"During wakefulness, neocortical neurons are subjected to an intense
synaptic bombardment. To assess the consequences of this background
activity for the integrative properties of pyramidal neurons, we
constrained biophysical models with in vivo intracellular data
obtained in anesthetized cats during periods of intense network
activity similar to that observed in the waking state. In pyramidal
cells of the parietal cortex (area 5–7), synaptic activity was
responsible for an approximately fivefold decrease in input resistance
(Rin), a more depolarized membrane potential (Vm), and a marked
increase in the amplitude of Vm fluctuations, as determined by
comparing the same cells before and after microperfusion of
tetrodotoxin (TTX).
..."
Reference:
1 .
Destexhe A, Paré D (1999) Impact of network activity on the integrative properties of neocortical pyramidal neurons in vivo. J Neurophysiol 81:1531-47 [PubMed]
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