COMMENT
kca.mod
Calciumdependent potassium channel
Based on
Pennefather (1990)  sympathetic ganglion cells
taken from
Reuveni et al (1993)  neocortical cells
Author: Zach Mainen, Salk Institute, 1995, zach@salk.edu
26 Ago 2002 Modification of original channel to allow
variable time step and to correct an initialization error.
Done by Michael Hines(michael.hines@yale.e) and
Ruggero Scorcioni(rscorcio@gmu.edu) at EU Advance Course
in Computational Neuroscience. Obidos, Portugal
20110202 made threadsafe by Ted Carnevale
20120105 SOLVE switched to derivimplicit from euler  TMM
20120106 SOLVE switched back to cnexp because ode linear in n TMM
Special comment:
This mechanism was designed to be run at a single operating
temperature37 deg Cwhich can be specified by the hoc
assignment statement
celsius = 37
This mechanism is not intended to be used at other temperatures,
or to investigate the effects of temperature changes.
Zach Mainen created this particular model by adapting conductances
from lower temperature to run at higher temperature, and found it
necessary to reduce the temperature sensitivity of spike amplitude
and time course. He accomplished this by increasing the net ionic
conductance through the heuristic of changing the standard HH
formula
g = gbar*product_of_gating_variables
to
g = tadj*gbar*product_of_gating_variables
where
tadj = q10^((celsius  temp)/10)
temp is the "reference temperature" (at which the gating variable
time constants were originally determined)
celsius is the "operating temperature"
Users should note that this is equivalent to changing the channel
density from gbar at the "reference temperature" temp (the
temperature at which the at which the gating variable time
constants were originally determined) to tadj*gbar at the
"operating temperature" celsius.
ENDCOMMENT
INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}
NEURON {
THREADSAFE
SUFFIX kca
USEION k READ ek WRITE ik
USEION ca READ cai
RANGE n, gk, gbar
RANGE ninf, ntau
GLOBAL Ra, Rb, caix
GLOBAL q10, temp, tadj, vmin, vmax
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
(pS) = (picosiemens)
(um) = (micron)
}
PARAMETER {
gbar = 10 (pS/um2) : 0.03 mho/cm2
v (mV)
cai (mM)
caix = 1
Ra = 0.01 (/ms) : max act rate
Rb = 0.02 (/ms) : max deact rate
dt (ms)
celsius (degC)
temp = 23 (degC) : original temp
q10 = 2.3 : temperature sensitivity
vmin = 120 (mV)
vmax = 100 (mV)
}
ASSIGNED {
a (/ms)
b (/ms)
ik (mA/cm2)
gk (pS/um2)
ek (mV)
ninf
ntau (ms)
tadj
}
STATE { n }
INITIAL {
rates(cai)
n = ninf
}
BREAKPOINT {
SOLVE states METHOD cnexp
gk = tadj*gbar*n
ik = (1e4) * gk * (v  ek)
}
LOCAL nexp
DERIVATIVE states { :Computes state variable n
rates(cai) : at the current v and dt.
n' = (ninfn)/ntau
}
PROCEDURE rates(cai(mM)) {
a = Ra * cai^caix
b = Rb
tadj = q10^((celsius  temp)/10)
ntau = 1/tadj/(a+b)
ninf = a/(a+b)
: tinc = dt * tadj
: nexp = 1  exp(tinc/ntau)
}
