Mice Somatosensory L2/3 Pyramidal cells (Iascone et al 2020)

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Accession:261460
Mice L2/3 pyramidal cells with full excitatory and inhibitory synaptic maps (Models used in Whole-neuron synaptic mapping reveals local balance between excitatory and inhibitory synapse organization - Iascone et at 2020)
Reference:
1 . Iascone DM, Li Y, Sümbül U, Doron M, Chen H, Andreu V, Goudy F, Blockus H, Abbott LF, Segev I, Peng H, Polleux F (2020) Whole-Neuron Synaptic Mapping Reveals Spatially Precise Excitatory/Inhibitory Balance Limiting Dendritic and Somatic Spiking Neuron
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Neocortex;
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Synaptic-input statistic;
Implementer(s): Doron, Michael [michael.doron at mail.huji.ac.il];
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IasconeEtAl2020
mod_files
Ca_HVA.mod *
Ca_LVAst.mod *
CaDynamics_E2.mod *
Ih.mod *
Im.mod *
K_Pst.mod *
K_Tst.mod *
Nap_Et2.mod *
NaTa_t.mod *
NaTs2_t.mod *
ProbAMPA.mod
ProbAMPANMDA2_ratio.mod *
ProbUDFsyn2_lark.mod *
SK_E2.mod *
SKv3_1.mod *
vecevent.mod *
                            
:Comment :
:Reference : :		Kole,Hallermann,and Stuart, J. Neurosci. 2006

NEURON	{
	SUFFIX Ih
	NONSPECIFIC_CURRENT ihcn
	RANGE gIhbar, gIh, ihcn 
}

UNITS	{
	(S) = (siemens)
	(mV) = (millivolt)
	(mA) = (milliamp)
}

PARAMETER	{
	gIhbar = 0.00001 (S/cm2) 
	ehcn =  -45.0 (mV)
}

ASSIGNED	{
	v	(mV)
	ihcn	(mA/cm2)
	gIh	(S/cm2)
	mInf
	mTau
	mAlpha
	mBeta
}

STATE	{ 
	m
}

BREAKPOINT	{
	SOLVE states METHOD cnexp
	gIh = gIhbar*m
	ihcn = gIh*(v-ehcn)
}

DERIVATIVE states	{
	rates()
	m' = (mInf-m)/mTau
}

INITIAL{
	rates()
	m = mInf
}

PROCEDURE rates(){
	UNITSOFF
        if(v == -154.9){
            v = v + 0.0001
        }
		mAlpha =  0.001*6.43*(v+154.9)/(exp((v+154.9)/11.9)-1)
		mBeta  =  0.001*193*exp(v/33.1)
		mInf = mAlpha/(mAlpha + mBeta)
		mTau = 1/(mAlpha + mBeta)
	UNITSON
}