CA1 network model for place cell dynamics (Turi et al 2019)

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Accession:246546
Biophysical model of CA1 hippocampal region. The model simulates place cells/fields and explores the place cell dynamics as function of VIP+ interneurons.
Reference:
1 . Turi GF, Li W, Chavlis S, Pandi I, O’Hare J, Priestley JB, Grosmark AD, Liao Z, Ladow M, Zhang JF, Zemelman BV, Poirazi P, Losonczy A (2019) Vasoactive Intestinal Polypeptide-Expressing Interneurons in the Hippocampus Support Goal-Oriented Spatial Learning Neuron
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Hippocampus; Mouse;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell; Hippocampus CA1 basket cell; Hippocampus CA1 basket cell - CCK/VIP; Hippocampus CA1 bistratified cell; Hippocampus CA1 axo-axonic cell; Hippocampus CA1 stratum oriens lacunosum-moleculare interneuron ; Hippocampal CA1 CR/VIP cell;
Channel(s): I A; I h; I K,Ca; I Calcium; I Na, leak; I K,leak; I M;
Gap Junctions:
Receptor(s): GabaA; GabaB; NMDA; AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; Brian;
Model Concept(s): Place cell/field;
Implementer(s): Chavlis, Spyridon [schavlis at imbb.forth.gr]; Pandi, Ioanna ;
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; GabaA; GabaB; AMPA; NMDA; I A; I K,leak; I M; I h; I K,Ca; I Calcium; I Na, leak;
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Turi_et_al_2018
mechanisms
ANsyn.mod *
bgka.mod *
burststim2.mod *
cad.mod
cadyn.mod *
cadyn_new.mod *
cagk.mod *
cal.mod *
calH.mod *
cancr.mod *
car.mod *
cat.mod *
ccanl.mod *
gskch.mod *
h.mod *
hha_old.mod *
hha2.mod *
hNa.mod *
IA.mod *
iccr.mod *
ichan2.mod *
ichan2aa.mod *
ichan2bc.mod *
ichan2bs.mod *
ichan2vip.mod *
Ih.mod *
Ihvip.mod *
ikscr.mod *
kad.mod *
kadistcr.mod *
kap.mod *
Kaxon.mod *
kca.mod *
Kdend.mod *
kdrcr.mod *
km.mod *
Ksoma.mod *
LcaMig.mod *
my_exp2syn.mod *
Naaxon.mod *
Nadend.mod *
nafcr.mod *
nap.mod *
Nasoma.mod *
nca.mod *
nmda.mod *
regn_stim.mod *
somacar.mod *
STDPE2Syn.mod *
vecstim.mod *
                            
TITLE K-A channel from Klee Ficker and Heinemann
: modified to account for Dax A Current ----------
: M.Migliore Jun 1997
: modified by Poirazi on 10/2/00 according to Hoffman_etal97 
: to account for I_A distal (>100microns)
: (n) activation, (l) inactivation


UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
}

INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}

PARAMETER {
        dt (ms)
	v (mV)
        ek (mV)              : must be explicitely def. in hoc
	gkabar=0.018 (mho/cm2)
        vhalfn= -1   (mV)
        vhalfl=-56   (mV)
}

NEURON {
	SUFFIX kad
	USEION k READ ek WRITE ik
        RANGE gkabar,gka
        GLOBAL ninf,linf,taul,taun
}

STATE {
	n
        l
}

ASSIGNED {
	ik (mA/cm2)
        ninf
        linf
        taul
        taun
        gka
}

INITIAL {
	rates(v)
	n=ninf
	l=linf
	gka = gkabar*n^4*l
	ik = gka*(v-ek)
}

BREAKPOINT {
	SOLVE states
	gka = gkabar*n^4*l
	ik = gka*(v-ek)
}

FUNCTION alpn(v(mV)) {
  alpn = -0.01*(v+34.4)/(exp((v+34.4)/-21)-1)
}


FUNCTION betn(v(mV)) {
  betn = 0.01*(v+34.4)/(exp((v+34.4)/21)-1)
}

FUNCTION alpl(v(mV)) {
  alpl = -0.01*(v+58)/(exp((v+58)/8.2)-1)
}

FUNCTION betl(v(mV)) {
  betl = 0.01*(v+58)/(exp((v+58)/-8.2)-1)
}

LOCAL facn,facl
PROCEDURE states() {     : exact when v held constant; integrates over dt step
        rates(v)
        n = n + facn*(ninf - n)
        l = l + facl*(linf - l)
        VERBATIM
        return 0;
        ENDVERBATIM
}

PROCEDURE rates(v (mV)) { :callable from hoc
        LOCAL a,b
        a = alpn(v)
        b = betn(v)
        ninf = a/(a + b)
        taun = 0.2
        facn = (1 - exp(-dt/taun))
        a = alpl(v)
        b = betl(v)
        linf = a/(a + b)
        
        if (v > -20) {
	   taul = 5 + 2.6*(v+20)/10
        } else {
	   taul = 5
        }
        facl = (1 - exp(-dt/taul))
}