Library of biophysically detailed striatal projection neurons (Lindroos and Hellgren Kotaleski 2020)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:266775
Library of compartmentalized models used to investigate dendritic integration in striatal projection neurons under neuromodulation.
Reference:
1 . Lindroos R, Hellgren Kotaleski J (2020) Predicting complex spikes in striatal projection neurons of the direct pathway following neuromodulation by acetylcholine and dopamine. Eur J Neurosci [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Synapse;
Brain Region(s)/Organism: Striatum; Hippocampus; Basal ganglia;
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; Striatal projection neuron;
Channel(s): I M; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s): Acetylcholine; Dopamine;
Simulation Environment: NEURON; Python;
Model Concept(s): Active Dendrites; Detailed Neuronal Models; Neuromodulation; Synaptic Plasticity; Activity Patterns; Soma-dendrite cross-talk;
Implementer(s): Lindroos, Robert [robert.lindroos at ki.se]; Filipovic, Marko;
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; I M; I Potassium; Acetylcholine; Dopamine;
TITLE T-type calcium current (Cav3.2)

UNITS {
    (mV) = (millivolt)
    (mA) = (milliamp)
    (S) = (siemens)
    (molar) = (1/liter)
    (mM) = (millimolar)
    FARADAY = (faraday) (coulomb)
    R = (k-mole) (joule/degC)
}

NEURON {
    SUFFIX cat32_ms
    USEION cal READ cali, calo WRITE ical VALENCE 2
    RANGE pbar, ical
}

PARAMETER {
    pbar = 0.0 (cm/s)
    :q = 1	: room temperature 21 C
    q = 3	: body temperature 35 C
} 

ASSIGNED { 
    v (mV)
    ical (mA/cm2)
    ecal (mV)
    celsius (degC)
    cali (mM)
    calo (mM)
    minf
    mtau (ms)
    hinf
    htau (ms)
}

STATE { m h }

BREAKPOINT {
    SOLVE states METHOD cnexp
    ical = pbar*m*m*m*h*ghk(v, cali, calo)
}

INITIAL {
    rates()
    m = minf
    h = hinf
}

DERIVATIVE states { 
    rates()
    m' = (minf-m)/mtau*q
    h' = (hinf-h)/htau*q
}

PROCEDURE rates() {
    UNITSOFF
    minf = 1/(1+exp((v-(-54))/(-7.8)))
    mtau = (2.1+23/(1+exp((v-(-61))/6)))*3
    hinf = 1/(1+exp((v-(-64.2))/8.8))
    htau = 30+280/(1+exp((v-(-52))/7))
    UNITSON
}

FUNCTION ghk(v (mV), ci (mM), co (mM)) (.001 coul/cm3) {
    LOCAL z, eci, eco
    z = (1e-3)*2*FARADAY*v/(R*(celsius+273.15))
    if(z == 0) {
        z = z+1e-6
    }
    eco = co*(z)/(exp(z)-1)
    eci = ci*(-z)/(exp(-z)-1)
    ghk = (1e-3)*2*FARADAY*(eci-eco)
}

COMMENT

Rat Cav3.2 channels were isolated and transfection of human embryonic
kidney cells was performed [1].  Electrophysiological recordings were
done in 21 C.

NEURON model by Alexander Kozlov <akozlov@kth.se>. Kinetics of m3h
type was used [2-4]. Activation time constant was scaled up accordingly.

[1] Iftinca M, McKay BE, Snutch TP, McRory JE, Turner RW, Zamponi
GW (2006) Temperature dependence of T-type calcium channel
gating. Neuroscience 142(4):1031-42.

[2] Crunelli V, Toth TI, Cope DW, Blethyn K, Hughes SW (2005) The
'window' T-type calcium current in brain dynamics of different behavioural
states. J Physiol 562(Pt 1):121-9.

[3] Wolf JA, Moyer JT, Lazarewicz MT, Contreras D, Benoit-Marand M,
O'Donnell P, Finkel LH (2005) NMDA/AMPA ratio impacts state transitions
and entrainment to oscillations in a computational model of the nucleus
accumbens medium spiny projection neuron. J Neurosci 25(40):9080-95.

[4] Evans RC, Maniar YM, Blackwell KT (2013) Dynamic modulation of
spike timing-dependent calcium influx during corticostriatal upstates. J
Neurophysiol 110(7):1631-45.

ENDCOMMENT