Striatal Spiny Projection Neuron, inhibition enhances spatial specificity (Dorman et al 2018)

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Accession:245411
We use a computational model of a striatal spiny projection neuron to investigate dendritic spine calcium dynamics in response to spatiotemporal patterns of synaptic inputs. We show that spine calcium elevation is stimulus-specific, with supralinear calcium elevation in cooperatively stimulated spines. Intermediate calcium elevation occurs in neighboring non-stimulated dendritic spines, predicting heterosynaptic effects. Inhibitory synaptic inputs enhance the difference between peak calcium in stimulated spines, and peak calcium in non-stimulated spines, thereby enhancing stimulus specificity.
Reference:
1 . Dorman DB, Jedrzejewska-Szmek J, Blackwell KT (2018) Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model. Elife, Kennedy, Mary B, ed. [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Basal ganglia;
Cell Type(s): Neostriatum spiny neuron;
Channel(s): Ca pump; Kir; I A; I A, slow; I CAN; I K,Ca; I Krp; I Na,t; I L high threshold; I R; I T low threshold; IK Bkca; IK Skca; Na/Ca exchanger;
Gap Junctions:
Receptor(s): AMPA; NMDA; GabaA;
Gene(s): Cav3.2 CACNA1H; Cav3.3 CACNA1I; Cav1.2 CACNA1C; Cav1.3 CACNA1D; Cav2.2 CACNA1B; Kv4.2 KCND2; Kir2.1 KCNJ2; Kv2.1 KCNB1;
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Calcium dynamics; Detailed Neuronal Models; Synaptic Integration; Synaptic Plasticity;
Implementer(s): Dorman, Daniel B ;
Search NeuronDB for information about:  GabaA; AMPA; NMDA; I Na,t; I L high threshold; I T low threshold; I A; I K,Ca; I CAN; I A, slow; Na/Ca exchanger; I Krp; I R; Ca pump; Kir; IK Bkca; IK Skca; Gaba; Glutamate;
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modelDB_eLife2018
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hooks
applypatch-msg.sample *
commit-msg.sample *
post-update.sample *
pre-applypatch.sample *
pre-commit.sample *
prepare-commit-msg.sample *
pre-push.sample *
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#!/bin/sh
#
# An example hook script to prepare the commit log message.
# Called by "git commit" with the name of the file that has the
# commit message, followed by the description of the commit
# message's source.  The hook's purpose is to edit the commit
# message file.  If the hook fails with a non-zero status,
# the commit is aborted.
#
# To enable this hook, rename this file to "prepare-commit-msg".

# This hook includes three examples.  The first comments out the
# "Conflicts:" part of a merge commit.
#
# The second includes the output of "git diff --name-status -r"
# into the message, just before the "git status" output.  It is
# commented because it doesn't cope with --amend or with squashed
# commits.
#
# The third example adds a Signed-off-by line to the message, that can
# still be edited.  This is rarely a good idea.

case "$2,$3" in
  merge,)
    /usr/bin/perl -i.bak -ne 's/^/# /, s/^# #/#/ if /^Conflicts/ .. /#/; print' "$1" ;;

# ,|template,)
#   /usr/bin/perl -i.bak -pe '
#      print "\n" . `git diff --cached --name-status -r`
#	 if /^#/ && $first++ == 0' "$1" ;;

  *) ;;
esac

# SOB=$(git var GIT_AUTHOR_IDENT | sed -n 's/^\(.*>\).*$/Signed-off-by: \1/p')
# grep -qs "^$SOB" "$1" || echo "$SOB" >> "$1"