Single compartment: nonlinear a5-GABAAR controls synaptic NMDAR activation (Schulz et al 2018)

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Accession:258946
This study shows that IPSCs mediated by a5-subunit containing GABAA receptors are strongly outward-rectifying generating 4-fold larger conductances above -50?mV than at rest. This model shows that synaptic activation of these receptors can very effectively control voltage-dependent NMDA-receptor activation. The files contain the NEURON code for Fig.6 and Fig.7. The model is a single dendritic compartment with one glutamatergic and GABAergic synapse. Physiological properties of GABA synapses were modeled as determined by optogenetic activation of inputs during voltage-clamp recordings in Schulz et al. 2018.
Reference:
1 . Schulz JM, Knoflach F, Hernandez MC, Bischofberger J (2018) Dendrite-targeting interneurons control synaptic NMDA-receptor activation via nonlinear a5-GABAA receptors. Nat Commun 9:3576 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type:
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s): AMPA; GabaA; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s):
Implementer(s): Schulz, Jan M [j.schulz at unibas.ch];
Search NeuronDB for information about:  GabaA; AMPA; NMDA; Gaba; Glutamate;