Striatal Spiny Projection Neuron, inhibition enhances spatial specificity (Dorman et al 2018)

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We use a computational model of a striatal spiny projection neuron to investigate dendritic spine calcium dynamics in response to spatiotemporal patterns of synaptic inputs. We show that spine calcium elevation is stimulus-specific, with supralinear calcium elevation in cooperatively stimulated spines. Intermediate calcium elevation occurs in neighboring non-stimulated dendritic spines, predicting heterosynaptic effects. Inhibitory synaptic inputs enhance the difference between peak calcium in stimulated spines, and peak calcium in non-stimulated spines, thereby enhancing stimulus specificity.
1 . Dorman DB, Jedrzejewska-Szmek J, Blackwell KT (2018) Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model. Elife, Kennedy, Mary B, ed. [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Basal ganglia;
Cell Type(s): Neostriatum spiny neuron;
Channel(s): Ca pump; Kir; I A; I A, slow; I CAN; I K,Ca; I Krp; I Na,t; I L high threshold; I R; I T low threshold; IK Bkca; IK Skca; Na/Ca exchanger;
Gap Junctions:
Receptor(s): AMPA; NMDA; GabaA;
Gene(s): Cav3.2 CACNA1H; Cav3.3 CACNA1I; Cav1.2 CACNA1C; Cav1.3 CACNA1D; Cav2.2 CACNA1B; Kv4.2 KCND2; Kir2.1 KCNJ2; Kv2.1 KCNB1;
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Calcium dynamics; Detailed Neuronal Models; Synaptic Integration; Synaptic Plasticity;
Implementer(s): Dorman, Daniel B ;
Search NeuronDB for information about:  GabaA; AMPA; NMDA; I Na,t; I L high threshold; I T low threshold; I A; I K,Ca; I CAN; I A, slow; Na/Ca exchanger; I Krp; I R; Ca pump; Kir; IK Bkca; IK Skca; Gaba; Glutamate;
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# An example hook script to block unannotated tags from entering.
# Called by "git receive-pack" with arguments: refname sha1-old sha1-new
# To enable this hook, rename this file to "update".
# Config
# ------
# hooks.allowunannotated
#   This boolean sets whether unannotated tags will be allowed into the
#   repository.  By default they won't be.
# hooks.allowdeletetag
#   This boolean sets whether deleting tags will be allowed in the
#   repository.  By default they won't be.
# hooks.allowmodifytag
#   This boolean sets whether a tag may be modified after creation. By default
#   it won't be.
# hooks.allowdeletebranch
#   This boolean sets whether deleting branches will be allowed in the
#   repository.  By default they won't be.
# hooks.denycreatebranch
#   This boolean sets whether remotely creating branches will be denied
#   in the repository.  By default this is allowed.

# --- Command line

# --- Safety check
if [ -z "$GIT_DIR" ]; then
	echo "Don't run this script from the command line." >&2
	echo " (if you want, you could supply GIT_DIR then run" >&2
	echo "  $0 <ref> <oldrev> <newrev>)" >&2
	exit 1

if [ -z "$refname" -o -z "$oldrev" -o -z "$newrev" ]; then
	echo "usage: $0 <ref> <oldrev> <newrev>" >&2
	exit 1

# --- Config
allowunannotated=$(git config --bool hooks.allowunannotated)
allowdeletebranch=$(git config --bool hooks.allowdeletebranch)
denycreatebranch=$(git config --bool hooks.denycreatebranch)
allowdeletetag=$(git config --bool hooks.allowdeletetag)
allowmodifytag=$(git config --bool hooks.allowmodifytag)

# check for no description
projectdesc=$(sed -e '1q' "$GIT_DIR/description")
case "$projectdesc" in
"Unnamed repository"* | "")
	echo "*** Project description file hasn't been set" >&2
	exit 1

# --- Check types
# if $newrev is 0000...0000, it's a commit to delete a ref.
if [ "$newrev" = "$zero" ]; then
	newrev_type=$(git cat-file -t $newrev)

case "$refname","$newrev_type" in
		# un-annotated tag
		if [ "$allowunannotated" != "true" ]; then
			echo "*** The un-annotated tag, $short_refname, is not allowed in this repository" >&2
			echo "*** Use 'git tag [ -a | -s ]' for tags you want to propagate." >&2
			exit 1
		# delete tag
		if [ "$allowdeletetag" != "true" ]; then
			echo "*** Deleting a tag is not allowed in this repository" >&2
			exit 1
		# annotated tag
		if [ "$allowmodifytag" != "true" ] && git rev-parse $refname > /dev/null 2>&1
			echo "*** Tag '$refname' already exists." >&2
			echo "*** Modifying a tag is not allowed in this repository." >&2
			exit 1
		# branch
		if [ "$oldrev" = "$zero" -a "$denycreatebranch" = "true" ]; then
			echo "*** Creating a branch is not allowed in this repository" >&2
			exit 1
		# delete branch
		if [ "$allowdeletebranch" != "true" ]; then
			echo "*** Deleting a branch is not allowed in this repository" >&2
			exit 1
		# tracking branch
		# delete tracking branch
		if [ "$allowdeletebranch" != "true" ]; then
			echo "*** Deleting a tracking branch is not allowed in this repository" >&2
			exit 1
		# Anything else (is there anything else?)
		echo "*** Update hook: unknown type of update to ref $refname of type $newrev_type" >&2
		exit 1

# --- Finished
exit 0