Biochemically detailed model of LTP and LTD in a cortical spine (Maki-Marttunen et al 2020)

 Download zip file   Auto-launch 
Help downloading and running models
"Signalling pathways leading to post-synaptic plasticity have been examined in many types of experimental studies, but a unified picture on how multiple biochemical pathways collectively shape neocortical plasticity is missing. We built a biochemically detailed model of post-synaptic plasticity describing CaMKII, PKA, and PKC pathways and their contribution to synaptic potentiation or depression. We developed a statistical AMPA-receptor-tetramer model, which permits the estimation of the AMPA-receptor-mediated maximal synaptic conductance based on numbers of GluR1s and GluR2s predicted by the biochemical signalling model. We show that our model reproduces neuromodulator-gated spike-timing-dependent plasticity as observed in the visual cortex and can be fit to data from many cortical areas, uncovering the biochemical contributions of the pathways pinpointed by the underlying experimental studies. Our model explains the dependence of different forms of plasticity on the availability of different proteins and can be used for the study of mental disorder-associated impairments of cortical plasticity."
1 . Mäki-Marttunen T, Iannella N, Edwards AG, Einevoll GT, Blackwell KT (2020) A unified computational model for cortical post-synaptic plasticity. Elife [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex spiking regular (RS) neuron;
Channel(s): I Calcium;
Gap Junctions:
Transmitter(s): Glutamate; Norephinephrine; Acetylcholine;
Simulation Environment: NEURON; NeuroRD;
Model Concept(s): Long-term Synaptic Plasticity;
Implementer(s): Maki-Marttunen, Tuomo [tuomomm at];
Search NeuronDB for information about:  I Calcium; Acetylcholine; Norephinephrine; Glutamate;
biophysics.hoc *
cellinfo.json *
constants.hoc *
creategui.hoc *
createsimulation.hoc *
current_amps.dat *
init.hoc *
morphology.hoc *
mosinit.hoc *
ringplot.hoc * * * * * *
The CC-BY-NC-SA license applies, as indicated by headers in the
respective source files.

The detailed text is available here

or in this tarball in the seperate file LICENSE_CC-BY-CA-SA-4.0

The HOC code, Python code, synapse MOD code and cell morphology are licensed with the above mentioned CC-BY-NC-SA license.

For models for which the original source is available on ModelDB, any
specific licenses on mentioned on ModelDB, or the generic License of ModelDB 

1) Ih model
Author: Stefan Hallermann
Original URL:\HallermannEtAl2012\h.mod

2) StochKv model
Authors: Zach Mainen Adaptations: Kamran Diba, Mickey London, Peter N. Steinmetz, Werner Van Geit
Original URL:\Sbpap_code\mod\skm.mod

3) D-type K current model
Authors: Yuguo Yu
Original URL:\YuEtAlPNAS2007\kd.mod

4) Internal calcium concentration model
Author: Alain Destexhe
Original URL:\NTW_NEW\capump.mod

5) Ca_LVAst, Im, K_Tst, NaTa_t, SK_E2, Ca_HVA, Ih, K_Pst, Nap_Et2, NaTs2_t, SKv3_1            
Author: Etay Hay, Shaul Druckmann, Srikanth Ramaswamy, James King, Werner Van Geit
Original URL:\L5bPCmodelsEH\mod\