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Cerebellar granule cell (Masoli et al 2020)
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Model Information
Model File
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Accession:
265584
"The cerebellar granule cells (GrCs) are classically described as a homogeneous neuronal population discharging regularly without adaptation. We show that GrCs in fact generate diverse response patterns to current injection and synaptic activation, ranging from adaptation to acceleration of firing. Adaptation was predicted by parameter optimization in detailed computational models based on available knowledge on GrC ionic channels. The models also predicted that acceleration required additional mechanisms. We found that yet unrecognized TRPM4 currents specifically accounted for firing acceleration and that adapting GrCs outperformed accelerating GrCs in transmitting high-frequency mossy fiber (MF) bursts over a background discharge. This implied that GrC subtypes identified by their electroresponsiveness corresponded to specific neurotransmitter release probability values. Simulations showed that fine-tuning of pre- and post-synaptic parameters generated effective MF-GrC transmission channels, which could enrich the processing of input spike patterns and enhance spatio-temporal recoding at the cerebellar input stage."
Reference:
1 .
Masoli S, Tognolina M, Laforenza U, Moccia F, D'Angelo E (2020) Parameter tuning differentiates granule cell subtypes enriching transmission properties at the cerebellum input stage.
Commun Biol
3
:222
[
PubMed
]
Citations
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Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cerebellum;
Cell Type(s):
Cerebellum interneuron granule GLU cell;
Channel(s):
Ca pump;
I Na, leak;
I Calcium;
Gap Junctions:
Receptor(s):
AMPA;
NMDA;
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Python;
Model Concept(s):
Action Potentials;
Calcium dynamics;
Synaptic Integration;
Implementer(s):
Masoli, Stefano [stefano.masoli at unipv.it];
Search NeuronDB
for information about:
Cerebellum interneuron granule GLU cell
;
AMPA
;
NMDA
;
I Calcium
;
I Na, leak
;
Ca pump
;
/
Granule_cell_2020
03_GrC_2020_adapting
mod_files
cdp5_CR.mod
*
Other models using cdp5_CR.mod:
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
GRANULE_Ampa_det_vi.mod
*
Other models using GRANULE_Ampa_det_vi.mod:
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
GRANULE_Nmda_det_vi.mod
*
Other models using GRANULE_Nmda_det_vi.mod:
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
GRC_CA.mod
*
Other models using GRC_CA.mod:
Cerebellar Golgi cells, dendritic processing, and synaptic plasticity (Masoli et al 2020)
Cerebellar Golgi cells, dendritic processing, and synaptic plasticity (Masoli et al 2020)
Cerebellar cortex oscil. robustness from Golgi cell gap jncs (Simoes de Souza and De Schutter 2011)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellum granule cell FHF (Dover et al. 2016)
Multicompartmental cerebellar granule cell model (Diwakar et al. 2009)
Reconstructing cerebellar granule layer evoked LFP using convolution (ReConv) (Diwakar et al. 2011)
GRC_KM.mod
*
Other models using GRC_KM.mod:
Cerebellar Golgi cells, dendritic processing, and synaptic plasticity (Masoli et al 2020)
Cerebellar Golgi cells, dendritic processing, and synaptic plasticity (Masoli et al 2020)
Cerebellar cortex oscil. robustness from Golgi cell gap jncs (Simoes de Souza and De Schutter 2011)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Multicompartmental cerebellar granule cell model (Diwakar et al. 2009)
Reconstructing cerebellar granule layer evoked LFP using convolution (ReConv) (Diwakar et al. 2011)
GRC_NA.mod
*
Other models using GRC_NA.mod:
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
GRC_NA_FHF.mod
*
Other models using GRC_NA_FHF.mod:
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Kca11.mod
*
Other models using Kca11.mod:
A detailed Purkinje cell model (Masoli et al 2015)
Cerebellar Golgi cells, dendritic processing, and synaptic plasticity (Masoli et al 2020)
Cerebellar Golgi cells, dendritic processing, and synaptic plasticity (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Purkinje cell: Synaptic activation predicts voltage control of burst-pause (Masoli & D'Angelo 2017)
Kca22.mod
*
Other models using Kca22.mod:
A detailed Purkinje cell model (Masoli et al 2015)
Cerebellar Golgi cells, dendritic processing, and synaptic plasticity (Masoli et al 2020)
Cerebellar Golgi cells, dendritic processing, and synaptic plasticity (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Purkinje cell: Synaptic activation predicts voltage control of burst-pause (Masoli & D'Angelo 2017)
Kir23.mod
*
Other models using Kir23.mod:
A detailed Purkinje cell model (Masoli et al 2015)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Purkinje cell: Synaptic activation predicts voltage control of burst-pause (Masoli & D'Angelo 2017)
Kv11.mod
*
Other models using Kv11.mod:
A detailed Purkinje cell model (Masoli et al 2015)
Cerebellar Golgi cells, dendritic processing, and synaptic plasticity (Masoli et al 2020)
Cerebellar Golgi cells, dendritic processing, and synaptic plasticity (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Purkinje cell: Synaptic activation predicts voltage control of burst-pause (Masoli & D'Angelo 2017)
Kv15.mod
*
Other models using Kv15.mod:
A detailed Purkinje cell model (Masoli et al 2015)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Purkinje cell: Synaptic activation predicts voltage control of burst-pause (Masoli & D'Angelo 2017)
Kv22.mod
*
Other models using Kv22.mod:
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Kv34.mod
*
Other models using Kv34.mod:
A detailed Purkinje cell model (Masoli et al 2015)
Cerebellar Golgi cells, dendritic processing, and synaptic plasticity (Masoli et al 2020)
Cerebellar Golgi cells, dendritic processing, and synaptic plasticity (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Purkinje cell: Synaptic activation predicts voltage control of burst-pause (Masoli & D'Angelo 2017)
Kv43.mod
*
Other models using Kv43.mod:
A detailed Purkinje cell model (Masoli et al 2015)
Cerebellar Golgi cells, dendritic processing, and synaptic plasticity (Masoli et al 2020)
Cerebellar Golgi cells, dendritic processing, and synaptic plasticity (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Purkinje cell: Synaptic activation predicts voltage control of burst-pause (Masoli & D'Angelo 2017)
Leak.mod
*
Other models using Leak.mod:
A detailed Purkinje cell model (Masoli et al 2015)
Cerebellar Golgi cells, dendritic processing, and synaptic plasticity (Masoli et al 2020)
Cerebellar Golgi cells, dendritic processing, and synaptic plasticity (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Purkinje cell: Synaptic activation predicts voltage control of burst-pause (Masoli & D'Angelo 2017)
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