Olfactory Mitral Cell (Davison et al 2000)

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Accession:2487
A four-compartment model of a mammalian olfactory bulb mitral cell, reduced from the complex 286-compartment model described by Bhalla and Bower (1993). The compartments are soma/axon, secondary dendrites, primary dendrite shaft and primary dendrite tuft. The reduced model runs 75 or more times faster than the full model, making its use in large, realistic network models of the olfactory bulb practical.
Reference:
1 . Davison AP, Feng J, Brown D (2000) A reduced compartmental model of the mitral cell for use in network models of the olfactory bulb. Brain Res Bull 51:393-9 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Olfactory bulb main mitral GLU cell;
Channel(s): I Na,t; I L high threshold; I A; I K; I K,leak; I K,Ca; I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Parameter Fitting; Simplified Models; Olfaction;
Implementer(s): Davison, Andrew [Andrew.Davison at iaf.cnrs-gif.fr];
Search NeuronDB for information about:  Olfactory bulb main mitral GLU cell; I Na,t; I L high threshold; I A; I K; I K,leak; I K,Ca; I Sodium; I Calcium; I Potassium;
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mit4
README.html
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kfasttab.mod
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abstract.hoc
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mit2_gi_0p2.dat
mit2_gi_1p6.dat
mit2_si_0p2.dat
mit2_si_1p6.dat
mit4.hoc
mit4.ses
mit4_init.hoc
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tabchannels.hoc
                            
proc show_abstract() {

xpanel("Abstract")
xlabel("Davison A.P., Feng J. & Brown D. (2000)")
xlabel("A reduced compartmental model of the mitral cell")
xlabel("for use in network models of the olfactory bulb.")
xlabel("Brain Research Bulletin 51(5): 393-399.")
xlabel("")
xlabel("We have developed two-, three- and four-compartment")
xlabel("models of a mammalian olfactory bulb mitral cell as")
xlabel("a reduction of a complex 286- compartment model.")
xlabel("A minimum of three compartments, representing soma,")
xlabel("secondary (basal) dendrites and the glomerular tuft")
xlabel("of the primary dendrite, is required to adequately")
xlabel("reproduce the behaviour of the full model over a")
xlabel("broad range of firing rates. Adding a fourth")
xlabel("compartment to represent the shaft of the primary")
xlabel("dendrite gives a substantial improvement. The")
xlabel("reduced models exhibit behaviours in common with the")
xlabel("full model which were not used in fitting the model")
xlabel("parameters. The reduced models run 75 or more times")
xlabel("faster than the full model, making their use in large,")
xlabel("realistic network models of the olfactory bulb practical.")
xpanel(125,670)

}