Survey of electrically evoked responses in the retina (Tsai et al 2017)

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Accession:262389
"Cones and horizontal cells are interconnected to adjacent cones and horizontal cells, respectively, with gap junctions. In particular, the horizontal cell gap junctional conductance is modulated by exogenous factors. What roles does this conductance play in the electrically evoked responses of horizontal cells? To address this question, we constructed a computational model consisting of the cone and horizontal cell layer..."
Reference:
1 . Tsai D, Morley JW, Suaning GJ, Lovell NH (2017) Survey of electrically evoked responses in the retina - stimulus preferences and oscillation among neurons. Sci Rep 7:13802 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Extracellular;
Brain Region(s)/Organism: Retina;
Cell Type(s): Retina photoreceptor cone GLU cell; Retina horizontal cell;
Channel(s):
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Oscillations;
Implementer(s): Tsai, David [d.tsai at unsw.edu.au];
Search NeuronDB for information about:  Retina photoreceptor cone GLU cell;
TITLE Photoreceptor input current for horizontal cells
: Simulated photoreceptor EPSC for horizontal cells


NEURON {
    POINT_PROCESS PRInput
    RANGE delSteady, durSteady, ampSteady, i
    ELECTRODE_CURRENT i
}

UNITS {
    (nA) = (nanoamp)
}

PARAMETER {
    delSteady (ms)
    durSteady (ms)  < 0, 1e9 >
    ampSteady (nA)
}

ASSIGNED {
    i (nA)
}

BREAKPOINT {
    : purturbation at the following time points
    at_time(delSteady)
    at_time(delSteady + durSteady)

    if (t > delSteady && t < delSteady + durSteady) {
        i = ampSteady
    } else {
        i = 0
    }
}