receptor(s):
AMPA;
NMDA;
GabaA;
Gene(s):
Cav3.2 CACNA1H;
Cav3.3 CACNA1I;
Cav1.2 CACNA1C;
Cav1.3 CACNA1D;
Cav2.2 CACNA1B;
Kv4.2 KCND2;
Kir2.1 KCNJ2;
Kv2.1 KCNB1;
Transmitter(s):
Gaba;
Glutamate;
Simulation Environment:
GENESIS;
Model Concept(s):
Calcium dynamics;
Detailed Neuronal Models;
Synaptic Integration;
Synaptic Plasticity;
Implementer(s):
Dorman, Daniel B ;
Search NeuronDB
for information about:
GabaA
;
AMPA
;
NMDA
;
I Na,t
;
I L high threshold
;
I T low threshold
;
I A
;
I K,Ca
;
I CAN
;
I A, slow
;
Na/Ca exchanger
;
I Krp
;
I R
;
Ca pump
;
Kir
;
IK Bkca
;
IK Skca
;
Gaba
;
Glutamate
;
/
modelDB_eLife2018
.git
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Theory and simulation of integrate-and-fire neurons driven by shot noise (Droste & Lindner 2017)
Theory and simulation of integrate-and-fire neurons driven by shot noise (Droste & Lindner 2017)
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Theory and simulation of integrate-and-fire neurons driven by shot noise (Droste & Lindner 2017)
Theory and simulation of integrate-and-fire neurons driven by shot noise (Droste & Lindner 2017)
Theory and simulation of integrate-and-fire neurons driven by shot noise (Droste & Lindner 2017)
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Optimal synaptic assignment for locomotory behavior in C. elegans (Rakowski & Karbowski 2017)
Optimal synaptic assignment for locomotory behavior in C. elegans (Rakowski & Karbowski 2017)
Rat LGN Thalamocortical Neuron (Connelly et al 2015, 2016)
Recurrent amplification of grid-cell activity (D'Albis and Kempter 2020)
Subiculum network model with dynamic chloride/potassium homeostasis (Buchin et al 2016)
Vibration-sensitive Honeybee interneurons (Ai et al 2017)
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