Striatal Spiny Projection Neuron, inhibition enhances spatial specificity (Dorman et al 2018)

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Accession:245411
We use a computational model of a striatal spiny projection neuron to investigate dendritic spine calcium dynamics in response to spatiotemporal patterns of synaptic inputs. We show that spine calcium elevation is stimulus-specific, with supralinear calcium elevation in cooperatively stimulated spines. Intermediate calcium elevation occurs in neighboring non-stimulated dendritic spines, predicting heterosynaptic effects. Inhibitory synaptic inputs enhance the difference between peak calcium in stimulated spines, and peak calcium in non-stimulated spines, thereby enhancing stimulus specificity.
Reference:
1 . Dorman DB, Jedrzejewska-Szmek J, Blackwell KT (2018) Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model. Elife, Kennedy, Mary B, ed. [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Basal ganglia;
Cell Type(s): Neostriatum spiny neuron;
Channel(s): Ca pump; Kir; I A; I A, slow; I CAN; I K,Ca; I Krp; I Na,t; I L high threshold; I R; I T low threshold; IK Bkca; IK Skca; Na/Ca exchanger;
Gap Junctions:
Receptor(s): AMPA; NMDA; GabaA;
Gene(s): Cav3.2 CACNA1H; Cav3.3 CACNA1I; Cav1.2 CACNA1C; Cav1.3 CACNA1D; Cav2.2 CACNA1B; Kv4.2 KCND2; Kir2.1 KCNJ2; Kv2.1 KCNB1;
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Calcium dynamics; Detailed Neuronal Models; Synaptic Integration; Synaptic Plasticity;
Implementer(s): Dorman, Daniel B ;
Search NeuronDB for information about:  GabaA; AMPA; NMDA; I Na,t; I L high threshold; I T low threshold; I A; I K,Ca; I CAN; I A, slow; Na/Ca exchanger; I Krp; I R; Ca pump; Kir; IK Bkca; IK Skca; Gaba; Glutamate;
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modelDB_eLife2018
.git
hooks
applypatch-msg.sample *
commit-msg.sample *
post-update.sample *
pre-applypatch.sample *
pre-commit.sample *
prepare-commit-msg.sample *
pre-push.sample *
pre-rebase.sample *
pre-receive.sample *
update.sample *
                            
#!/bin/sh

# An example hook script to verify what is about to be pushed.  Called by "git
# push" after it has checked the remote status, but before anything has been
# pushed.  If this script exits with a non-zero status nothing will be pushed.
#
# This hook is called with the following parameters:
#
# $1 -- Name of the remote to which the push is being done
# $2 -- URL to which the push is being done
#
# If pushing without using a named remote those arguments will be equal.
#
# Information about the commits which are being pushed is supplied as lines to
# the standard input in the form:
#
#   <local ref> <local sha1> <remote ref> <remote sha1>
#
# This sample shows how to prevent push of commits where the log message starts
# with "WIP" (work in progress).

remote="$1"
url="$2"

z40=0000000000000000000000000000000000000000

while read local_ref local_sha remote_ref remote_sha
do
	if [ "$local_sha" = $z40 ]
	then
		# Handle delete
		:
	else
		if [ "$remote_sha" = $z40 ]
		then
			# New branch, examine all commits
			range="$local_sha"
		else
			# Update to existing branch, examine new commits
			range="$remote_sha..$local_sha"
		fi

		# Check for WIP commit
		commit=`git rev-list -n 1 --grep '^WIP' "$range"`
		if [ -n "$commit" ]
		then
			echo >&2 "Found WIP commit in $local_ref, not pushing"
			exit 1
		fi
	fi
done

exit 0