Molecular layer interneurons in cerebellum encode valence in associative learning (Ma et al 2020)

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Accession:266578
We used two-photon microscopy to study the role of ensembles of cerebellar molecular layer interneurons (MLIs) in a go-no go task where mice obtain a sugar water reward. In order to begin understanding the circuit basis of our findings in changes in lick behavior with chemogenetics in the go-no go associative learning olfactory discrimination task we generated a simple computational model of MLI interaction with PCs.
Reference:
1 . Ma M, Futia GL, De Souza FM, Ozbay BN, Llano I, Gibson EA, Restrepo D (2020) Molecular layer interneurons in the cerebellum encode for valence in associative learning Nature Communications, accepted
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Cerebellum; Mouse;
Cell Type(s): Cerebellum Purkinje GABA cell; Cerebellum interneuron stellate GABA cell;
Channel(s):
Gap Junctions:
Receptor(s): AMPA; GabaA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Action Potentials; Detailed Neuronal Models;
Implementer(s): Simoes-de-Souza, Fabio [fabio.souza at ufabc.edu.br];
Search NeuronDB for information about:  Cerebellum Purkinje GABA cell; Cerebellum interneuron stellate GABA cell; GabaA; AMPA; Gaba; Glutamate;
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MaEtAl2020
README.html
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TITLE PUMP
: FORREST MD (2014) Two Compartment Model of the Cerebellar Purkinje Neuron
 

UNITS {
       (molar) = (1/liter)
        (pA) = (picoamp)
	(mV) =	(millivolt)
        (uS) = (micromho)
	(mA) =	(milliamp)
	(mM) =	(millimolar)
}


INDEPENDENT {v FROM -100 TO 50 WITH 50 (mV)}

NEURON {
	SUFFIX pump
:	USEION Na WRITE iNa VALENCE 1
:        USEION na READ nai
        USEION na READ nai  WRITE ina
	USEION k  WRITE ik
	RANGE  inapump,ipumpmax,n,km,kk,k,decline,initialdensity,lex,red
 
}


PARAMETER {
        dt (ms)
        nai   (mM)
:        ipumpmax  = 0.04   (mA/cm2)
        km = 10.0        (mM)
        n=1.5
        kk =  10.0        (mM)
        k = 1.5

        nainit = 4  (mM)
        celsius = 35  (degC)
        T = 1
 decline = 0
initialdensity = 1    (mA/cm2)
 lex = 100000 (ms)       :   if 100 then we get fast declining pump. if like 100,000. then we dont really get decline        
   red = 3000 (ms)     
 
}

ASSIGNED { 
           ina		(mA/cm2)
           iNa		(mA/cm2)
           ik		(mA/cm2)
        inapump (mA/cm2)
          ipumpmax (mA/cm2)
        inapumping (mA/cm2)
         xm
          t_wait (ms)
}


INITIAL{
       ipumpmax = initialdensity
t_wait = 0
}


BREAKPOINT {LOCAL fnk
        inapump = ipumpmax


if (decline == 1)
{

if ( t > red) {   
if (t_wait < lex)
{t_wait = t_wait + dt }
else {
ipumpmax = ipumpmax - 0.001
t_wait = 0                    : this resets the counter.
}
}
if (ipumpmax < 0) {ipumpmax = 0}

}

: fnk = (v + 70)/(v+70.1)
: fnk = (v + 65)/(v+65.1)
: fnk = 1
: fnk = (v + 70)/(v + 80)
fnk = (v + 75)/(v + 80)

 inapump = ((ipumpmax*fnk)/(1+exp((km-nai)/n)))

	ina = 3.0*inapump
	ik = -2.0*inapump
}



COMMENT
INITIAL{
       nai = nainit}
ENDCOMMENT